The detail information of Optic nerve hypoplasia
Basic Information

Disease Ontology ID: DDTO:0000841

Disease Description: A condition where the optic nerve going from the eye to the brain is too small.

Inherit Mode: The mode of inheritance is unclear.

Disease Symptom: Depending on the degree of hypoplasia (underdevelopment), an eye may be partially or completely blind. Usually if only one eye is affected, your dog will compensate for the decreased vision to the point that you are unaware of any abnormality. You may notice that the pupils of your dog's eyes are different sizes - the pupil of the affected eye will be larger. If both eyes are affected, your dog will have some loss of sight or will be blind.

Disease Cause: -

Disease Diagnose: This condition is suspected when a dog is visually impaired from birth. Based on clinical and ophthalmoscopic examination, your veterinarian will determine if optic nerve hypoplasia is the cause. This condition must be distinguished from micropapilla, a normal variation of optic disc appearance where the disc is smaller but vision is normal.

Treat Method: There is no treatment. With their acute senses of smell and hearing, dogs can manage well despite reduced vision. You can help your visually impaired dog by developing regular routes for exercise, maintaining your dog's surroundings as consistently as possible, introducing any necessary changes gradually, and being patient.

Breeder Advice: Affected dogs and close relatives should not be used for breeding.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Optic nerve hypoplasia, bilateral - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB83 Dachshund Friendly, Curious, Spunky 20.3-22.9 cm (standard), 12.7-15.2 cm (miniature) 7.3-14.5 kg (standard), 5 kg & under (miniature) Germany
CB110 German Shepherd Dog Smart, confident, courageous, and steady; a true dog lover's dog 61-66 cm (male), 55.9-61 cm (female) 29.5-40.8 kg (male), 22.7-31.8 kg (female) Germany
CB120 Great Pyrenees Calm, patient, smart; strong-willed yet affectionate 68.6-81.3 cm (male), 63.5-73.7 cm (female) 45.4 kg & up (male), 38.6 kg & up (female) France, Spain
CB131 Irish Setter Outgoing, sweet-natured, active, and trainable 68.6 cm (male), 63.5 cm (female) 31.8 kg (male), 27.2 kg (female) Ireland
CB161 Miniature Schnauzer Friendly, smart, obedient 30.5-35.6 cm 5-9.1 kg Germany
CB167 Norfolk Terrier Alert, fearless, fun-loving, and more sociable than the usual terrier 22.9-25.4 cm 5-5.4 kg United Kingdom
CB232 St. Bernard Friendly, patient, outgoing; known as a great “nanny dog” for kids 71.1-76.2 cm (males), 66-71.1 cm (female) 63.5-81.6 kg (male), 54.4-63.5 kg (female) Italy, Switzerland
CB268 Miniature Poodle Intelligent, Eager-to-please , Charming companion 25-38 cm 4.5-6.8kg France&Germany
CB269 Standard Poodle Intelligent and quick-to-please 56-66 cm
CB270 Toy Poodle Intelligent, eager to please, quick to learn and an affectionate, loyal pet. under 25 cm
CB25 Bearded Collie Bouncy, charismatic, friendly; smart, but also stubborn and independent 53.3-55.9 cm (male), 50.8-53.3 cm (female) 20.4-24.9 kg United Kingdom (Scotland)
CB80 Coton de Tulear Bright, happy-go-lucky, endlessly charming; born to love and to be loved 25.4-27.9 cm (male), 22.9-25.4 cm (female) 4.1-6.8 kg (male), 3.6-5.9 kg (female) Madagascar
CB98 English Toy Spaniel Affectionate, Alert, Merry 22.9-25.4 cm 3.6-6.4 kg England
CB111 German Short-Haired Pointer Friendly, smart, willing to please 58.4-63.5 cm (male), 53.3-58.4 cm (female) 24.9-31.8 kg (male), 20.4-27.2 kg (female) Germany
CB117 Gordon Setter Bold, confident, and resolute afield; sweetly affectionate by the fireside 61-68.6 cm (male), 58.4-66 cm (female) 24.9-36.3 kg (male), 20.4-31.8 kg (female) United Kingdom (Scotland)
CB123 Hamiltonstovare(Hamilton Hound) Agile, Versatile, Regal 53-61cm (male) 49-57cm (female) 18-26kg Sweden
CB132 Irish Terrier Bold, dashing, even reckless; stouthearted at work, tenderhearted at home 45.7 cm 12.2 kg (male), 11.3 kg (female) Ireland
CB136 German Jagdterrier Courageous, Intelligent, Hardworking 33-40cm 7.7-9.9kg Germany
CB217 Japanese Shiba Inu Alert, active, and attentive 35.6-43.2 cm (male), 33-40.6 cm (female) 8.2-10.9 kg (male), 6.8-9.1 kg (female) Japan
CB229 Spanish Mastiff Aloof, dignified, calm and intelligent Spain
CB183 Pharaoh Hound Smart and alert; noble, but friendly and affectionate 58.4-63.5 cm (male), 53.3-61 cm (female) 20.4-24.9 kg Malta
Associated Disease Variants from OMIA
Gene Differential Expression
References
2008 daSilva,E.G.,Dubielzig,R.,Zarfoss,M.K.,Anibal,A.: :
Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol 11:23-9, 2008.
Pubmed reference: 18190348 . DOI: 10.1111/j.1463-5224.2007.00596.x .
1999 Ackerman, L. :
The genetic connection AAHA Press p 159-160
1999 Ackerman L. :
The Genetic Connection: A Guide to Health Problemsin Purebred Dogs AAHA Press,Lakewood, Colorado p. 126
1998 Termote,S.: :
What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract 39:1, 39, 1998.
Pubmed reference: 9494926 .
1981 Kern,T.J.,Riis,R.C.: :
Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc 178:49-54, 1981.
Pubmed reference: 7204223 .
1976 Ernest,J.T.: :
Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc 168:125-8, 1976.
Pubmed reference: 1245453 .
1971 Gelatt,K.N.,Leipold,H.W.: :
Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J 12:91-6, 1971.
Pubmed reference: 5104935 .
1952 Saunders,L.Z.: :
Congenital optic nerve hypoplasia in Collie dogs Cornell Veterinarian 42:67-80, 1952.
Pubmed reference: 14905886 .