Boosting Type 2 Immunity: When OX40L Comes from ILC2s.

Marina Babic, Chiara Romagnani
Author Information
  1. Marina Babic: Innate immunity, German Rheumatism Research Centre (DRFZ), a Leibniz Association, Berlin, Germany; Medical Department I, Charité-Universitätsmedizin, Berlin, Germany.
  2. Chiara Romagnani: Innate immunity, German Rheumatism Research Centre (DRFZ), a Leibniz Association, Berlin, Germany; Medical Department I, Charité-Universitätsmedizin, Berlin, Germany. Electronic address: romagnani@drfz.de.

Abstract

Accumulating evidence supports a role for the innate lymphoid cells (ILCs) in the modulation of T cell responses. In this issue of Immunity, Halim et al. (2018) identify a role for the costimulatory OX40-OX40L axis in ILC2-mediated regulation of adaptive type 2 immunity during helminth infection and allergen exposure.

MeSH Term

Adaptive Immunity
Humans
Immunity, Innate
Lymphocytes