Gene: HLA-DQA2;
Trait | Type | #Publications | #Studies | #Associations | Correlations | CpG Island |
---|---|---|---|---|---|---|
adrenocortical carcinoma | cancer | 3 | 3 | 1369 | Hyper: 35%; Hypo: 60%; NR: 5% | cpg: 18%; shore: 17%; shelf: 12%; other: 53% |
B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1 | cancer | 2 | 2 | 4791 | Hyper: 32%; Hypo: 68%; NR: 0% | cpg: 21%; shore: 23%; shelf: 13%; other: 42% |
B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) | cancer | 1 | 1 | 21099 | Hyper: 85%; Hypo: 15%; NR: 0% | cpg: 50%; shore: 24%; shelf: 12%; other: 14% |
down syndrome | non-cancer disease | 4 | 4 | 25241 | Hyper: 56%; Hypo: 44%; NR: 0% | cpg: 10%; shore: 23%; shelf: 13%; other: 53% |
gestational diabetes mellitus | non-cancer disease | 10 | 13 | 8243 | Hyper: 38%; Hypo: 40%; NR: 23% | cpg: 32%; shore: 22%; shelf: 13%; other: 33% |
preterm birth | phenotype | 8 | 12 | 11628 | Hyper: 88%; Hypo: 12%; NR: 0% | cpg: 6%; shore: 21%; shelf: 16%; other: 57% |
rheumatoid arthritis (RA) | non-cancer disease | 8 | 13 | 4962 | Hyper: 50%; Hypo: 25%; NR: 25% | cpg: 18%; shore: 21%; shelf: 19%; other: 41% |
smoking | behavior | 69 | 88 | 73537 | Hyper: 41%; Hypo: 51%; NR: 8% | cpg: 14%; shore: 25%; shelf: 12%; other: 49% |
thyroid lesion | non-cancer disease | 1 | 1 | 1753 | Hyper: 87%; Hypo: 13%; NR: 0% | cpg: 19%; shore: 28%; shelf: 13%; other: 40% |
infertility | non-cancer disease | 5 | 5 | 7109 | Hyper: 70%; Hypo: 30%; NR: 0% | cpg: 11%; shore: 15%; shelf: 16%; other: 58% |
Probe ID | Studies | Correlations | Location | Related genes (transcript: location) | CpG islands | Related traits |
---|---|---|---|---|---|---|
cg20821042 | 3 | Hyper: 0%;Hypo: 67%;NR: 33% | chr6: 32709158 | HLA-DQA2 (ENST00000374940: promoter); | Other | |
cg26489369 | 2 | Hyper: 0%;Hypo: 100%;NR: 0% | chr6: 32709909 | HLA-DQA2 (ENST00000374940: promoter); | Other | |
cg14740554 | 2 | Hyper: 100%;Hypo: 0%;NR: 0% | chr6: 32713607 | HLA-DQA2 (ENST00000374940: body); | Other | |
cg06293782 | 2 | Hyper: 100%;Hypo: 0%;NR: 0% | chr6: 32713188 | HLA-DQA2 (ENST00000374940: body); | Other | |
cg02293354 | 1 | Hyper: 100%;Hypo: 0%;NR: 0% | chr6: 32711008 | HLA-DQA2 (ENST00000374940: body); | Other | |
cg17524162 | 1 | Hyper: 0%;Hypo: 0%;NR: 100% | chr6: 32714334 | HLA-DQA2 (ENST00000374940: body); | Other | |
cg00334532 | 1 | Hyper: 0%;Hypo: 100%;NR: 0% | chr6: 32712093 | HLA-DQA2 (ENST00000374940: body); | Other | |
cg03127506 | 1 | Hyper: 100%;Hypo: 0%;NR: 0% | chr6: 32710209 | HLA-DQA2 (ENST00000374940: promoter); | Other | |
cg22282941 | 1 | Hyper: 100%;Hypo: 0%;NR: 0% | chr6: 32709511 | HLA-DQA2 (ENST00000374940: promoter); | Other | |
cg02786267 | 1 | Hyper: 0%;Hypo: 0%;NR: 100% | chr6: 32708524 | HLA-DQA2 (ENST00000374940: promoter); | Other |
Gene ID | Location | Expression | #Association | Promoter/Body | Correlations | #Related Traits | Most Related traits (#Associations) |
---|---|---|---|---|---|---|---|
HLA-DQA2; ENSG00000237541 | (+) chr6:32709119-32714992 | 22 | body: 95%; promoter: 5% | Hyper: 41%; Hypo: 45%; NR: 14% | 17 |
PMID | Title | Year | Journal | Citation | Datasets |
---|---|---|---|---|---|
28428831 | Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns. | 2017 | Clin Epigenetics | 3 | |
26237075 | Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia. | 2015 | Epigenetics | 8 | GSE69229 |
29596946 | Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus. | 2018 | Diabetes Res Clin Pract | 2 | |
29601581 | Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates. | 2018 | PLoS One | 1 | |
29461653 | Epigenetic marks of in utero exposure to gestational diabetes and childhood adiposity outcomes: the EPOCH study. | 2018 | Diabet Med | 2 | |
28938489 | Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. | 2017 | J Clin Endocrinol Metab | 7 | GSE97466 |
26963385 | Pathway Implications of Aberrant Global Methylation in Adrenocortical Cancer. | 2016 | PLoS One | 11 | GSE19776 GSE77871 |
30183087 | Genome-wide DNA methylation profiling of primary colorectal laterally spreading tumors identifies disease-specific epimutations on common pathways. | 2018 | Int J Cancer | 0 | |
30176915 | Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins. | 2018 | Genome Med | 6 | |
30712078 | Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease. | 2019 | Acta Neuropathol | 0 | GSE125895 |