Disease Ontology ID: DDTO:0000967

Disease Description: With this condition there are skin changes due to a lack of growth hormone (somatotropin). This hormone is secreted by the pituitary gland and is necessary for hair growth and the maintenance of normal elasticity of the skin.

Inherit Mode: A mode of inheritance has not been established; however the disorder is mostly seen in the breeds listed below.

Disease Symptom: This condition is more common in male dogs between 1 and 5 years of age, with hair loss usually starting at puberty. Adrenal sex-hormone dermatosis is seen in males and females, either neutered or intact. Hair loss (called alopecia) is symmetrical over the trunk of the dog and the skin is markedly darker in color due to increased pigmentation. Without treatment, hairlessness and hyperpigmentation will eventually spread over your dog's body except for head and feet. The condition does not affect the health of your dog, only his/her appearance.

Disease Cause: -

Disease Diagnose: There are several possible hormonal causes of hair loss in dogs. Your veterinarian will do tests to determine the cause in your pet.

Treat Method: As mentioned, this condition does not affect the health of your dog, only his/her appearance. It can be treated with growth hormone (GH), but this is expensive and can be difficult to obtain. Treated dogs must be monitored for the development of diabetes mellitus which is a potential side effect of GH therapy. Castration may resolve the condition in male dogs. Similarly, neutering of affected male or female dogs may help to treat adrenal sex-hormone imbalance. If ineffective, there are medical treatments that may be beneficial (opDDD or mitotane, and ketoconazole).

Breeder Advice: Although little is known about the inheritance of this disorder, it is prudent to avoid breeding affected animals or their close relatives.

Disease Description Source: Link