Disease Ontology ID: DDTO:0000696
Disease Description: A disease where the blood vessels feeding the femoral head (top part of the thigh bone) shrink, leading to starvation and death of the femoral head (the ball of the ball-and-socket joint of the hip). Also called Legg-Calve'- Perthes disease.
Inherit Mode: A young dog affected with this disease will gradually develop pain and lameness in 1 hind leg, which slowly worsens over 3 or 4 weeks. The pain will become quite severe, and there is usually muscle shrinkage (atrophy) in the affected leg. This disease is treated quite successfully with surgery, so that your dog can live a normal pain-free life. If treated very early, surgery is sometimes not necessary.
Disease Symptom: Your veterinarian will suspect this disease if your young toy or small-breed dog shows signs of pain and lameness in the hip joint. Usually only one hip is affected, but occasionally both are involved. Depending on how far the disease has progressed, there may be muscle wasting (atrophy) in the affected limb. Radiographs will show whether your dog has the characteristic features of this disease, and also if there are other bony degenerative changes to the hip. Diagnosis is confirmed with a bone biopsy.
Disease Cause: -
Disease Diagnose: If diagnosed early (before much bony change to the head of the femur), the disease can sometimes be treated by pain relievers and by putting the hind leg in a sling for a period so that it doesn't bear weight. More often though, once pain and lameness are severe, the only treatment is to surgically remove the damaged (necrotic) head of the femur. This procedure effectively eliminates the source of the pain, and your dog should have a good quality of life thereafter.
Treat Method: If diagnosed early (before much bony change to the head of the femur), the disease can sometimes be treated by pain relievers and by putting the hind leg in a sling for a period so that it doesn't bear weight. More often though, once pain and lameness are severe, the only treatment is to surgically remove the damaged (necrotic) head of the femur. This procedure effectively eliminates the source of the pain, and your dog should have a good quality of life thereafter.
Breeder Advice: Affected dogs and their parents (considered carriers) should not be bred. Siblings are suspect carriers. A registry is maintained by the Institute for Genetic Disease Control in Animals (www.vetmed.ucdavis.edu/gdc/gdc.html) for Legg-Calvé-Perthes disease in terriers and miniature and toy poodles. Using the registry, breeders can select dogs for breeding with no family history of this disease.
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Legg-Calvé-Perthes disease | - | - | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB60 | Cairn Terrier | Cheerful, alert, busy and independent-minded | 25.4 cm (male), 24.1 cm (female) | 6.4 kg (male), 5.9 kg (female) | United Kingdom (Scotland) |
| CB149 | Lakeland Terrier | Brave, bright, confident; affectionate with family, especially kids | 35.6-38.1 cm (male), slightly smaller (female) | 7.7 kg (male), slightly smaller (female) | United Kingdom (England) |
| CB154 | Lowchen(Little Lion Dog) | Affectionate, Outgoing, Positive | 12-14 inches | 15 pounds | Germany, France, Netherlands, Spain |
| CB156 | Manchester Terrier | Spirited, bright, keenly observant; dead loyal, in an independent terrier way | 38.1-40.6 cm | 5.4-10 kg (standard) | United Kingdom (England) |
| CB160 | Miniature Pinscher | Fearless, Fun-Loving, Proud | 25.4-31.8 cm | 3.6-4.5 kg | Germany |
| CB196 | Pug | Even-tempered, charming, mischievous and loving | 25.4-33 cm | 6.4-8.2 kg | China |
