The detail information of Atopic dermatitis
Basic Information

Disease Ontology ID: DDTO:0000622

Disease Description: Inflammation and subsequent infection of the skin due to atopy

Inherit Mode: -

Disease Symptom: Many dogs with chronic allergy develop pink, red, bronze or dark skin. The bronzing color is from pigment in the dog's saliva that discolors the skin and the hair. Foot licking, recurrent ear inflammation, face rubbing, itching of the armpits and groin in a young animal is very suggestive of atopy.

Disease Cause: -

Disease Diagnose: Diagnosis of allergies is a complicated task and usually involves various tests, such as skin scrapings, fungal cultures, and blood tests. However, the investigation of a suspected allergic dog includes rigorous treatment for external parasites and secondary bacterial and yeast infections, which often complicate and contribute to the itch. A diagnosis of food intolerance is made in 2-10% of dog with intense itch. Food allergies can be controlled without using drugs and are worth ruling out by introducing an elimination diet followed by dietary challenge to confirm the diagnosis. Elimination diets are time consuming and require considerable owner commitment. It can be up to 3 months before the dog stops scratching. Once other causes of itch have been ruled out, specific tests to detect allergic antibodies to environmental allergens can be undertaken to confirm the diagnosis of atopy.

Treat Method: Conventional therapy for atopic dermatitis relies on corticosteroids and antihistamines. Corticosteroids can be given by injection, by mouth, or by both routes. The most commonly used corticosteroids are prednisone, prednisolone, dexamethasone, and triamcinolone. While very effective when used to control itching and inflammation, corticosteroids have both short-term and long-term side effects. Short-term side effects include increased water intake, increased urination, increased appetite, and destruction of joint cartilage. Long-term side effects are numerous and include suppression of the immune system, infections, diabetes, liver disease, joint problems, obesity, glaucoma, cataracts, high blood pressure and stomach ulcers. When needed, short-term use of fast-acting corticosteroids is preferred. Depot injections are not usually recommended for dogs, but are commonly used in cats.For the above reasons, holistic doctors prefer not using steroids for long periods of time unless it is absolutely necessary. In pets with allergy, antioxidants, fatty acids, hypoallergenic shampoos and conditioners and herbal remedies can decrease itching and inflammation. Principal natural treatments include topical decontamination with frequent hypoallergenic shampooing and conditioning, omega-3 fatty acids, and natural diet.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Dermatitis, atopic Canine atopic dermatitis (CAD) - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB25 Bearded Collie Bouncy, charismatic, friendly; smart, but also stubborn and independent 53.3-55.9 cm (male), 50.8-53.3 cm (female) 20.4-24.9 kg United Kingdom (Scotland)
CB49 Boykin Spaniel Friendly, eager, trainable, lovable 39.4-45.7 cm (male), 35.6-41.9 cm (female) 13.6-18.1 kg (male), 11.3-15.9 kg (female) United States
CB85 Dandie Dinmont Terrier Independent, proud, smart; affectionate at home, bold and tenacious in the field 20.3-27.9 cm 8.2-10.9 kg United Kingdom (Scotland)
CB111 German Short-Haired Pointer Friendly, smart, willing to please 58.4-63.5 cm (male), 53.3-58.4 cm (female) 24.9-31.8 kg (male), 20.4-27.2 kg (female) Germany
CB117 Gordon Setter Bold, confident, and resolute afield; sweetly affectionate by the fireside 61-68.6 cm (male), 58.4-66 cm (female) 24.9-36.3 kg (male), 20.4-31.8 kg (female) United Kingdom (Scotland)
CB132 Irish Terrier Bold, dashing, even reckless; stouthearted at work, tenderhearted at home 45.7 cm 12.2 kg (male), 11.3 kg (female) Ireland
