The detail information of Syringomyelia
Basic Information

Disease Ontology ID: DDTO:0000326

Disease Description: Developmental abnormalities causing cavities within the spinal cord, probably just an effect of #289. Common in Rhodesian ridgebacks.

Inherit Mode: -

Disease Symptom: Clinical signs include progressive weakness in the forelimbs and episodes of involuntary scratching of the flank. The dog's forelimbs would slide on a slippery surface and he would be unable to correct this posture. Since the spinal cord connects the brain to the nerves in the extremities, this damage may result in pain, weakness, and stiffness in the back or legs.

Disease Cause: Syringomyelia may result from a congenital defect of the neural tube or trauma to the spinal cord, such as a car accident or serious fall.

Disease Diagnose: The syrinx is diagnosed using an MRI test.

Treat Method: With increasing use of MRI and increased awareness of syringomyelia complex, early detection may enable surgical resolution of this potentially debilitating neurological disease. Further studies may also shed light on the heritability of this disease, as it has been reported as a genetic disorder in the King Charles Spaniel. In this breed, syringomyelia occurs as a result of inherited occipital hypoplasia/Chiari type I malformation.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Syringomyelia - Multifactorial -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB252 Weimaraner Friendly, fearless, alert, obedient 63.5-68.6 cm (male), 58.4-63.5 cm (female) 31.8-40.8 kg (male), 24.9-34 kg (female) Germany
CB253 Welsh Springer Spaniel Happy, upbeat, family oriented; reserved but not shy with strangers 45.7-48.3 cm (male), 43.2-45.7 cm (female) 18.1-24.9 kg (male), 15.9-22.7 kg (female) United Kingdom (Wales)
Associated Disease Variants from OMIA
Gene Differential Expression
References
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2019 Thoefner,M.S.,Westrup,U.,Toft,N.,Bjerrum,O.J.,Berendt,M.: :
Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs. Vet J 246:92-97, 2019.
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2017 Knowler,S.P.,Kiviranta,A.M.,McFadyen,A.K.,Jokinen,T.S.,LaRagione,R.M.,Rusbridge,C.: :
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2017 Wijnrocx,K.,VanBruggen,L.W.L.,Eggelmeijer,W.,Noorman,E.,Jacques,A.,Buys,N.,Janssens,S.,Mandigers,P.J.J.: :
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2015 Thøfner,M.S.,Stougaard,C.L.,Westrup,U.,Madry,A.A.,Knudsen,C.S.,Berg,H.,Jensen,C.S.,Handby,R.M.,Gredal,H.,Fredholm,M.,Berendt,M.: :
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2015 Wrzosek,M.,Płonek,M.,Nicpoń,J.,Cizinauskas,S.,Pakozdy,A.: :
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2014 Knowler,S.P.,McFadyen,A.K.,Freeman,C.,Kent,M.,Platt,S.R.,Kibar,Z.,Rusbridge,C.: :
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2014 Mitchell,T.J.,Knowler,S.P.,vandenBerg,H.,Sykes,J.,Rusbridge,C.: :
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2013 Driver,C.J.,Watts,V.,Bunck,A.C.,VanHam,L.M.,Volk,H.A.: :
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2013 Fenn,J.,Schmidt,M.J.,Simpson,H.,Driver,C.J.,Volk,H.A.: :
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2011 Knowler,S.P.,McFadyen,A.K.,Rusbridge,C.: :
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2011 Parker,J.E.,Knowler,S.P.,Rusbridge,C.,Noorman,E.,Jeffery,N.D.: :
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2010 Lewis,T.,Rusbridge,C.,Knowler,P.,Blott,S.,Woolliams,JA.: :
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2010 Wolfe,KC.,Poma,R.: :
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2009 Carruthers,H.,Rusbridge,C.,Dubé,M.P.,Holmes,M.,Jeffery,N.: :
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2009 Cerda-Gonzalez,S.,Olby,NJ.,Broadstone,R.,McCullough,S.,Osborne,JA.: :
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2009 Mandigers,P.,Rusbridge,C.: :
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2009 Park,C.,Kang,BT.,Yoo,JH.,Park,HM.: :
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2009 Rusbridge,C.,Knowler,SP.,Pieterse,L.,McFadyen,AK.: :
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2008 Chandler,K.,Volk,H.,Rusbridge,C.,Jeffery,N.: :
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2008 Stalin,CE.,Rusbridge,C.,Granger,N.,Jeffery,ND.: :
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2008 Kitagawa,M.,Ueno,H.,Watanabe,S.,Igarashi,O.,Uzuka,Y.,Kanayama,K.,Sakai,T.: :
Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J 86:36-42, 2008.
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2008 Rusbridge,C.,Jeffery,ND.: :
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2007 Rusbridge,C.,Carruthers,H.,Dubé,M.P.,Holmes,M.,Jeffery,N.D.: :
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2006 Jung,DI.,Park,C.,Kang,BT.,Kim,JW.,Kim,HJ.,Lim,CY.,Jeong,SW.,Park,HM.: :
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2006 MacKillop,E.,Schatzberg,SJ.,deLahunta,A.: :
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2006 Rusbridge,C.,Greitz,D.,Iskandar,BJ.: :
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2006 Rusbridge,C.,Knowler,SP.: :
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2005 Rusbridge,C.,Knowler,P.,Rouleau,GA.,Minassian,BA.,Rothuizen,J.: :
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2005 Takagi,S.,Kadosawa,T.,Ohsaki,T.,Hoshino,Y.,Okumura,M.,Fujinaga,T.: :
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2005 Hasegawa,T.,Taura,Y.,Kido,H.,Shibazaki,A.,Katamoto,H.: :
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2004 Rusbridge,C.,Knowler,SP.: :
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2000 Bagley,R.S.,Gavin,P.R.,Silver,G.M.,Moore,M.P.,Kippenes,H.,Connors,R.: :
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2000 Rusbridge,C.,MacSweeny,J.E.,Davies,J.V.,Chandler,K.,Fitzmaurice,S.N.,Dennis,R.,Cappello,R.,Wheeler,S.J.: :
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2000 Taga,A.,Taura,Y.,Nakaichi,M.,Wada,N.,Hasegawa,T.: :
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1996 Itoh,T.,Nishimura,R.,Matsunaga,S.,Kodosawa,T.,Mochizuki,M.,Sasaki,N.: :
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1973 Furneaux,R.W.,Doige,C.E.,Kaye,M.M.: :
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1965 McGrath,J.T.: :
Spinal dysraphism in the dog, with comments on syringomylia Pathologia Veterinaria 2:1-36 (Supplement), 1965.
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