Disease Ontology ID: DDTO:0000027
Disease Description: Spinal muscular atrophy (motor neuron disease) causes degeneration and/or death of the motor neurons (motoneurons) in the spinal cord.
Inherit Mode: -
Disease Symptom: -
Disease Cause: -
Disease Diagnose: Diagnosis is based on a thorough neurologic examination, the absence of abnormalities on routine diagnostic tests, and the progressive nature of these conditions. Specific diagnostic tests include muscle biopsy and electronic testing of nerve conduction potentials (an electromyogram) of affected muscles.
Treat Method: There is no treatment. These conditions are slowly or rapidly progressive, with the exception of German shepherd focal spinal muscular atrophy where the effects may be relatively mild.
Breeder Advice: Affected dogs should not be bred. Breeding of parents and siblings (suspect carriers) should be avoided as well, so as not to perpetuate these serious and fortunately rare disorders. In family lines of Brittany spaniels where this disorder has occurred, dogs should not be bred until at least 3 years of age to ensure that any carriers are recognized.
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Motor neuron disease | - | - | - | ||
| Motor neuron disease, lower | - | - | - | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB54 | Brittany | Bright, upbeat, fun-loving at home; a tireless, enthusiastic worker afield | 44.5-52.1 cm | 13.6-18.1 kg | France |
| CB185 | English Pointer | Even-tempered, alert, hardworking, and loyal; a peerless hunting partner | 63.5-71.1 cm (male), 58.4-66 cm (female) | 24.9-34 kg (male), 20.4-29.5 kg (female) | United Kingdom (England) |
| 2002 |
Rich,M.M.,Waldeck,R.F.,Cork,L.C.,Balice-Gordon,R.J.,Fyffe,R.E.W.,Wang,X.Y.,Cope,T.C.,Pinter,M.J.: :
Reduced endplate currents underlie motor unit dysfunction in canine motor neuron disease Journal of Neurophysiology 88:3293-3304, 2002. Pubmed reference: 12466447 . DOI: 10.1152/jn.00270.2002 . |
| 2002 |
Rich,M.M.,Wang,X.Y.,Cope,T.C.,Pinter,M.J.: :
Reduced neuromuscular quantal content with normal synaptic release time course and depression in canine motor neuron disease Journal of Neurophysiology 88:3305-3314, 2002. Pubmed reference: 12466448 . DOI: 10.1152/jn.00271.2002 . |
| 1999 |
Ackerman, L. :
The Genetic Condition: A Guide to Health Problems in Purebred Dogs AAHA Press. Lakewood, Colorado. pp 145-146 |
| 1999 |
Kent,M.,Knowles,K.,Glass,E.,deLahunta,A.,Braund,K.,Alroy,J.: :
Motor neuron abiotrophy in a Saluki Journal of the American Animal Hospital Association 35:436-439, 1999. Pubmed reference: 10493421 . |
| 1998 |
Mandara,M.T.,Di,Meo,A.: :
Lower motor neuron disease in the Griffon Briquet Vendeen dog Veterinary Pathology 35:412-414, 1998. Pubmed reference: 9754548 . |
| 1997 |
Pinter,M.J.,Waldeck,R.F.,Cope,T.C.,Cork,L.C.: :
Effects of 4-AMINOPYRIDINE on muscle and motor unit force in canine motor neuron disease Journal of Neuroscience 17:4500-4507, 1997. Pubmed reference: 9151766 . |
| 1995 |
Cummings, J.F., deLahunta, A. :
Canine neurodegenerative diseases involving motor neurons W.B.Saunders Co., Toronto. J.D. Bonaguara and R.W. Kirk (eds.) Kirk's Current Veterinary Therapy XII Small Animal Practice. pp. 1132-1136 |
| 1992 |
Cork, L.A. :
Canine ventral horn cell disease W.B. Saunders Co., Toronto. J.D. Bonaguara and R.W. Kirk (eds.) Kirk's Current Veterinary Therapy XI Small Animal Practice. pp. 1031-1034 |