| CB221 | Silky Terrier | Friendly, vivacious, cheeky; in all ways a true terrier | 22.9-25.4 cm | around 4.5 kg | Australia |
| CB255 | West Highland White Terrier | Happy, smart, loyal, entertaining | 27.9 cm (male). 25.4 cm, female | 6.8-9.1 kg | United Kingdom (Scotland) |
| CB257 | Wire-Haired Fox Terrier | Alert, quick of movement, keen of expression, on tiptoe of expectation at slightest provocation. Friendly, forthcoming and fearless. | 39 cm | 8.25 kg | United Kingdom (England) |
| CB262 | Yorkshire Terrier | Sprightly, tomboyish, and affectionate | 17.8-20.3 cm | 3.2 kg | United Kingdom (England) |
| CB268 | Miniature Poodle | Intelligent, Eager-to-please , Charming companion | 25-38 cm | 4.5-6.8kg | France&Germany |
| CB270 | Toy Poodle | Intelligent, eager to please, quick to learn and an affectionate, loyal pet. | under 25 cm | ||
| CB18 | Azawakh | Loyal, Independent, Deeply Affectionate | 25-29 inches (male), 23.5-27.5 inches (female) | 44-55 pounds (male), 33-44 pounds (female) | Mali |
| CB161 | Miniature Schnauzer | Friendly, smart, obedient | 30.5-35.6 cm | 5-9.1 kg | Germany |
| CB162 | Mountain Cur | Intelligent, Strong-Willed | 41-66cm | 13.6-27.2kg | United States |
| CB197 | Hungarian Puli | Loyal, smart, home-loving; strong-willed but trainable | 43.2 cm (male), 40.6 cm (female) | 11.3-15.9 kg | Hungary |
| CB213 | Scottish Deerhound | Dignified, gentle, polite; quietly intelligent and perceptive | 76.2-81.3 cm (male), 71.1 cm & up (female) | 38.6-49.9 kg (male), 34-43.1 kg (female) | United Kingdom (Scotland) |
| CB222 | Skye Terrier | Plucky but dignified, calm but sometimes stubborn; famously loyal and devoted | 25.4 cm (male), 24.1 cm (female) | 15.9-20.4 kg (male), slightly lighter (female) | United Kingdom (Scotland) |
| CB228 | Soft-Coated Wheaten Terrier | Happy, friendly, and deeply devoted; just stubborn enough to remind you they’re terriers | 45.7-48.3 cm (male), 43.2-45.7 cm (female) | 15.9-18.1 kg (male), 13.6-15.9 kg (female) | Ireland |
| CB256 | English Whippet | Calm, affectionate, and playful | 48.3-55.9 cm (male), 45.7-53.3 cm (female) | 11.3-18.1 kg | England |
| CB258 | Wire-Haired Pointing Griffon | Outgoing, eager, quick-minded; trustworthy in the field and around the house | Netherlands, France | ||
| CB263 | Akbash Dog | Calm, quiet, and steady.,independent ,loyal, gentle, and quietly affectionate with its own family, including children and family pets, but remains aloof and suspicious toward strangers. | 76.2-86.4 cm (male), 71.1-81.3 cm (female) | 54.4 kg (male), 40.8 kg (female) | Turkey |
| 2012 |
Starr-Moss,A.N.,Nowend,K.L.,Alling,K.M.,Zepp,E.J.,Murphy,K.E.: :
Exclusion of COL2A1 in canine Legg-Calvé-Perthes disease Anim Genet 43:112-3, 2012. Pubmed reference: 22221034 . DOI: 10.1111/j.1365-2052.2011.02215.x . |
| 2009 |
Scherzer,C.,Windhagen,H.,Nellesen,J.,Crostack,H.A.,Crostak,H.A.,Rohn,K.,Witte,F.,Thorey,F.,Fehr,M.,Hauschild,G.: :
Comparative structural analysis of the canine femoral head in Legg-Calvé-Perthes disease. Vet Radiol Ultrasound 50:404-11, 2009. Pubmed reference: 19697606 . |
| 2005 |
Demko,J.,McLaughlin,R.: :
Developmental orthopedic disease. Vet Clin North Am Small Anim Pract 35:1111-35, v, 2005. Pubmed reference: 16129135 . DOI: 10.1016/j.cvsm.2005.05.002 . |
| 2005 |
Isola,M.,Zotti,A.,Carnier,P.,Baroni,E.,Busetto,R.: :
Dual-energy X-ray absorptiometry in canine Legg-Calvé-Perthes disease. J Vet Med A Physiol Pathol Clin Med 52:407-10, 2005. Pubmed reference: 16176571 . DOI: 10.1111/j.1439-0442.2005.00746.x . |
| 2002 |
LaFond,E.,Breur,G.J.,Austin,C.C.: :
