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Fei Yang
Fei Yang

Senior Engineer

Email: yangfei (AT) big.ac.cn

Tel: 010-84097298

Chinese Name: 杨飞

RESEARCH INTERESTS

  • Population Health and Immunosenescence from a Multi-Omics Perspective 

  • Advanced Integration and Computational Mining of Epigenomic Resources

  • Disease Causal Regulatory Network

WORK EXPERIENCE

  • Senior Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation CNCB, China, 2025.8 - Present

  • Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation CNCB, China, 2022.7 - 2025.7

EDUCATION

  • PhD in Bioinformatics, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2022

  • BS in Bioscience, Shandong University of Technology, China, 2016

HONORS & AWARDS

  • 2025年构建“面向人群复杂特征的高质量DNA甲基化数据集”入选国家数据局首批高质量数据集典型案例

  • 2025年获中国科学院智能知识库竞赛一等奖

  • 2024年获得CNCB-NGDC年度优秀员工（The "Outstanding Employee of CNCB-NGDC"）

  • 2023年获得CNCB-NGDC年度优秀员工（The "Outstanding Employee of CNCB-NGDC"）

  • 2023年共一成果获中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2023）

  • 2021年共一成果获中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2021）

  • 2020年共一成果获中国生物信息学十大进展（Top 10 Advances in Bioinformatics in China 2020）

PROJECTS & RESOURCES

FUNDING

  • 国家自然科学基金青年科学基金，表观组关联的因果图谱构建及精准干预应用，2024.01-2026.12，项目负责人

  • 中国科学院“十四五”网络安全和信息化专项，生物信息数据库体系建设工程，2024.8-2029.07，任务负责人

  • 国家自然科学基金委专项项目，免疫力大数据资源平台及关键技术研发，2026.1-2028.12，项目骨干

  • 国家自然科学基金委重大研究计划,跨尺度免疫力大数据资源平台及关键技术研发，2024.1-2027.12, 项目骨干

  • 国家重点研发计划青年科学家项目，科技文献文本内容的对象化知识表示与推理的关键技术与软件系统，2024.1-2026.12，课题骨干

  • 国家自然科学基金委青年科学基金项目，跨损伤合成聚合酶polη泛素化修饰的功能研究，2018.1-2020.12，参与

  • 国家自然科学基金委青年科学基金项目，长链非编码RNA调控DNA损伤修复参与乳腺癌化疗耐药的机制研究，2019.1-2021.12，参与


ACADEMIC ACTIVITIES

PUBLICATIONS

  1. Yang F#, Xiong Z#, Zong W#, Kong D#, Tang B, Chen X, Wei Y, Yu X, Zhang Y, Zou D, Zhang Z*, Bao Y*, Li R*. EWAS Open Platform 2026: a deeply integrated resource for epigenome-wide association studies.  Nucleic Acids Research. 2026 Jan 6;54(D1):D1061-D1068. doi: 10.1093/nar/gkaf1155.

  2. Yang F# as the co-first author in CNCB-NGDC Members and Partners: Database resources of the National Genomics Data Center, China National Center for Bioinformation in 2026. Nucleic Acids Research. 2026 Jan 6;54(D1):D28-D47. doi: 10.1093/nar/gkaf1172.

  3. Li H#, Zhao W#, Yang F#, Qiao Q#, Ma S#, Yang K#, Song S#, Wang S, Qu J, Liu GH, Bao Y, Zhang W. Immunosenescence Inventory-a multi-omics database for immune aging research. Nucleic Acids Research. 2025 Jan 6;53(D1):D1047-D1054. doi: 10.1093/nar/gkae1102. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39673270

  4. Shi M#, Yan Q#, Zhao W#, Teng C#, Han F, Chen H, Li Y, Xu L, Yang F, Yan Z, Ren Y, Jin G*, Bao Y*, Zuo C*, Li J*. NeoAtlas-Tumor and NeoBert: A Database and A Predictive Model for Canonical and Noncanonical Tumor Neoantigens. Genomics Proteomics Bioinformatics. 2025 Nov 12:qzaf105. doi: 10.1093/gpbjnl/qzaf105. Epub ahead of print.