CB148 Lagotto Romagnolo(Romagna Water Dog) Easygoing, affectionate, and eager to please 43.2-48.3 cm (male), 40.6-45.7 cm (female) 12.9-15.9 kg (male), 10.9-14.1 kg (female) Italy
CB154 Lowchen(Little Lion Dog) Affectionate, Outgoing, Positive 12-14 inches 15 pounds Germany, France, Netherlands, Spain
CB197 Hungarian Puli Loyal, smart, home-loving; strong-willed but trainable 43.2 cm (male), 40.6 cm (female) 11.3-15.9 kg Hungary
CB215 Sealyham Terrier Alert and outgoing; stubbornness is tempered by a sly sense of humor 26.7 cm 10.4-10.9 kg (male), slightly less (females) United Kingdom (Wales)
CB216 Shetland Shepherd Dog Bright, playful, and energetic 33-40.6 cm 6.8-11.3 kg United Kingdom (Scotland)
CB228 Soft-Coated Wheaten Terrier Happy, friendly, and deeply devoted; just stubborn enough to remind you they’re terriers 45.7-48.3 cm (male), 43.2-45.7 cm (female) 15.9-18.1 kg (male), 13.6-15.9 kg (female) Ireland
CB229 Spanish Mastiff Aloof, dignified, calm and intelligent Spain
CB256 English Whippet Calm, affectionate, and playful 48.3-55.9 cm (male), 45.7-53.3 cm (female) 11.3-18.1 kg England
CB268 Miniature Poodle Intelligent, Eager-to-please , Charming companion 25-38 cm 4.5-6.8kg France&Germany
CB269 Standard Poodle Intelligent and quick-to-please 56-66 cm
CB270 Toy Poodle Intelligent, eager to please, quick to learn and an affectionate, loyal pet. under 25 cm
Associated Disease Variants from OMIA
Gene Differential Expression
References
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2019 Agler,C.S.,Friedenberg,S.,Olivry,T.,Meurs,K.M.,Olby,N.J.: :
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2019 Harvey,N.D.,Shaw,S.C.,Craigon,P.J.,Blott,S.C.,England,G.C.W.: :
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2017 Martel,B.C.,Lovato,P.,Bäumer,W.,Olivry,T.: :
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2016 Asahina,R.,Maeda,S.: :
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2016 Bruet,V.,Dumon,H.,Bourdeau,P.,Desfontis,J.C.,Martin,L.: :
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2016 Hauck,V.,Hügli,P.,Meli,M.L.,Rostaher,A.,Fischer,N.,Hofmann-Lehmann,R.,Favrot,C.: :
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2016 Kim,H.J.,Cronin,M.,Ahrens,K.,Papastavros,V.,Santoro,D.,Marsella,R.: :
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2016 Majewska,A.,Gajewska,M.,Dembele,K.,Maciejewski,H.,Prostek,A.,Jank,M.: :
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2016 Mazrier,H.,Vogelnest,L.J.,Thomson,P.C.,Taylor,R.M.,Williamson,P.: :
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2016 Pierezan,F.,Olivry,T.,Paps,J.S.,Lawhon,S.D.,Wu,J.,Steiner,J.M.,Suchodolski,J.S.,RodriguesHoffmann,A.: :
The skin microbiome in allergen-induced canine atopic dermatitis. Vet Dermatol :, 2016.
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2016 Sakamoto,M.,Asahina,R.,Kamishina,H.,Maeda,S.: :
Transcription of thymic stromal lymphopoietin via Toll-like receptor 2 in canine keratinocytes: a possible association of Staphylococcus spp. in the deterioration of allergic inflammation in canine atopic dermatitis. Vet Dermatol :, 2016.
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2016 Saridomichelakis,M.N.,Olivry,T.: :
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2016 Tengvall,K.,Kozyrev,S.,Kierczak,M.,Bergvall,K.,Farias,F.H.,Ardesjö-Lundgren,B.,Olsson,M.,Murén,E.,Hagman,R.,Leeb,T.,Pielberg,G.,Hedhammar,Å.,Andersson,G.,Lindblad-Toh,K.: :
Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs. BMC Genet 17:97, 2016.
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2015 Bizikova,P.,Pucheu-Haston,C.M.,Eisenschenk,M.N.,Marsella,R.,Nuttall,T.,Santoro,D.: :
Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis. Vet Dermatol :, 2015.
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2015 Bizikova,P.,Santoro,D.,Marsella,R.,Nuttall,T.,Eisenschenk,M.N.,Pucheu-Haston,C.M.: :
Review: Clinical and histological manifestations of canine atopic dermatitis. Vet Dermatol :, 2015.
