The detail information of Hemivertebra
Basic Information

Disease Ontology ID: DDTO:0001106

Disease Description: A particular kind of malformation of the vertebra where only half of the structure is formed.

Inherit Mode: The condition is autosomal recessive in the German short-haired pointer and German shepherd. The mode of inheritance is unknown in other breeds.

Disease Symptom: A hemivertebra does not necessarily cause problemsfor your dog,unless it causes compression of the nerves (the spinal cord) withinthe spinal column.This may occur in two ways - the abnormally shaped vertebra may putpressure on the spinalcord directly, or it may be an unstable "weak link" in the vertebralcolumn.Spinal cord compression causes back pain, weakness or inability to getup or walk, andusually requires surgery.

Disease Cause: -

Disease Diagnose: Radiographs (x-rays) are necessary to diagnosehemivertebra. Yourveterinarian may discover that your dog has hemivertebra while takingx-rays for anotherpurpose. If your dog shows signs of spinal cord compression (backpain, weakness, orinability to get up or walk), special x-ray techniques (such as amyelogram) will show ifthe compression is caused by a hemivertebra.

Treat Method: Unless your dog has spinal cord compression, thereis no need totreat hemivertebra. Where there is spinal cord compression, your dogwill probably needsurgery.

Breeder Advice: It is best not to breed affected animals. Parentsof affected Germanshepherds and German short-haired pointers are carriers of the traitand should not bebred again.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Hemivertebrae - Multifactorial -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB46 Boston Terrier Friendly, bright, amusing, and adaptable. 38.1-43.2 cm 4.5-11.3 kg United States
CB58 English Bulldog Calm, courageous, and friendly; dignified but amusing. 35.6-38.1 cm 22.7 kg (male), 18.1 kg (female) United Kingdom (England)
CB88 Doberman Pinscher Alert, fearless, loyal, and highly trainable 66-71.1 cm (male), 61-66 cm (female) 34-45.4 kg (male), 27.2-40.8 kg (female) Germany
CB106 French Bulldog Playful, smart, adaptable, and completely irresistible 27.9-33 cm under 12.7 kg United Kingdom (England), France
CB110 German Shepherd Dog Smart, confident, courageous, and steady; a true dog lover's dog 61-66 cm (male), 55.9-61 cm (female) 29.5-40.8 kg (male), 22.7-31.8 kg (female) Germany
CB111 German Short-Haired Pointer Friendly, smart, willing to please 58.4-63.5 cm (male), 53.3-58.4 cm (female) 24.9-31.8 kg (male), 20.4-27.2 kg (female) Germany
CB196 Pug Even-tempered, charming, mischievous and loving 25.4-33 cm 6.4-8.2 kg China
CB205 Rottweiler Reserved with strangers and affectionate and loyal with his family. 61-68.6 cm (male), 55.9-63.5 cm (female) 49.9-59 kg (male), 34.9-49.9 kg (female) Germany
CB2 Afghan Hound Independent, sweet, silly 63.5-68.6 cm 22.7-27.2 kg Afghanistan
CB45 Borzoi(Russian wolfhound) Loyal, affectionate, regally dignified; a charming but independent-minded canine nobleman 71.1 cm & up (male), 66 cm & up (female) 34-47.6 kg (male), 27.2-38.6 kg (female) Russia
CB47 Bouvier des Flandres(Flanders Cattle Dog) Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders 62.2-69.9 cm (male), 59.7-67.3 cm (female) 31.8-49.9 kg Belgium
CB107 French Spaniel Friendly, outgoing personality, well balanced and patient,eager to please, can be trained easily France
Associated Disease Variants from OMIA
Gene Differential Expression
References
2015 Schlensker,E.,Distl,O.: :
Heritability of hemivertebrae in the French bulldog using an animal threshold model. Vet J :, 2015.
Pubmed reference: 26626092 . DOI: 10.1016/j.tvjl.2015.10.044 .
2014 Charalambous,M.,Jeffery,N.D.,Smith,P.M.,Goncalves,R.,Barker,A.,Hayes,G.,Ives,E.,Vanhaesebrouck,A.E.: :
Surgical treatment of dorsal hemivertebrae associated with kyphosis by spinal segmental stabilisation, with or without decompression. Vet J 202:267-73, 2014.
Pubmed reference: 25241946 . DOI: 10.1016/j.tvjl.2014.08.011 .
2007 Jeffery,N.D.,Smith,P.M.,Talbot,C.E.: :
Imaging findings and surgical treatment of hemivertebrae in three dogs. J Am Vet Med Assoc 230:532-6, 2007.
Pubmed reference: 17302550 . DOI: 10.2460/javma.230.4.532 .
2005 Besalti,O.,Ozak,A.,Pekcan,Z.,Eminaga,S.: :
Nasca classification of hemivertebra in five dogs. Ir Vet J 58:688-90, 2005.
Pubmed reference: 21851666 . DOI: 10.1186/2046-0481-58-12-688 .
1995 LeCouteur RA, Child G. :
Diseasesof the spinal cord W.B. Saunders Co., Toronto. EJEttinger and EC Feldman (eds.) Textbook of Veterinary InternalMedicine, pp. 629-696
1992 Bailey CS, Morgan JP. :
Congenital spinalmalformations Veterinary Clinics of North America Small Animal Practice 22(4):985-1015
1992 Bailey,C.S.,Morgan,J.P.: :
Congenital spinal malformations. Vet Clin North Am Small Anim Pract 22:985-1015, 1992.
Pubmed reference: 1641930 .
1989 Kirberger,RM.: :
Congenital malformation and variation of the lumbar vertebrae in a dog. 60:111-2, 1989.
Pubmed reference: 2607532 .
1982 Kramer,JW.,Schiffer,SP.,Sande,RD.,Rantanen,NW.,Whitener,EK.: :
Characterization of heritable thoracic hemivertebra of the German shorthaired pointer. 181:814-5, 1982.
Pubmed reference: 7141980 .
1980 Widmer,W.R.: :
Sublaxated hemivertebrae at T5, with spinal cord compression. J Am Vet Med Assoc 176:1017-8, 1980.
Pubmed reference: 7380715 .
1975 Done,S.H.,Drew,R.A.,Robins,G.M.,Lane,J.G.: :
Hemivertebra in the dog: clinical and pathological observations Veterinary Record 96:313-317, 1975.
Pubmed reference: 1129930 .
1969 Grenn,H.H.,Lindo,D.E.: :
Hemivertebrae with severe kypho-scoliosis and accompanying deformities in a dog. Can Vet J 10:214-6, 1969.
Pubmed reference: 5388275 .