Disease Ontology ID: DDTO:0000810

Disease Description: Malabsorption refers to deficiency in the absorption of one or more nutrients in the gastrointestinal tract as a result of disruption of the normal process of digestion and absorption. Canine digestion and absorption of nutrients occur in three sequential phases: intraluminal digestion, mucosal digestion and absorption, and delivery of nutrients to the circulation.

Inherit Mode: -

Disease Symptom: Depending on the underlying cause, different breeds and ages are affected. There is a tremendous variation in spectrum and severity of signs. Soft stool or watery diarrhea Greasy stools Stools containing undigested food Increased frequency of defecation and stool volume Weight loss Increased or decreased appetite Depression Abdominal discomfort Borborygmus (noise coming from the gastrointestinal tract) Flatulence (gas) Vomiting

Disease Cause: Many diseases cause chronic malabsorption by interfering with these processes. Some of these include: Inflammatory bowel disease, a microscopic infiltration of the intestinal wall with inflammatory cells. The cause is unknown, although it is suspected to have an immune basis. Intestinal neoplasia, such as lymphosarcoma, adenocarcinoma and leiomyosarcoma Intestinal bacterial overgrowth, which is characterized by an overgrowth of normal intestinal flora (bacteria) usually secondary to various gastrointestinal diseases, but occasionally as a primary entity. Infectious enteropathies, such as bacterial, viral, fungal, parasitic, rickettsial Short bowel syndrome, which is created after a large portion of the intestinal tract is resected for any number of reasons. The remaining bowel is incapable of functioning normally, and malabsorption often develops. Lymphangiectasia, which is an obstructive (blockage) disorder involving the lymphatic system of the gastrointestinal tract. This results in protein being lost through the gastrointestinal tract and causes profound hypoproteinemia or low protein levels. Villous atrophy (wheat-sensitive enteropathy)

Disease Diagnose: A thorough knowledge of history and clinical signs is very important and is most helpful in the diagnosis of malabsorption. The following diagnostic tests may also be necessary: Complete blood count (CBC). Biochemical profile. Urinalysis. Fecal examination. Fecal bacterial cultures. Abdominal radiographs (x-rays). Radioimmunoassay of serum trypsinlike immunoreactivity (TLI), a blood test to rule out exocrine pancreatic insufficiency, a maldigestive disorder that often presents with similar signs. Folate and cobalamin (vitamin B12) levels, which are blood tests that assess for malabsorption and bacterial overgrowth. Endoscopic examination and biopsy

Treat Method: Treatment should be directed at the underlying cause, as different disorders require different therapy. Dietary modification. Pancreatic enzyme replacement. Antibiotic therapy. Anti-inflammatory therapy. Chemotherapy

Breeder Advice: Administer prescribed diet and medication. Follow patient closely for resolution of symptoms, especially diarrhea and body weight. If improvement is not appreciated over the first week or two, contact your veterinarian. There is no preventative available for malabsorptive disorders.

Disease Description Source: Link