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2015 Hensel,P.,Santoro,D.,Favrot,C.,Hill,P.,Griffin,C.: :
Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification. BMC Vet Res 11:196, 2015.
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2015 LeRoy,L.,LePoder,S.,Desquilbet,L.,Perrot,S.,Cavana,P.,Marignac,G.: :
Canine Atopic Dermatitis Diagnostic Criteria: Evaluation of Four Sets of Published Criteria among Veterinary Students. J Vet Med Educ 42:79-84, 2015.
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2015 Mineshige,T.,Kamiie,J.,Sugahara,G.,Yasuno,K.,Aihara,N.,Kawarai,S.,Yamagishi,K.,Shirota,M.,Shirota,K.: :
Expression of Periostin in Normal, Atopic, and Nonatopic Chronically Inflamed Canine Skin. Vet Pathol :, 2015.
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2015 Müller,M.R.,Linek,M.,Löwenstein,C.,Röthig,A.,Doucette,K.,Thorstensen,K.,Mueller,R.S.: :
Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis. Vet J :, 2015.
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2015 Pucheu-Haston,C.M.,Bizikova,P.,Eisenschenk,M.N.,Santoro,D.,Nuttall,T.,Marsella,R.: :
Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis. Vet Dermatol :, 2015.
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2015 Pucheu-Haston,C.M.,Bizikova,P.,Marsella,R.,Santoro,D.,Nuttall,T.,Eisenschenk,M.N.: :
Review: Lymphocytes, cytokines, chemokines and the T-helper 1-T-helper 2 balance in canine atopic dermatitis. Vet Dermatol 26:124-e32, 2015.
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2015 Pucheu-Haston,C.M.,Eisenschenk,M.N.,Bizikova,P.,Marsella,R.,Nuttall,T.,Santoro,D.: :
Introduction to the review articles by ICADA on the pathogenesis of atopic dermatitis in dogs. Vet Dermatol 26:77-8, 2015.
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2015 Pucheu-Haston,C.M.,Santoro,D.,Bizikova,P.,Eisenschenk,M.N.,Marsella,R.,Nuttall,T.: :
Review: Innate immunity, lipid metabolism and nutrition in canine atopic dermatitis. Vet Dermatol :, 2015.
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2015 Santoro,D.,Marsella,R.,Pucheu-Haston,C.M.,Eisenschenk,M.N.,Nuttall,T.,Bizikova,P.: :
Review: Pathogenesis of canine atopic dermatitis: skin barrier and host-micro-organism interaction. Vet Dermatol :, 2015.
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2014 Bruet,V.,Lieubeau,B.,Herve,J.,Roussel,A.,Imparato,L.,Desfontis,J.,Bourdeau,P.: :
Increased numbers of peripheral blood CD34+ cells in dogs with canine atopic dermatitis. Vet Dermatol :, 2014.
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2014 Litzlbauer,P.,Weber,K.,Mueller,R.S.: :
Oral and subcutaneous therapy of canine atopic dermatitis with recombinant feline interferon omega. Cytokine 66:54-9, 2014.
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2014 Olivry,T.,Saridomichelakis,M.,Nuttall,T.,Bensignor,E.,Griffin,C.E.,Hill,P.B.: :
Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol :, 2014.
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2014 Schumann,J.,Basiouni,S.,Gück,T.,Fuhrmann,H.: :
Treating canine atopic dermatitis with unsaturated fatty acids: the role of mast cells and potential mechanisms of action. J Anim Physiol Anim Nutr (Berl) :, 2014.
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2013 Dip,R.,Carmichael,J.,Letellier,I.,Strehlau,G.,Roberts,E.,Bensignor,E.,Rosenkrantz,W.: :
Concurrent short-term use of prednisolone with cyclosporine A accelerates pruritus reduction and improvement in clinical scoring in dogs with atopic dermatitis. BMC Vet Res 9:173, 2013.
