The detail information of Factor VII deficiency
Basic Information

Disease Ontology ID: DDTO:0000403

Disease Description: A mild bleeding disease primarily of beagle dogs.

Inherit Mode: -

Disease Symptom: -

Disease Cause: Canine coagulation factor VII deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated.

Disease Diagnose: A canine specific factor VII ELISA is available to diagnose this condition.Routine coagulation screening tests can also be employed and unlike factor VIII or factor X deficiency, partial thromboplastin time in factor VII deficient dogs is usually normal.Treatment usually involves use of frozen fresh plasma or recombinant factor VII[8] is available in life-threatening situations.Use of recombinant factor VII offers only a temporary solution because the half-life of FVII protein is only 3 - 4 hours and, in canines, treatment with human proteins raises concern about antibody responses to those proteins, thus potentially limiting further therapy.Gene therapy has shown promise recently, but has been complicated by the canine immune response to adeno-associated viral gene transfer vector capsid proteins used in canine patients

Treat Method: -

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Factor VII deficiency - Autosomal Recessive -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB5 Alaskan Malamute Affectionate, loyal, playful but dignified 63.5 cm (male), 58.4 cm (female) 38.6 kg (male), 34 kg (female) United States
CB23 Bavarian Mountain Scent Hound Loyal, Versatile, Reserved with Strangers 17-20.5 inches 37-66 pound
CB25 Bearded Collie Bouncy, charismatic, friendly; smart, but also stubborn and independent 53.3-55.9 cm (male), 50.8-53.3 cm (female) 20.4-24.9 kg United Kingdom (Scotland)
Associated Disease Variants from OMIA
Gene Differential Expression
References
2019 Ramirez,C.J.,Krug,M.,Zahand,A.,Sundin,K.,Shaffer,L.G.,Ballif,B.C.: :
Canine factor VII deficiency: lessons learned in applying methods-based laboratory proficiency testing. J Vet Diagn Invest 31:276-279, 2019.
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2017 Keeshen,T.P.,Case,J.B.,Runge,J.J.,Singh,A.,Mayhew,P.D.,Steffey,M.A.,Culp,W.T.N.: :
Outcome of laparoscopic ovariohysterectomy or ovariectomy in dogs with von Willebrand disease or factor VII deficiency: 20 cases (2012-2014). J Am Vet Med Assoc 251:1053-1058, 2017.
Pubmed reference: 29035661 . DOI: 10.2460/javma.251.9.1053 .
2016 Donner,J.,Kaukonen,M.,Anderson,H.,Möller,F.,Kyöstilä,K.,Sankari,S.,Hytönen,M.,Giger,U.,Lohi,H.: :
Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders. PLoS One 11:e0161005, 2016.
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2013 Mayhew PD et al :
Evaluation of coagulation in dogs with partial or complete extrahepatic biliary tract obstruction by means of thromboelastography J Am Vet Med Assoc 242(6):778-785
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2012 Ogasawara S & Stokol T :
Interleukin-10 inhibits lipopolysaccharide-induced upregulation of tissue factor in canine peripheral blood monocytes Vet Immunol Immunopathol 148(3-4):331-336
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2011 Mischke,R.: :
Determination of canine coagulation factor VII. Vet J 190:305-6, 2011.
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2011 Knudsen T et al :
Canine specific ELISA for coagulation factor VII Vet J 190(3):352-358
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2011 Knudsen,T.,Kjelgaard-Hansen,M.,Tranholm,M.,Wiinberg,B.,Clausen,J.T.,Hansen,J.J.,Nichols,T.C.,Kjalke,M.,Jensen,A.L.,Kristensen,A.T.: :
