Disease Ontology ID: DDTO:0000493
Disease Description: A rare cancer developing from a type of tissue cell known as a mast cell.
Inherit Mode: -
Disease Symptom: The mastocytoma is sometimes called as "the great deceiver" as it can show up with a wide range of appearances and clinical signs. The skin growths of mast cell tumors can be single or multiple, small and pale, or large, red and inflamed. They can be superficial or deeper in the dermis. The size of the growth may change. Those changes are the result of histamine release by the cancer. Touching or rubbing the growth may cause it to grow and become red and inflamed. Rarely, dogs will show signs of stomach upset and gastric ulcers such as vomiting and black stool. Interference with blood clotting and kidney inflammation are also seen.
Disease Cause: -
Disease Diagnose: -
Treat Method: Treatment of mast cell tumors employs a wide variety of techniques because of the stubborn nature of this type of tumors. Surgical removal of the affected and surrounding areas of the skin is usually the first step taken. Following surgical recovery, extensive radiation therapy and chemotherapy may be employed to help reduce the chances of recurrence and metastatic growth. Cryotherapy is also used in those instances in which surgical removal of the tumor is incomplete or impossible.
Breeder Advice: -
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Mast cell tumour | - | Multifactorial | - | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB45 | Borzoi(Russian wolfhound) | Loyal, affectionate, regally dignified; a charming but independent-minded canine nobleman | 71.1 cm & up (male), 66 cm & up (female) | 34-47.6 kg (male), 27.2-38.6 kg (female) | Russia |
| CB47 | Bouvier des Flandres(Flanders Cattle Dog) | Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders | 62.2-69.9 cm (male), 59.7-67.3 cm (female) | 31.8-49.9 kg | Belgium |
| CB49 | Boykin Spaniel | Friendly, eager, trainable, lovable | 39.4-45.7 cm (male), 35.6-41.9 cm (female) | 13.6-18.1 kg (male), 11.3-15.9 kg (female) | United States |
| CB58 | English Bulldog | Calm, courageous, and friendly; dignified but amusing. | 35.6-38.1 cm | 22.7 kg (male), 18.1 kg (female) | United Kingdom (England) |
| CB197 | Hungarian Puli | Loyal, smart, home-loving; strong-willed but trainable | 43.2 cm (male), 40.6 cm (female) | 11.3-15.9 kg | Hungary |
| CB253 | Welsh Springer Spaniel | Happy, upbeat, family oriented; reserved but not shy with strangers | 45.7-48.3 cm (male), 43.2-45.7 cm (female) | 18.1-24.9 kg (male), 15.9-22.7 kg (female) | United Kingdom (Wales) |
| 2019 |
Biasoli,D.,Compston-Garnett,L.,Ricketts,S.L.,Birand,Z.,Courtay-Cahen,C.,Fineberg,E.,Arendt,M.,Boerkamp,K.,Melin,M.,Koltookian,M.,Murphy,S.,Rutteman,G.,Lindblad-Toh,K.,Starkey,M.: :
A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers. PLoS Genet 15:e1007967, 2019. Pubmed reference: 30901340 . DOI: 10.1371/journal.pgen.1007967 . |
| 2019 |
Vozdova,M.,Kubickova,S.,Fictum,P.,Fröhlich,J.,Jelinek,F.,Rubes,J.: :
Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours. Vet J 247:71-74, 2019. Pubmed reference: 30971355 . DOI: 10.1016/j.tvjl.2019.03.005 . |
| 2015 |
Arendt,M.L.,Melin,M.,Tonomura,N.,Koltookian,M.,Courtay-Cahen,C.,Flindall,N.,Bass,J.,Boerkamp,K.,Megquir,K.,Youell,L.,Murphy,S.,McCarthy,C.,London,C.,Rutteman,G.R.,Starkey,M.,Lindblad-Toh,K.: :
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours. PLoS Genet 11:e1005647, 2015. Pubmed reference: 26588071 . DOI: 10.1371/journal.pgen.1005647 . |
| 2013 |
Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 . |
| 2013 |
Dobson,J.M.: :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139 . DOI: 10.1155/2013/941275 . |
| 2013 |
Warland,J.,Dobson,J.: :
Breed predispositions in canine mast cell tumour: A single centre experience in the United Kingdom. Vet J :, 2013. Pubmed reference: 23583004 . DOI: 10.1016/j.tvjl.2013.02.017 . |