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2013 Fernández-Caldas,E.: :
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2013 Jassies-vanderLee,A.,Rutten,V.,Spiering,R.,vanKooten,P.,Willemse,T.,Broere,F.: :
The immunostimulatory effect of CpG oligodeoxynucleotides on peripheral blood mononuclear cells of healthy dogs and dogs with atopic dermatitis. Vet J :, 2013.
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2013 Jung,J.Y.,Nam,E.H.,Park,S.H.,Han,S.H.,Hwang,C.Y.: :
Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis. J Vet Sci 14:199-205, 2013.
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2013 Koike,A.,Kano,R.,Nagata,M.,Chen,C.,Hwang,C.Y.,Hasegawa,A.,Kamata,H.: :
Genotyping of Malassezia pachydermatis Isolates from Canine Healthy Skin and Lesional Skin of Atopic Dermatitis in Japan, Korea and Taiwan. J Vet Med Sci :, 2013.
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2013 Lancto,C.A.,Torres,S.M.,Hendrickson,J.A.,Martins,K.V.,Rutherford,M.S.: :
Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions. Vet Dermatol :, 2013.
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2013 Nuttall,T.: :
The genomics revolution: will canine atopic dermatitis be predictable and preventable? Vet Dermatol 24:10-8.e3-4, 2013.
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2013 Nuttall,T.,Uri,M.,Halliwell,R.: :
Canine atopic dermatitis - what have we learned? Vet Rec 172:201-7, 2013.
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2013 Ognjenovic,J.,Milcic-Matic,N.,Smiljanic,K.,Vuckovic,O.,Burazer,L.,Popovic,N.,Stanic-Vucinic,D.,Velickovic,T.C.: :
Immunoproteomic characterization of Ambrosia artemisiifolia pollen allergens in canine atopic dermatitis. Vet Immunol Immunopathol 155:38-47, 2013.
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2013 Pellicoro,C.,Marsella,R.,Ahrens,K.: :
Pilot study to evaluate the effect of topical dimethicone on clinical signs and skin barrier function in dogs with naturally occurring atopic dermatitis. Vet Med Int 2013:239186, 2013.
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2013 Prélaud,A.R.,Fuchs,S.,Weber,K.,Winter,G.,Coester,C.,Mueller,R.S.: :
In vitro effects of CpG oligodeoxynucleotides delivered by gelatin nanoparticles on canine peripheral blood mononuclear cells of atopic and healthy dogs - a pilot study. Vet Dermatol :, 2013.
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2013 Puigdemont,A.,Brazís,P.,Ordeix,L.,Dalmau,A.,Fuertes,E.,Olivar,A.,Pérez,C.,Ravera,I.: :
Efficacy of a new topical cyclosporine A formulation in the treatment of atopic dermatitis in dogs. Vet J :, 2013.
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2013 Santoro,D.,Marsella,R.,Ahrens,K.,Graves,T.K.,Bunick,D.: :
Altered mRNA and protein expression of filaggrin in the skin of a canine animal model for atopic dermatitis. Vet Dermatol 24:329-36, e73, 2013.
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2013 Tengvall,K.,Kierczak,M.,Bergvall,K.,Olsson,M.,Frankowiack,M.,Farias,F.H.,Pielberg,G.,Carlborg,O.,Leeb,T.,Andersson,G.,Hammarström,L.,Hedhammar,A.,Lindblad-Toh,K.: :
Correction: Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic Dermatitis. PLoS Genet 9:, 2013.
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2013 Tengvall,K.,Kierczak,M.,Bergvall,K.,Olsson,M.,Frankowiack,M.,Farias,F.H.,Pielberg,G.,Carlborg,Ö.,Leeb,T.,Andersson,G.,Hammarström,L.,Hedhammar,Å.,Lindblad-Toh,K.: :
Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitis. PLoS Genet 9:e1003475, 2013.
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2012 Campora,L.,Miragliotta,V.,Ricci,E.,Cristino,L.,DiMarzo,V.,Albanese,F.,FedericaDellaValle,M.,Abramo,F.: :
Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis. Am J Vet Res 73:988-95, 2012.
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2012 Kovalik,M.,Thoday,K.L.,Evans,H.,Berry,J.,vandenBroek,A.H.,Mellanby,R.J.: :
Short-term prednisolone therapy has minimal impact on calcium metabolism in dogs with atopic dermatitis. Vet J :, 2012.
