Disease Ontology ID: DDTO:0000034
Disease Description: Osteochondrodysplasia describes a range of disorders which are characterized by abnormal growth of cartilage and bone.
Inherit Mode: -
Disease Symptom: This condition is autosomal recessivein several of the breeds in which it occurs.
Disease Cause: -
Disease Diagnose: There is a range in the severity of problemscaused by thiscondition. Mildly affected dogs may have short stature due to shortlimbs, with noassociated clinical problems. Progressively more severe effectsinclude bowed limbs, orlimbs which are angled to the side, enlarged and deformed joints,joint looseness,lameness, decreased ability to exercise, and severe debilitation.Animals with thiscondition are more likely to develop arthritis and joint pain.
Treat Method: Your veterinarian will make this diagnosis based onyour dog'sphysical appearance; x-rays may be taken to confirm the diagnosis, orto screen puppiesless than 13 weeks of age for this condition.
Breeder Advice: -
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Osteochondrodysplasia | Also known as pseudoachondroplastic dysplasia | Autosomal Recessive | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB5 | Alaskan Malamute | Affectionate, loyal, playful but dignified | 63.5 cm (male), 58.4 cm (female) | 38.6 kg (male), 34 kg (female) | United States |
| CB120 | Great Pyrenees | Calm, patient, smart; strong-willed yet affectionate | 68.6-81.3 cm (male), 63.5-73.7 cm (female) | 45.4 kg & up (male), 38.6 kg & up (female) | France, Spain |
| CB147 | Labrador Retriever | Friendly and outgoing, Labs play well with others | 57.2-62.2 cm (male), 54.6-59.7 cm (female) | 29.5-36.3 kg (male), 24.9-31.8 kg (female) | Canada, United Kingdom (England) |
| CB170 | Norwegian Elkhound | Confident, dependable; dignified but friendly | 52.1 cm (male), 49.5 cm (female) | 24.9 kg (male), 21.8 kg (female) | Norway |
| CB210 | Samoyed | Gentle, adaptable, eager, friendly; conservative but never shy | 53.3-59.7 cm (male), 48.3-53.3 cm (female) | 20.4-29.5 kg (male), 15.9-22.7 kg (female) | Russia |
| CB213 | Scottish Deerhound | Dignified, gentle, polite; quietly intelligent and perceptive | 76.2-81.3 cm (male), 71.1 cm & up (female) | 38.6-49.9 kg (male), 34-43.1 kg (female) | United Kingdom (Scotland) |
| 2012 |
Jackson,G.C.,Mittaz-Crettol,L.,Taylor,J.A.,Mortier,G.R.,Spranger,J.,Zabel,B.,LeMerrer,M.,Cormier-Daire,V.,Hall,C.M.,Offiah,A.,Wright,M.J.,Savarirayan,R.,Nishimura,G.,Ramsden,S.C.,Elles,R.,Bonafe,L.,Superti-Furga,A.,Unger,S.,Zankl,A.,Briggs,M.D.: :
Pseudoachondroplasia and multiple epiphyseal dysplasia: a 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution. Hum Mutat 33:144-57, 2012. Pubmed reference: 21922596 . DOI: 10.1002/humu.21611 . |
| 2012 |
Neff,M.W.,Beck,J.S.,Koeman,J.M.,Boguslawski,E.,Kefene,L.,Borgman,A.,Ruhe,A.L.: :
Partial Deletion of the Sulfate Transporter SLC13A1 Is Associated with an Osteochondrodysplasia in the Miniature Poodle Breed. PLoS One 7:e51917, 2012. Pubmed reference: 23300579 . DOI: 10.1371/journal.pone.0051917 . |
| 1999 |
Stevens,J.W.: :
Pseudoachondroplastic dysplasia: an Iowa review from human to mouse. Iowa Orthop J 19:53-65, 1999. Pubmed reference: 10847517 . |
| 1995 |
Johnson KA, Watson ADJ, Page RL. :
Skeletaldiseases W.B. Saunders Co., Toronto. EJ Ettinger and EC Feldman(eds) Textbook of Veterinary InternalMedicine, p. 2087 |
| 1992 |
Breur,G.J.,Farnum,C.E.,Padgett,G.A.,Wilsman,N.J.: :
Cellular basis of decreased rate of longitudinal growth of bone in pseudoachondroplastic dogs. J Bone Joint Surg Am 74:516-28, 1992. Pubmed reference: 1583046 . |
| 1989 |
Breur,G.J.,Zerbe,C.A.,Slocombe,R.F.,Padgett,G.A.,Braden,T.D.: :
Clinical, radiographic, pathologic, and genetic features of osteochondrodysplasia in Scottish deerhounds. J Am Vet Med Assoc 195:606-12, 1989. Pubmed reference: 2777707 . |
| 1980 |
Riser,W.H.,Haskins,M.E.,Jesyk,P.F.,Patterson,D.F.: :
Pseudoachondroplastic dysplasia in Miniature Poodles: : clinical, radiologic, and pathologic features. Journal of the American Veterinary Medical Association 176:335-341, 1980. Pubmed reference: 6987200 . |
| 1977 |
Bruno,W.,Janik,T.: :
What's your diagnosis? Journal of American Veterinary Medical Association 170:1097–1098, 1977. |
| 1966 |
Lodge,D.: :
Two cases of epiphyseal dysplasia. Veterinary Record 79:136–138, 1966. |
| 1961 |
Amlof,J.: :
On achondroplasia in the dog. Zentralblatt fur Veterinaermed 8:43–56, 1961. |
| 1959 |
Gardner,D.: :
Familial canine chondrodysplasia faetalis (achondroplasia). J Pathol Bacterio 77:243-247, 1959. |
| 1956 |
Cotchin,E.,Dyce,K.: :
A case of epiphyseal dsyplasia in a dog. Veterinary Record 68:427–428, 1956. |