Breed susceptibility for developmental orthopedic diseases in dogs Journal of the American Animal Hospital Association 38:467-477, 2002. Pubmed reference: 12220032 . |
| 1999 |
Brenig,B.,Leeb,T.,Jansen,S.,Kopp,T.: :
Analysis of blood clotting factor activities in canine Legg-Calvé-Perthes' disease. J Vet Intern Med 13:570-3, 1999. Pubmed reference: 10587258 . |
| 1999 |
Ackerman L. :
The Genetic Connection: A Guide to Health Problems in Purebred Dogs AAHA Press,Lakewood, Colorado. pp.120-121 |
| 1998 |
Brunnberg,L.,Allgoewer,I.,Perslow,M.B.: :
Total hip replacement (mini tep) in small toy breeds - first clinical results [German] Kleintierpraxis 43:655 ff., 1998. |
| 1995 |
Bennett D, May C. :
Joint diseases of dogs and cats WB Saunders Co., Toronto EJ Ettinger and EC Feldman(eds). Textbook of Veterinary Internal Medicine, pp. 2032-2077 |
| 1995 |
Schrader SC :
Differential diagnosis of nontraumatic causes of lameness in young growing dogs WB Saunders Co., Toronto. JD Bonagura and RW Kirk(eds.) Kirk's Current Veterinary Therapy XII Small Animal Practice. p. 1171-1180 |
| 1995 |
Engelke,A.,Westhoff,A.,Meyerlindenberg,A.,Fehr,M.,Dammrich,K.,Nolte,I.: :
The Technique of Scintigraphy - A Picture Giving Method by Case Example of Morbus Legg-Calve-Perthes in the Dog Kleintierpraxis 40:49-54, 1995. |
| 1992 |
Robinson,R.: :
Legg-Calve-Perthes Disease in Dogs - Genetic Aetiology J Small Anim Pract 33:275-276, 1992. |
| 1990 |
Eichelberg,H.,Pohl,U.: :
Synopsis of Literature - Legg-Perthes Disease Kleintierpraxis 35:83-84, 1990. |
| 1989 |
Vasseur,P.B.,Foley,P.,Stevenson,S.,Heitter,D.: :
Mode of Inheritance of Perthes Disease in Manchester Terriers Clinical Orthopaedics and Related Research :281-292, 1989. Pubmed reference: 2743671 . |
| 1981 |
Mickelson,M.R.,McCurnin,D.M.,Awbrey,B.J.,Maynard,J.A.,Martin,R.K.: :
Legg-Calvé-Perthes disease in dogs: a comparison to human Legg-Culvé-Perthes disease. Clin Orthop Relat Res :287-300, 1981. Pubmed reference: 7249458 . |
| 1978 |
Pidduck,H.,Webbon,P.M.: :
The genetic control of Perthes' disease in Toy Poodles - a working hypothesis Journal of Small Animal Practice 19:729-733, 1978. Pubmed reference: 723237 . |
| 1972 |
Warren,DV.,Dingwall,JS.: :
Legg-Perthes disease in the dog--a review. Can Vet J 13:135-7, 1972. Pubmed reference: 5036901 . |
| 1971 |
Smith,K.W.: :
Legg-Perthes disease Veterinary Clinics of North America 1:479-487, 1971. Pubmed reference: 4949795 . |
| 1970 |
Lee,R.: :
A study of the radiographic and histological changes occurring in Legg-Calve-Perthes disease (LCP) in the dog. J Small Anim Pract 11:621-38, 1970. Pubmed reference: 5531150 . |
| 1969 |
Lee,R.,Fry,P.D.: :
Some observations on the occurance of Legg-Calvé-Perthes' disease (coxaplana) in the dog, and an evaluation of excision arthroplasty as a method of treatment. J Small Anim Pract 10:309-17, 1969. Pubmed reference: 5816741 . |
| 1969 |
Ljunggren,G.: :
Legg-Perthes disease in the dog. A case report with special reference to initial radiographic changes. Clin Orthop Relat Res 62:31-6, 1969. Pubmed reference: 5813190 . |
| 1967 |
Ljunggren,G.: :
Legg-Perthes disease in the dog. Acta Orthop Scand :Suppl 95:1-79, 1967. Pubmed reference: 6020301 . |
| 1967 |
Paatsama,S.,Rissanen,P.,Rokkanen,P.: :
Legg-Perthes disease in the dog: an experimental study using the histological and histochemical methods, oxytetracycline bone labelling technique autoradiography and microradiography Journal of Small Animal Practice 8:215-220, 1967. Pubmed reference: 6068724 . |
| 1953 |
Anderson,W.D.,Schlotthauer,C.F.: :
Leggs-Perthes' disease, coxa plana, in the dogs. J Am Vet Med Assoc 122:115-6, 1953. Pubmed reference: 13022568 . |