  5. Yang F# as the co-first author in CNCB-NGDC Members and Partners:  Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025.Nucleic Acids Research. 2025 Jan 6;53(D1):D30-D44. doi: 10.1093/nar/gkae978. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39530327

  6. Yang F#, Guo X#, Bao Y*, Li R*. The role of ribosomal DNA methylation in embryonic development, aging and diseases. Epigenetics Chromatin. 2024 Jul 31;17(1):23. doi: 10.1186/s13072-024-00548-4. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39085958

  7. Yang F# as the co-first author in CNCB-NGDC Members and Partners: CNCB-NGDC Members and Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024. Nucleic Acids Research. 2024 Jan 5;52(D1):D18-D32. doi: 10.1093/nar/gkad1078. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-39085958

  8. Ma X#, Yang F#, Ma K#, et al. Ganoboninketal C from Ganoderma boninense improves the efficacy of CDDP-based chemotherapy through inhibiting translesion DNA synthesis. Food Science and Human Wellness, 2024 Sep;13(5):2982-2992. doi:10.26599/FSHW.2022.9250241

  9. Yang F# as the co-first author in CNCB-NGDC Members and Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Research. 2023 Jan 6;51(D1):D18-D28. doi: 10.1093/nar/gkac1073. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36420893

  10. Zhang M#, Zong W#, Zou D#, Wang G#, Zhang X, Guo X, Ma Y, Zhao W, Yang F, Wu S, Xiong Z, Zhang Z*, Bao Y*, Li R*, MethBank 4.0: an updated database of DNA methylation across a variety of species, Nucleic Acids Research, 2023,51(D1):D208-D216. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36318250

  11. Zheng X, Zong W, Li Z, Ma Y, Sun Y, Xiong Z, Wu S, Yang F, Zhao W, Bu C, Du Z, Xiao J, Bao Y. CCAS: One-stop and comprehensive annotation system for individual cancer genome at multi-omics level. Front Genet. 2022 Aug 11;13:956781. doi: 10.3389/fgene.2022.956781. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-36035123

  12. Yang F# as the co-first author in CNCB-NGDC Members and Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Nucleic Acids Research. 2022 Jan 7;50(D1):D27-D38. doi: 10.1093/nar/gkab951. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718731

  13. Wang G, Xiong Z, Yang F, Zheng X, Zong W, Li R, Bao Y. Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution. Genes (Basel). 2022 Jun 21;13(7):1109. doi: 10.3390/genes13071109. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-35885892

  14.  Xiong Z#, Yang F#, Li M#, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R*, Zhang Z*, Bao Y*. EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Research. 2022 Jan 7;50(D1):D1004-D1009. doi: 10.1093/nar/gkab972. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718752

  15. Yang F# as the co-first author in Aging Atlas Consortium. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021 Jan 8;49(D1):D825-D830. doi: 10.1093/nar/gkaa894. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33119753

  16. Xiong Z#, Li M#, Yang F#, Ma Y, Sang J, Li R, Li Z, Zhang Z, Bao Y. EWAS Data Hub: a resource of DNA methylation array data and metadata. Nucleic Acids Research. 2020 Jan 8;48(D1):D890-D895. doi: 10.1093/nar/gkz840. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31584095

  17. Yang F#  as the co-first author in CNCB-NGDC Members and Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Research. 2021Jan8;49(D1):D18-D28. doi: 10.1093/nar/gkaa1022. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33175170

  18. Yang F# as the co-first author in National Genomics Data Center Members and Partners. Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Research. 2020 Jan 8;48(D1):D24-D33. doi: 10.1093/nar/gkz913. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31702008

  19. 蔡凤香, 陈豆豆, 杨飞, 郑欣，张思韬，赵风云.镉锌互作条件下ABA对水稻幼苗根系生长和生长素分布的影响[J]. 江苏农业科学, 2016(3):74-77. 

  20. 陈豆豆, 杨飞, 蔡凤香,郑欣，张思韬，赵风云. 葡萄糖对水稻幼苗根系生长和生长素组织细胞分布的影响[J]. 江苏农业科学, 2016, 44(002):101-104.