Disease Ontology ID: DDTO:0000670

Disease Description: Cyclic hematopoiesis is a genetic disorder of the immune system of Collie dogs, and is also referred to as cyclic neutropenia and gray collie syndrome

Inherit Mode: The mode of inheritance is autosomal recessive.Both parents must carry the abnormal gene for the offspring to be affected.

Disease Symptom: This is a serious disorder. These dogs are subject to severe recurring bacterial infections, primarily of the respiratory or gastrointestinal tract. Even with the best of care, affected dogs rarely live beyond 2 or 3 years of age.

Disease Cause: -

Disease Diagnose: Affected dogs have a light silver gray, possibly mixed with light beige, hair coat and a characteristic light coloured nose. Pups usually experience clinical illness by 8 to 12 weeks of age and are brought to the veterinarian at that time, if the breeder does not recognize the defect before then. The disorder is diagnosed based on the cyclic fluctuation in blood cell numbers, as well as the characteristic coat coloration.

Treat Method: Other than bone marrow transplantation, which is impractical, there is no effective treatment. Without supportive care, pups usually die before 6 months of age. Even with the best of care, including very close monitoring and antibiotics to counteract the variety of infections, these dogs usually die before 2 or 3 years of age.

Breeder Advice: Parents and littermates of affected dogs should not be used for breeding, to avoid perpetuating this lethal defect.

Disease Description Source: Link