Disease Detail Information

Basic Information

Disease Ontology ID: DDTO:0000587

Disease Description: A condition where the roof of the mouth is not closed and the inside of the nose opens into the mouth.

Inherit Mode: In the Brittany Spaniel breed cleft palate is inherited as an autosomal recessive trait.

Disease Symptom: Affected puppies or newborns have difficulty eating and suckling and will not grow as quickly or as large as their littermates. Some pups with cleft palate that attempt to nurse, aspirate and die.

Disease Cause: -

Disease Diagnose: -

Treat Method: It can usually be corrected surgically by a specially trained and skilled veterinarian.

Breeder Advice: -

Disease Description Source: -

Associated Diseases

Disease Name	Other Name	Mode of inheritance	Link ID	Possible OMIM ID	Gene
Cleft palate	-	-			-
Cleft lip and palate	-	Autosomal Recessive		-	-
Cleft palate 1	-	Autosomal Recessive			-
	CIDD	-	-

Associated Breeds

iDog Breed Number	Breed Name	Personality	Height	Weight	Breed Source
CB1	Affenpinshcher(Monkey Terrier)	Loyal, curious, famously funny; fearless out of all proportion to their size	22.9-29.2 cm	3.2-4.5 kg	Germany, France
CB11	American Staffordshire Terrier	Confident, Smart, Good-natured	18-19 inches (male), 17-18 inches (female)	55-70 pounds (male), 40-55 pounds (female)	United States
CB17	Australian Terrier	Affectionate, Courageous, Spirited	25.4-27.9 cm	5.4-8.2 kg	Australia
CB25	Bearded Collie	Bouncy, charismatic, friendly; smart, but also stubborn and independent	53.3-55.9 cm (male), 50.8-53.3 cm (female)	20.4-24.9 kg	United Kingdom (Scotland)
CB35	Bichon Frise	Playful, curious, and peppy	24.1-29.2 cm	5.4-8.2 kg	Spain, Belgium
CB47	Bouvier des Flandres(Flanders Cattle Dog)	Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders	62.2-69.9 cm (male), 59.7-67.3 cm (female)	31.8-49.9 kg	Belgium
CB55	Danish Broholmer	Friendly, Watchful, Loving	27.5-29.5 inches	90-150 pounds	Denmark
CB58	English Bulldog	Calm, courageous, and friendly; dignified but amusing.	35.6-38.1 cm	22.7 kg (male), 18.1 kg (female)	United Kingdom (England)
CB60	Cairn Terrier	Cheerful, alert, busy and independent-minded	25.4 cm (male), 24.1 cm (female)	6.4 kg (male), 5.9 kg (female)	United Kingdom (Scotland)
CB72	Chinese Crested	Lively, alert, and affectionate	27.9-33 cm	3.6-5.4 kg	Africa, Mexico
CB76	Cirneco dell'Etna	Affectionate, Friendly, Independent	18-19.5 inches (male), 16.5-18 inches (female)	22-26 pounds (male), 17-22 pounds (female)	Italy
CB78	Cocker Spaniel	Happy, smart, gentle	36.8-39.4 cm (male), 34.3-36.8 cm (female)	11.3-13.6 kg (male), 9.1-11.3 kg (female)
CB98	English Toy Spaniel	Affectionate, Alert, Merry	22.9-25.4 cm	3.6-6.4 kg	England
CB99	Entlebucher Mountain Dog	Enthusiastic, loyal, smart; confident but not aggressive	43.2-53.3 cm (male), 40.6-50.8 cm (female)	24.9-29.5 kg	Switzerland
CB107	French Spaniel	Friendly, outgoing personality, well balanced and patient,eager to please, can be trained easily			France
CB111	German Short-Haired Pointer	Friendly, smart, willing to please	58.4-63.5 cm (male), 53.3-58.4 cm (female)	24.9-31.8 kg (male), 20.4-27.2 kg (female)	Germany
CB219	Kochi Ken(Shikoku)	Cautious and brave with good judgment,loyal to its master.			Japan

Associated Disease Variants from OMIA

Gene Differential Expression

References

2019	Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: : Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019. Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 .
2017	Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: : Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 .
2017	Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: : Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 .
2014	Davidson,A.P.,Gregory,C.,Dedrick,P.: : Successful Management Permitting Delayed Operative Revision of Cleft Palate in a Labrador Retriever. Vet Clin North Am Small Anim Pract 44:325-329, 2014. Pubmed reference: 24580993 . DOI: 10.1016/j.cvsm.2013.11.002 .
2014	Wolf,Z.T.,Leslie,E.J.,Arzi,B.,Jayashankar,K.,Karmi,N.,Jia,Z.,Rowland,D.J.,Young,A.,Safra,N.,Sliskovic,S.,Murray,J.C.,Wade,C.M.,Bannasch,D.L.: : A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence. PLoS Genet 10:e1004257, 2014. Pubmed reference: 24699068 . DOI: 10.1371/journal.pgen.1004257 .
2009	Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: : Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009. Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 .
2001	Warzee,C.C.,Bellah,J.R.,Richards,D.: : Congenital unilateral cleft of the soft palate in six dogs. J Small Anim Pract 42:338-40, 2001. Pubmed reference: 11480899 .
1997	Elwood,J.M.,Colquhoun,T.A.: : Observations on the prevention of cleft palate in dogs by folic acid and potential relevance to humans New Zealand Veterinary Journal 45:254-256, 1997.
1994	Richtsmeier,J.T.,Sack,G.H.,Grausz,H.M.,Cork,L.C.: : Cleft palate with autosomal recessive transmission in Brittany spaniels Cleft Palate - Craniofacial Journal 31:364-371, 1994. Pubmed reference: 7986797 . DOI: 10.1597/1545-1569(1994)031<0364:CPWART>2.3.CO;2 .
1973	Anon.: : Cleft palate : the elusive anomaly Gaines Dog Research Progress :?, 1973.
1972	Edmonds,L.,Stewart,R.W.,Selby,L.: : Cleft lip and palate in dogs (Boxer breed): a preliminary report Carnivore Genetics Newsletter 9:204-209, 1972.
1971	Cooper,H.K.,Mattern,G.W.: : Genetic studies of cleft lip and palate in dogs. Birth Defects Orig Artic Ser 7:98-100, 1971. Pubmed reference: 5173250 .
1967	Atherton,J.D.: : Cleft palate in the dog. Dent Pract Dent Rec 18:145-50, 1967. Pubmed reference: 5234825 .
1965	Anon.: : Cleft palate in dogs. Dent Stud 44:122, 1965. Pubmed reference: 5214700 .
1965	Bleicher,N.,Sloan,R.F.,Gault,I.G.,Ashley,F.L.: : Cleft palate in a dog. Cleft Palate J 45:56-61, 1965. Pubmed reference: 14232216 .
1961	Calnan,J.: : The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961. Pubmed reference: 13875838 .