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Controlled clinical trials
Aug, 2001;22 (4): 453-79.

ACTIVE: a cognitive intervention trial to promote independence in older adults.

J B Jobe, D M Smith, K Ball, S L Tennstedt, M Marsiske, S L Willis, G W Rebok, J N Morris, K F Helmers, M D Leveck, K Kleinman
Author Information
  1. J B Jobe: Behavioral and Social Research Program, National Institute on Aging, Bethesda, MD, USA. jobej@nhlbi.nih.gov
PMID: 11514044 DOI: 10.1016/s0197-2456(01)00139-8

Abstract

The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial is a randomized, controlled, single-masked trial designed to determine whether cognitive training interventions (memory, reasoning, and speed of information processing), which have previously been found to be successful at improving mental abilities under laboratory or small-scale field conditions, can affect cognitively based measures of daily functioning. Enrollment began during 1998; 2-year follow-up will be completed by January 2002. Primary outcomes focus on measures of cognitively demanding everyday functioning, including financial management, food preparation, medication use, and driving. Secondary outcomes include health-related quality of life, mobility, and health-service utilization. Trial participants (n = 2832) are aged 65 and over, and at entry into the trial, did not have significant cognitive, physical, or functional decline. Because of its size and the carefully developed rigor, ACTIVE may serve as a guide for future behavioral medicine trials of this nature.

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Grants

  1. U01 AG014276-05S2/NIA NIH HHS
  2. U01 AG014276-05/NIA NIH HHS
  3. U01 AG014276-05S3/NIA NIH HHS
  4. U01 AG014276-08/NIA NIH HHS
  5. T32 AG000048/NIA NIH HHS
  6. U01 NR004508/NINR NIH HHS
  7. U01 AG014276-07S1/NIA NIH HHS
  8. U01 AG014276-04/NIA NIH HHS
  9. U01AG14276/NIA NIH HHS
  10. U01AG14260/NIA NIH HHS
  11. U01 AG014282/NIA NIH HHS
  12. U01 AG014260/NIA NIH HHS
  13. U01AG14263/NIA NIH HHS
  14. U01 AG014276/NIA NIH HHS
  15. U01 AG014263/NIA NIH HHS
  16. U01AG14282/NIA NIH HHS
  17. U01 AG014276-07/NIA NIH HHS
  18. U01 AG014276-08S1/NIA NIH HHS
  19. U01AG14289/NIA NIH HHS
  20. U01 AG014276-05S1/NIA NIH HHS
  21. R37 AG024102/NIA NIH HHS
  22. U01NR04508/NINR NIH HHS
  23. U01 AG014289/NIA NIH HHS
  24. U01 AG014276-06A1/NIA NIH HHS
  25. U01NR04507/NINR NIH HHS
  26. U01 NR004507/NINR NIH HHS

MeSH Term

Activities of Daily Living
Aged
Aged, 80 and over
Automobile Driving
Cognition Disorders
Cognitive Behavioral Therapy
Female
Follow-Up Studies
Health Status
Humans
Male
Mental Status Schedule
Outcome Assessment, Health Care
Physical Fitness
Quality of Life
Randomized Controlled Trials as Topic
Research Design
Vision, Ocular
Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial Research Support, U.S. Gov't, P.H.S.
Article has an altmetric score of 3

Word Cloud

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