Canine specific ELISA for coagulation factor VII. Vet J 190:352-8, 2011.
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2009 Reingardiene D & Lazauskas R :
Use of recombinant activated factor VII Medicina (Kaunas) 45(3):248-253
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2009 Nichols,TC.,Dillow,AM.,Franck,HW.,Merricks,EP.,Raymer,RA.,Bellinger,DA.,Arruda,VR.,High,KA.: :
Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J 50:144-67, 2009.
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2009 Carlstrom,LP.,Jens,JK.,Dobyns,ME.,Passage,M.,Dickson,PI.,Ellinwood,NM.: :
Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony. Comp Med 59:378-82, 2009.
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2009 Nichols TC et al :
Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency ILAR J 50(2):144-167
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2009 Carlstrom LP et al :
Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony Comp Med 59(4):378-382
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2007 Kaae JA et al :
Hereditary factor VII deficiency in the Alaskan klee kai dog J Vet Intern Med 21:976–981
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2007 Daly,M.L.,Giger,U.: :
A rodenticide exposed and bleeding beagle dog with hereditary factor VII deficiency J Vet Emerg Crit Care 17:170-174, 2007.
2007 Kaae,JA.,Callan,MB.,Brooks,MB.: :
Hereditary factor VII deficiency in the Alaskan Klee Kai dog. J Vet Intern Med 21:976-81, 2007.
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2006 Giger U & Withnall E :
Effects of a minute and regular dose of recombinant human activated factor VII in beagles with hereditary coagulation factor FVII deficiency ASH Annual Meeting Abstracts. Blood 108:1036
Pubmed reference: _ . DOI: _ .
2006 Callan,MB.,Aljamali,MN.,Margaritis,P.,Griot-Wenk,ME.,Pollak,ES.,Werner,P.,Giger,U.,High,KA.: :
A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost 4:2616-22, 2006.
Pubmed reference: 16961583 . DOI: 10.1111/j.1538-7836.2006.02203.x .
2006 Withnall,E.,Giger,U.: :
Effects of recombinant human activated factor VII and canine fresh frozen plasma in Beagles with hereditary coagulation factor VII deficiency Journal of Veterinary Internal Medicine 20:766 only, 2006.
2005 Callan,M.B.,Aljamali,M.N.,Griot-Wenkl,M.E.,Pollak,E.S.,Werner,P.,Giger,U.,High,K.A.: :
Molecular characterization of hereditary factor VII deficiency in the beagle Journal of Veterinary Internal Medicine 19:448-449 (abstract), 2005.
2003 Mischke,R.,Diedrich,M.,Nolte,I.: :
Sensitivity of different prothrombin time assays to factor VII deficiency in canine plasma Veterinary Journal 166:79-85, 2003.
1999 Macpherson,R.,Scherer,J.,Ross,M.L.,Gentry,P.A.: :
Factor VII deficiency in a mixed breed dog Canadian Veterinary Journal - Revue Veterinaire Canadienne 40:503-505, 1999.
1997 Mills,J.N.,Labuc,R.H.,Lawley,M.J.: :
Factor VII deficiency in an Alaskan Malamute Australian Veterinary Journal 75:320-322, 1997.
Pubmed reference: 9196814 .
1997 Mills JN et al :
Factor VII deficiency in an Alaskan malamute Aust Vet J 75:320–322
Pubmed reference: _ . DOI: _ .
1993 Brooks,M.,Catalfamo,J.: :
Buccal Mucosa Bleeding Time Is Prolonged in Canine Models of Primary Hemostatic Disorders Thrombosis and Haemostasis 70:777-780, 1993.
Pubmed reference: 8128434 .
1991 Ferguson,J.M.,MacGregor,I.R.,McLaughlin,L.F.,Prowse,C.V.: :
Use of factor VII-deficient beagles bred by artificial insemination to evaluate mechanisms of thrombosis associated with prothrombin complex concentrates. Blood Coagul Fibrinolysis 2:731-4, 1991.
Pubmed reference: 1799659 .