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2012 Lauber,B.,Molitor,V.,Meury,S.,Doherr,M.G.,Favrot,C.,Tengvall,K.,Bergvall,K.,Leeb,T.,Roosje,P.,Marti,E.: :
Total IgE and allergen-specific IgE and IgG antibody levels in sera of atopic dermatitis affected and non-affected Labrador- and Golden retrievers. Vet Immunol Immunopathol 149:112-8, 2012.
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2012 Marsella,R.,Sousa,C.A.,Gonzales,A.J.,Fadok,V.A.: :
Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc 241:194-207, 2012.
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2012 Olivry,T.: :
What can dogs bring to atopic dermatitis research? Chem Immunol Allergy 96:61-72, 2012.
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2012 Plager,D.A.,Torres,S.M.,Koch,S.N.,Kita,H.: :
Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases. Vet Immunol Immunopathol 149:136-42, 2012.
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2012 Plant,J.D.,Gortel,K.,Kovalik,M.,Polissar,N.L.,Neradilek,M.B.: :
Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis. Vet Dermatol 23:515-e103, 2012.
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2012 Roque,J.B.,O'Leary,C.A.,Duffy,D.L.,Kyaw-Tanner,M.,Gharahkhani,P.,Vogelnest,L.,Mason,K.,Shipstone,M.,Latter,M.: :
Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17. Immunogenetics 64:209-17, 2012.
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2012 Theerawatanasirikul,S.,Sailasuta,A.,Thanawongnuwech,R.,Suriyaphol,G.: :
Alterations of keratins, involucrin and filaggrin gene expression in canine atopic dermatitis. Res Vet Sci 93:1287-92, 2012.
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2011 Kovalik,M.,Thoday,KL.,Evans,H.,vandenBroek,AH.,Mellanby,RJ.: :
Prednisolone is associated with an increase in serum insulin but not serum fructosamine concentrations in dogs with atopic dermatitis. Vet J :, 2011.
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2011 Marsella,R.,Olivry,T.,Carlotti,D.N.: :
Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Vet Dermatol 22:239-48, 2011.
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2011 Meury,S.,Molitor,V.,Doherr,M.G.,Roosje,P.,Leeb,T.,Hobi,S.,Wilhelm,S.,Favrot,C.: :
Role of the environment in the development of canine atopic dermatitis in Labrador and golden retrievers. Vet Dermatol 22:327-34, 2011.
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2011 Olivry,T.: :
Is the skin barrier abnormal in dogs with atopic dermatitis? Vet Immunol Immunopathol :, 2011.
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2011 Roque,J.B.,O'Leary,C.A.,Kyaw-Tanner,M.,Duffy,D.L.,Gharahkhani,P.,Vogelnest,L.,Mason,K.,Shipstone,M.: :
PTPN22 polymorphisms may indicate a role for this gene in atopic dermatitis in West Highland white terriers. BMC Res Notes 4:571, 2011.
Pubmed reference: 22208456 . DOI: 10.1186/1756-0500-4-571 .
2011 Salzmann,C.A.,Olivry,T.J.,Nielsen,D.M.,Paps,J.S.,Harris,T.L.,Olby,N.J.: :
Genome-wide linkage study of atopic dermatitis in West Highland White Terriers. BMC Genet 12:37, 2011.
Pubmed reference: 21510878 . DOI: 10.1186/1471-2156-12-37 .
2010 Chervet,L.,Galichet,A.,McLean,W.H.,Chen,H.,Suter,M.M.,Roosje,P.J.,Müller,E.J.: :
Missing C-terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis. Exp Dermatol 19:e343-6, 2010.
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2010 Favrot,C.,Steffan,J.,Seewald,W.,Picco,F.: :
A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol 21:23-31, 2010.
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2010 Jaeger,K.,Linek,M.,Power,H.T.,Bettenay,S.V.,Zabel,S.,Rosychuk,R.A.,Mueller,R.S.: :
Breed and site predispositions of dogs with atopic dermatitis: a comparison of five locations in three continents. Vet Dermatol 21:118-22, 2010.
