The detail information of Craniomandibular osteopathy
Basic Information

Disease Ontology ID: DDTO:0000950

Disease Description: An abnormal development of the bones of the face and the jaw. Seen in West Highland white and Cairn terriers, among other breeds.

Inherit Mode: The mode of inheritance is autosomal recessive in West Highland white terriers. In other breeds, the mode of inheritance has not been determined.

Disease Symptom: Your puppy (3-8 months of age) may have a swollen and painful lower law, or have trouble opening the mouth or eating, or drool excessively. You may not notice all of these problems continuously; the signs may seem to flare up at times then get better. This disease is "self-limiting." After your puppy reaches one year of age, the condition will probably not get worse, and should get better. However if there has been severe bone growth, especially involving the jaw joint, the excess bone may not go away on its own. In some cases, particularly if the jaw joint is not working properly, your dog may need surgery. Your puppy’s condition is more serious and the prognosis is guarded if there is excessive bone growth on the base of the skull.

Disease Cause: -

Disease Diagnose: Your veterinarian will diagnose this disease based on physical examination, history, and x-rays.

Treat Method: There is no treatment to stop the disease from getting worse; it will usually get better as your puppy grows up. Pain can be treated with anti-inflammatory drugs. Your puppy may need surgery in certain severe cases. For the veterinarian:Bony proliferation is usually bilateral. Clinical signs of this disease (including swollen mandible which may be painful, and difficulty or pain opening the mouth), may be intermittent, and may be associated with pyrexia. Radiographs may show involvement of bones of the skull other than the mandible and temporomandibular region. In some cases, bone biopsy and histopathology may be helpful in differentiating this disease from other conditions involving excess bone growth. This disease is self-limiting, and excess bone should not proliferate beyond one year of age. Excess bone may not completely regress. Pain may be managed with anti-inflammatory drugs.

Breeder Advice: Affected dogs should not be used for breeding, even if they appear to recover completely. Breeding of parents (carriers) and siblings (suspect carriers) should also be avoided. The Institute for Genetic Disease Control in Animals (GDC) and the Orthopedic Foundation for Animals (OFA) maintain registries for this condition in terrier breeds.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Craniomandibular osteopathy, generic - Multifactorial -
Craniomandibular osteopathy, SLC37A2-related - Autosomal dominant with incomplete penetrance -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB46 Boston Terrier Friendly, bright, amusing, and adaptable. 38.1-43.2 cm 4.5-11.3 kg United States
CB60 Cairn Terrier Cheerful, alert, busy and independent-minded 25.4 cm (male), 24.1 cm (female) 6.4 kg (male), 5.9 kg (female) United Kingdom (Scotland)
CB214 Scottish Terrier Independent, confident, and never shy; spirited but dignified 25.4 cm 8.6-10 kg (male), 8.2-9.5 kg (female) United Kingdom (Scotland)
CB255 West Highland White Terrier Happy, smart, loyal, entertaining 27.9 cm (male). 25.4 cm, female 6.8-9.1 kg United Kingdom (Scotland)
CB45 Borzoi(Russian wolfhound) Loyal, affectionate, regally dignified; a charming but independent-minded canine nobleman 71.1 cm & up (male), 66 cm & up (female) 34-47.6 kg (male), 27.2-38.6 kg (female) Russia
CB47 Bouvier des Flandres(Flanders Cattle Dog) Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders 62.2-69.9 cm (male), 59.7-67.3 cm (female) 31.8-49.9 kg Belgium
CB61 Canaan Dog Alert, vigilant, territorial; docile with family, aloof with strangers 50.8-61 cm (male), 48.3-58.4 cm (female) 20.4-24.9 kg (male), 15.9-20.4 kg (female) Middle East Lebanon - Israel
CB89 Dogo Argentino Loyal, trustworthy,courageous 61-68.6 cm (male), 59.7-66 cm (female) 36.3-45.4 kg Argentina
CB97 English Springer Spaniel Friendly, playful, obedient at home; hardworking and steady in the field 50.8 cm (male), 48.3 cm (female) 22.7 kg (male), 18.1 kg (female) United Kingdom (England)
CB148 Lagotto Romagnolo(Romagna Water Dog) Easygoing, affectionate, and eager to please 43.2-48.3 cm (male), 40.6-45.7 cm (female) 12.9-15.9 kg (male), 10.9-14.1 kg (female) Italy
CB215 Sealyham Terrier Alert and outgoing; stubbornness is tempered by a sly sense of humor 26.7 cm 10.4-10.9 kg (male), slightly less (females) United Kingdom (Wales)
CB252 Weimaraner Friendly, fearless, alert, obedient 63.5-68.6 cm (male), 58.4-63.5 cm (female) 31.8-40.8 kg (male), 24.9-34 kg (female) Germany
CB256 English Whippet Calm, affectionate, and playful 48.3-55.9 cm (male), 45.7-53.3 cm (female) 11.3-18.1 kg England
Associated Disease Variants from OMIA
Gene Differential Expression
References
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