1991 Prydz,H.,Spurling,N.W.,Boyce,A.J.,Mifsud,C.V.J.: :
Phospholipase-C-Sensitive Factor-VII Complexes in Dog Plasma Thrombosis Research 64:387-394, 1991.
Pubmed reference: 1788825 .
1988 Fogh,J.M.,Fogh,I.T.: :
Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988.
Pubmed reference: 3282382 .
1988 Spurling,N.W.: :
Hereditary blood coagulation factor-VII deficiency: a comparison of the defect in Beagles from several sources Comparative Biochemistry and Physiology. A. Comparative Physiology 89:461-464, 1988.
Pubmed reference: 2896576 .
1988 VanderVelden,P.,Giles,A.R.: :
A detailed morphological evaluation of the evolution of the haemostatic plug in normal, factor VII and factor VIII deficient dogs. Br J Haematol 70:345-55, 1988.
Pubmed reference: 3207628 .
1987 Noguchi,M.,Fujii,T.,Michizono,A.: :
[Congenital deficiency of factor VII in a canine family] [Japanese] Experimental Animals 36:423-430, 1987.
Pubmed reference: 3436375 .
1986 Spurling,N.W.: :
Hereditary blood coagulation factor-VII deficiency in the Beagle: immunological characterisation of the defect Comparative Biochemistry and Physiology. A. Comparative Physiology 83:755-760, 1986.
Pubmed reference: 2870866 .
1984 Wheeler,S.L.,Weingand,K.W.,Thrall,M.A.,Berg,R.J.,Schwarz,P.D.: :
Persistent uterine and vaginal hemorrhage in a Beagle with factor-VII deficiency Journal of the American Veterinary Medical Association 185:447-448, 1984.
Pubmed reference: 6469849 .
1984 Wheeler SL et al :
Persistent uterine and vaginal hemorrhage in a with factor VII deficiency J Am Vet Med Assoc 185:447–448
Pubmed reference: _ . DOI: _ .
1980 Spurling,N.W.: :
Hereditary disorders of haemostasis in dogs: a critical review of the literature Veterinary Bulletin 50:151-173, 1980.
1974 Dodds,W.J.: :
Hereditary and acquired hemorrhagic disorders in animals. Prog Hemost Thromb 2:215-47, 1974.
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1974 Spurling,N.W.,Burton,L.K.,Pilling,T.: :
Canine factor-VII deficiency: experience with a modified thrombotest method in distinguishing between the genotypes. Res Vet Sci 16:228-39, 1974.
Pubmed reference: 4830986 .
1974 Spurling,N.W.,Peacock,R.,Pilling,T.: :
The clinical aspects of canine factor-VII deficiency including some case histories. J Small Anim Pract 15:229-39, 1974.
Pubmed reference: 4449220 .
1972 Spurberg,N.W.,Burton,L.K.,Peacock,R.,Pilling,T.: :
Hereditary factor VII deficiency in the Beagle British Journal of Haematology 23:59-67, 1972.
Pubmed reference: 5045961 .
1972 vonSchaewen,H.: :
[Thromboplastic activity of brain extracts from various species in normal plasma and in congenital factor VII deficient plasma from dogs]. Berl Munch Tierarztl Wochenschr 85:149-52, 1972.
Pubmed reference: 5027610 .
1970 Garner,R.,Conning,D.M.: :
The assay of human factor VII by means of modified factor VII deficient dog plasma British Journal of Maematology 18:57-66, 1970.
Pubmed reference: 5416591 .
1970 Hall,D.E.: :
Sensitivity of different thromboplastin reagents to factor VII deficiency in the blood of beagle dogs. Lab Anim 4:55-9, 1970.
Pubmed reference: 5527820 .
1968 Gaston,L.W.,Spivack,A.R.: :
Preparation of canine factor VII deficient substrate plasma. J Lab Clin Med 72:548-55, 1968.
Pubmed reference: 5677303 .
1967 Garner,R.,Hermoso-Perez,C.,Conning,D.M.: :
Factor VII deficiency in Beagle dog plasma and its use in the assay of human factor VII Nature 216:1130-1131, 1967.
Pubmed reference: 6075264 .
1962 Mustard,J.F.,Secord,D.,Hoeksema,T.D.,Downie,H.G.,Rowsell,H.C.: :
Canine factor-VII deficiency. Br J Haematol 8:43-7, 1962.
Pubmed reference: 14477610 .