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2010 Marsella,R.: :
Canine atopic dermatitis: what's new? Compend Contin Educ Vet 32:E1-4, 2010.
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2010 Olivry,T.: :
New diagnostic criteria for canine atopic dermatitis. Vet Dermatol 21:123-6, 2010.
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2010 Olivry,T.,Foster,AP.,Mueller,RS.,McEwan,NA.,Chesney,C.,Williams,HC.: :
Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials. Vet Dermatol 21:4-22, 2010.
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2009 Marsella,R.,Girolomoni,G.: :
Canine models of atopic dermatitis: a useful tool with untapped potential. J Invest Dermatol 129:2351-7, 2009.
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2009 Marsella,R.,Samuelson,D.: :
Unravelling the skin barrier: a new paradigm for atopic dermatitis and house dust mites. Vet Dermatol 20:533-40, 2009.
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2009 Wood,S.H.,Clements,D.N.,Ollier,W.E.,Nuttall,T.,McEwan,N.A.,Carter,S.D.: :
Gene expression in canine atopic dermatitis and correlation with clinical severity scores. J Dermatol Sci 55:27-33, 2009.
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2009 Wood,S.H.,Ke,X.,Nuttall,T.,McEwan,N.,Ollier,W.E.,Carter,S.D.: :
Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs. Immunogenetics 61:765-72, 2009.
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2008 Keppel,KE.,Campbell,KL.,Zuckermann,FA.,Greeley,EA.,Schaeffer,DJ.,Husmann,RJ.: :
Quantitation of canine regulatory T cell populations, serum interleukin-10 and allergen-specific IgE concentrations in healthy control dogs and canine atopic dermatitis patients receiving allergen-specific immunotherapy. Vet Immunol Immunopathol 123:337-44, 2008.
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2007 Nødtvedt,A.,Guitian,J.,Egenvall,A.,Emanuelson,U.,Pfeiffer,D.U.: :
The spatial distribution of atopic dermatitis cases in a population of insured Swedish dogs. Prev Vet Med 78:210-22, 2007.
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2006 Breathnach,R.,Donahy,C.,Jones,B.R.,Bloomfield,F.J.: :
Increased leukotriene B(4) production, complement C3 conversion and acid hydrolase enzyme concentrations in different leucocyte sub-populations of dogs with atopic dermatitis. Vet J 171:106-13, 2006.
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2006 Nødtvedt,A.,Egenvall,A.,Bergvall,K.,Hedhammar,A.: :
Incidence of and risk factors for atopic dermatitis in a Swedish population of insured dogs. Vet Rec 159:241-6, 2006.
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2006 Steffan,J.,Favrot,C.,Mueller,R.: :
A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Vet Dermatol 17:3-16, 2006.
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2006 Tarpataki,N.: :
Recent developments in canine atopic dermatitis: a review. Acta Vet Hung 54:473-84, 2006.
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2005 Colombo,S.,Hill,PB.,Shaw,DJ.,Thoday,KL.: :
Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study. Vet Dermatol 16:162-70, 2005.
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2005 Hou,CC.,Pemberton,A.,Nuttall,T.,Hill,PB.: :
IgG responses to antigens from Dermatophagoides farinae in healthy and atopic dogs. Vet Immunol Immunopathol 106:121-8, 2005.
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2005 Maeda,S.,Tsukui,T.,Saze,K.,Masuda,K.,Ohno,K.,Tsujimoto,H.,Iwabuchi,S.: :
Production of a monoclonal antibody to canine thymus and activation-regulated chemokine (TARC) and detection of TARC in lesional skin from dogs with atopic dermatitis. Vet Immunol Immunopathol 103:83-92, 2005.
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2005 McEwan,NA.,Kalna,G.,Mellor,D.: :
A comparison of adherence by four strains of Staphylococcus intermedius and Staphylococcus hominis to canine corneocytes collected from normal dogs and dogs suffering from atopic dermatitis. Res Vet Sci 78:193-8, 2005.
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2005 Mueller,R.S.,Fieseler,K.V.,Rosychuk,R.A.,Greenwalt,T.: :
Intradermal testing with the storage mite Tyrophagus putrescentiae in normal dogs and dogs with atopic dermatitis in Colorado. Vet Dermatol 16:27-31, 2005.
