Research progress on the mechanism and treatment of cachexia based on tumor microenvironment.
Bochen Zhao, Gege Shi, Jiaxin Shi, Zhaozhao Li, Yang Xiao, Yueyuan Qiu, Lei He, Fei Xie, Duo Yu, Haiyan Cao, Haichen Du, Jieyu Zhang, Yang Zhou, Caiyi Jiang, Weina Li, Meng Li, Zhaowei Wang
Author Information
Bochen Zhao: School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an, China.
Gege Shi: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Jiaxin Shi: School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an, China.
Zhaozhao Li: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Yang Xiao: Department of Experiment Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yueyuan Qiu: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Lei He: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Fei Xie: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Duo Yu: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Haiyan Cao: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Haichen Du: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Jieyu Zhang: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Yang Zhou: School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an, China.
Caiyi Jiang: School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an, China.
Weina Li: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Meng Li: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China.
Zhaowei Wang: State Key Laboratory of Cancer Biology, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, China. Electronic address: w1993zw@fmmu.edu.cn.
Cachexia is a prevalent multifactorial syndrome characterized by a substantial decrease in food intake, which results from processes such as proteolysis, lipolysis, inflammatory activation, and autophagy, ultimately leading to weight loss. In cancerpatients, this condition is referred to as cancer-related Cachexia (CRC) and affects over 50% of this population. A comprehensive understanding of the intricate interactions between tumors and the host organism is essential for the development of effective treatments for tumorCachexia. This review aims to elucidate the role of the tumor microenvironment (TME) in the pathogenesis of tumor-associated Cachexia and to summarize the current evidence supporting treatment modalities that target the TME.
