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Antibiotics (Basel, Switzerland)
Mar 30, 2015;4 (2): 136-59.

Host Defense Peptides from Asian Frogs as Potential Clinical Therapies.

Vineeth T V Kumar, David Holthausen, Joshy Jacob, Sanil George
Author Information
  1. Vineeth T V Kumar: Molecular Ecology Lab, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala 695014, India. vineethkumartv@rgcb.res.in.
  2. David Holthausen: Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Yerkes National Primate Research Center, 954 Gatewood Rd, Atlanta, GA 30329, USA. dholtha@emory.edu.
  3. Joshy Jacob: Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Yerkes National Primate Research Center, 954 Gatewood Rd, Atlanta, GA 30329, USA. jjacob3@emory.edu.
  4. Sanil George: Molecular Ecology Lab, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala 695014, India. sgeorge@rgcb.res.in.
PMID: 27025618 DOI: 10.3390/antibiotics4020136

Abstract

Host Defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological membranes, and their peculiar mode of action. Even though HDPs from 60 Asian frog species belonging to 15 genera have been characterized, research into these peptides is at a very early stage. The purpose of this review is to showcase the status of peptide research in Asia. Here we provide a summary of HDPs from Asian frogs.

Keywords

Anti-microbial peptides Asian frog Host defense peptides Multi-drug resistance

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