Disease Ontology ID: DDTO:0000486
Disease Description: As subaortic stenosis, but the tightening occurs below the aortic valve.
Inherit Mode: -
Disease Symptom: Symptoms may include but are not limited to: Lethargy ;Syncope (fainting, loss of consciousness); Exercise intolerance; Systolic heart murmur; Weak femoral pulse ;Sudden death
Disease Cause: Subvalvular aortic stenosis is caused by a ridge or ring of fibrous tissue or by fibrous nodules within the left ventricular outflow tract located just below the aortic valve. It is most commonly seen in Boxers, Rottweilers, German Shepherds, Newfoundlands, and Golden Retrievers. It can be a congenital condition, meaning the animal was born with it, or it can develop as he ages.
Disease Diagnose: An electrocardiogram may be able to show the left ventricular enlargement. Doppler echocardiography can also confirm the aortic stenosis if present. The velocity of the systolic blood flow determines the severity of the stenosis. An ultrasound may also be utilized during the diagnostic process. It can show the different chambers of the heart and offer a live feed of the heart pumping. It can allow the veterinarian to see where the flow of blood is altered and by how much. There are other diagnostic imagings your veterinarian may recommend, however you may have to go to a specialist for it. In veterinary medicine, there are cardiologists available that may be better equipped to handle your dog’s case.
Treat Method: Treatment for subvalvular aortic stenosis can be by medical management or by surgical correction.There are also herbal medication, homeopathic remedies, and Chinese holistic medications you can look into in addition to western medicine. This would require you to go to a holistic veterinarian who is practiced in the field, but it can be an extremely beneficial option for your dog. In some cases, you may even utilize a combination of western medicine and holistic medicine for the best treatment plan for him.
Breeder Advice: Some animals show no symptoms of this condition. Ones who are mildly affected typically do not even need treatment. Prognosis in these animals can range from fair to good. For those with a more serious condition, prognosis declines and can become guarded to poor. It is highly recommended animals with this condition are not bred as it is genetic.
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Aortic stenosis, subvalvular | - | - | - | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB26 | Beauceron(French Short-Haired Shepherd Dog) | Smart, obedient, gentle; reserved with strangers, loving and eager to please with preferred humans | 64.8-69.9 cm (male), 61-67.3 cm (female) | 31.8-49.9 kg | France |
| 2021 |
Ontiveros,E.S.,Stern,J.A.: :
Genetics of canine subvalvular aortic stenosis (SAS). Canine Med Genet 8:4, 2021. Pubmed reference: 33962679 . DOI: 10.1186/s40575-021-00103-4 . |
| 2020 |
Brambilla,P.G.,Polli,M.,Pradelli,D.,Papa,M.,Rizzi,R.,Bagardi,M.,Bussadori,C.: :
Epidemiological study of congenital heart diseases in dogs: Prevalence, popularity, and volatility throughout twenty years of clinical practice. PLoS One 15:e0230160, 2020. Pubmed reference: 32716943 . DOI: 10.1371/journal.pone.0230160 . |
| 2017 |
Belanger,J.M.,Bellumori,T.P.,Bannasch,D.L.,Famula,T.R.,Oberbauer,A.M.: :
Correlation of neuter status and expression of heritable disorders. Canine Genet Epidemiol 4:6, 2017. Pubmed reference: 28560045 . DOI: 10.1186/s40575-017-0044-6 . |
| 2015 |
Oberbauer,A.M.,Belanger,J.M.,Bellumori,T.,Bannasch,D.L.,Famula,T.R.: :
Ten inherited disorders in purebred dogs by functional breed groupings. Canine Genet Epidemiol 2:9, 2015. Pubmed reference: 26401337 . DOI: 10.1186/s40575-015-0021-x . |
| 2015 |
Schrope,D.P.: :
Prevalence of congenital heart disease in 76,301 mixed-breed dogs and 57,025 mixed-breed cats. J Vet Cardiol 17:192-202, 2015. Pubmed reference: 26363941 . DOI: 10.1016/j.jvc.2015.06.001 . |
| 2013 |
Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 . |
| 2011 |
Oliveira,P.,Domenech,O.,Silva,J.,Vannini,S.,Bussadori,R.,Bussadori,C.: :
Retrospective Review of Congenital Heart Disease in 976 Dogs. J Vet Intern Med :, 2011. Pubmed reference: 21418326 . DOI: 10.1111/j.1939-1676.2011.0711.x . |
| 2009 |
Bussadori,C.,Pradelli,D.,Borgarelli,M.,Chiavegato,D.,D'Agnolo,G.,Menegazzo,L.,Migliorini,F.,Santilli,R.,Zani,A.,Quintavalla,C.: :
Congenital heart disease in boxer dogs: results of 6 years of breed screening. Vet J 181:187-92, 2009. Pubmed reference: 18400530 . DOI: 10.1016/j.tvjl.2008.02.008 . |
| 2007 |
Höglund,K.,Bussadori,C.,Domenech,O.,Häggström,J.,Pradelli,D.,Kvart,C.: :
Contrast echocardiography in Boxer dogs with and without aortic stenosis. J Vet Cardiol 9:15-24, 2007. Pubmed reference: 17689465 . DOI: 10.1016/j.jvc.2006.02.003 . |
| 2006 |
Linde,A.,Koch,J.: :
Screening for aortic stenosis in the Boxer: Auscultatory, ECG, blood pressure and Doppler echocardiographic findings. J Vet Cardiol 8:79-86, 2006. Pubmed reference: 19083341 . DOI: 10.1016/j.jvc.2006.02.002 . |
| 2002 |
Schober,KE.,Fuentes,VL.: :
Doppler echocardiographic assessment of left ventricular diastolic function in 74 boxer dogs with aortic stenosis. J Vet Cardiol 4:7-16, 2002. Pubmed reference: 19081341 . DOI: 10.1016/S1760-2734(06)70018-2 . |
| 2000 |
Heiene,R.,Kvart,C.,Indrebo,A.,Skaalnes,H.M.,Ulstad,A.K.: :
Prevalence of murmurs consistent with aortic stenosis among boxer dogs in Norway and Sweden Veterinary Record 147:152-156, 2000. Pubmed reference: 10975330 . |
| 2000 |
French,A.,Fuentes,V.L.,Dukes-McEwan,J.,Darke,P.G.G.,Martin,M.,Corcoran,B.: :
Progression of aortic stenosis in the boxer Journal of Small Animal Practice 41:451-456, 2000. Pubmed reference: 11072913 . |
| 1998 |
Delpalacio,M.J.F.,Bayon,A.,Bernal,L.J.,Ceron,J.J.,Navarro,J.A.: :
Clinical and pathological findings of severe subvalvular aortic stenosis and mitral dysplasia in a rottweiler puppy Journal of Small Animal Practice 39:481-485, 1998. Pubmed reference: 9816571 . |
| 1998 |
Kvart,C.,French,A.T.,Fuentes,V.L.,Haggstrom,J.,Mcewan,J.D.,Schober,K.E.: :
Analysis ofmurmur intensity, duration and frequency components in dogs with aortic stenosis Journal of Small Animal Practice 39:318-324, 1998. Pubmed reference: 9693417 . |
| 1997 |
Monnet,E.: :
Open resection for subvalvular aortic stenosis in dogs (vol 209, pg 1255, 1996) Journal of the American Veterinary Medical Association 210:92, 1997. |
| 1997 |
Tidholm,A.: :
Retrospective study of congenital heart defects in 151 dogs Journal of Small Animal Practice 38:94-98, 1997. Pubmed reference: 9097239 . |
| 1997 |
White,R.N.,Boswood,A.,Garden,O.A.,Hammond,R.A.: :
Surgical management of subvalvular aortic stenosis and mitral dysplasia in a golden retriever Journal of Small Animal Practice 38:251-255, 1997. Pubmed reference: 9200115 . |
| 1995 |
Skarda,R.T.,Bednarski,R.M.,Muir,W.W.,Hubbell,J.A.E.,Mason,D.E.: :
Sedation and anesthesia in dogs and cats with cardiovascular disease Schweizer Archiv Fur Tierheilkunde 137:312-321, 1995. Pubmed reference: 7569846 . |
| 1994 |
Buoscio,D.A.,Sisson,D.,Zachary,J.F.,Luethy,M.: :
Clinical and Pathological Characterization of an Unusual Form of Subvalvular Aortic Stenosis in 4 Golden Retriever Puppies Journal of the American Animal Hospital Association 30:100-110, 1994. |
| 1989 |
Muir,G.D.,Panciera,D.L.,Fowler,J.D.,Bharadwaj,B.B.,Burrows,P.: :
Medical and Surgical Management of Aortic Stenosis in a Dog Canadian Veterinary Journal-Revue Veterinaire Canadienne 30:894-896, 1989. |
| 1989 |
O'Grady,M.R.,Holmberg,D.L.,Miller,C.W.,Cockshutt,J.R.: :
Canine Congenital Aortic Stenosis - A Review of the Literature and Commentary Canadian Veterinary Journal-Revue Veterinaire Canadienne 30:811-815, 1989. |
| 1973 |
Mulvihill,J.J.,Priester,W.A.: :
Congenital heart disease in dogs: epidemiologic similarities to man. Teratology 7:73-7, 1973. Pubmed reference: 4693746 . DOI: 10.1002/tera.1420070111 . |
| 1971 |
Rudolph,R.: :
[Subvalvular aortic stenosis in a 4-year-old female German boxer]. Berl Munch Tierarztl Wochenschr 84:374-5, 1971. Pubmed reference: 5107230 . |