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2005 Mueller,RS.,Fettman,MJ.,Richardson,K.,Hansen,RA.,Miller,A.,Magowitz,J.,Ogilvie,GK.: :
Plasma and skin concentrations of polyunsaturated fatty acids before and after supplementation with n-3 fatty acids in dogs with atopic dermatitis. Am J Vet Res 66:868-73, 2005.
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2005 Steffan,J.,Parks,C.,Seewald,W.: :
Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitis. J Am Vet Med Assoc 226:1855-63, 2005.
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2004 Marsella,R.,Nicklin,CF.,Saglio,S.,Lopez,J.: :
Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic) in canine atopic dermatitis: a randomized, double-blinded, placebo-controlled, cross-over study. Vet Dermatol 15:294-303, 2004.
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2004 Mueller,R.S.,Chapman,P.L.: :
Cross reactivity of airborne allergens based on 1000 intradermal test results. Aust Vet J 82:351-4, 2004.
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2004 Mueller,R.S.,Fieseler,K.V.,Fettman,M.J.,Zabel,S.,Rosychuk,R.A.,Ogilvie,G.K.,Greenwalt,T.L.: :
Effect of omega-3 fatty acids on canine atopic dermatitis. J Small Anim Pract 45:293-7, 2004.
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2004 Shaw,SC.,Wood,JL.,Freeman,J.,Littlewood,JD.,Hannant,D.: :
Estimation of heritability of atopic dermatitis in Labrador and Golden Retrievers. Am J Vet Res 65:1014-20, 2004.
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2004 Shida,M.,Kadoya,M.,Park,SJ.,Nishifuji,K.,Momoi,Y.,Iwasaki,T.: :
Allergen-specific immunotherapy induces Th1 shift in dogs with atopic dermatitis. Vet Immunol Immunopathol 102:19-31, 2004.
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2003 Arlian,L.G.,Schumann,R.J.,Morgan,M.S.,Glass,R.L.: :
Serum immunoglobulin E against storage mite allergens in dogs with atopic dermatitis American Journal of Veterinary Research 64:32-36, 2003.
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2003 Graham,L.F.,Torres,S.M.,Jessen,C.R.,Horne,K.L.,Hendrix,P.K.: :
Effects of propofol-induced sedation on intradermal test reactions in dogs with atopic dermatitis Veterinary Dermatology 14:167-76, 2003.
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2003 Olivry,T.,Mueller,R.S.,TheInternationalTaskForceonCanineAtopicDerm: :
Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis.[comment] Veterinary Dermatology 14:121-46, 2003.
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2002 Egli,K.S.,Schiessl,B.,Roosje,P.J.,Seewald,W.L.,Forster,U.,Peel,J.E.,Welle,M.M.: :
Evaluation of the usefulness of sensitization to aeroallergens as a model for canine atopic dermatitis in genetically predisposed Beagles American Journal of Veterinary Research 63:1329-1336, 2002.
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2002 Hillier,A.: :
Allergy testing and treatment for canine atopic dermatitis Veterinary Medicine 97:210-+, 2002.
2002 Hillier,A.: :
Definitively diagnosing atopic dermatitis in dogs Veterinary Medicine 97:198-+, 2002.
2002 Hillier,A.: :
Symposium on atopic dermatitis Veterinary Medicine 97:196, 2002.
2002 Jackson,H.A.,Orton,S.M.,Hammerberg,B.: :
IgE is present on peripheral blood monocytes and B cells in normal dogs and dogs with atopic dermatitis but there is no correlation with serum IgE concentrations Veterinary Immunology & Immunopathology 85:225-232, 2002.
2002 Jouppi,R.: :
Response to the letters regarding the treatment of canine atopic dermatitis with a homeopathic remedy Canadian Veterinary Journal - Revue Veterinaire Canadienne 43:910-911, 2002.
2002 Maeda,S.,Fujiwara,S.,Omori,K.,Kawano,K.,Kurata,K.,Masuda,K.,Ohno,K.,Tsujimoto,H.: :
Lesional expression of thymus and activation-regulated chemokine in canine atopic dermatitis Veterinary Immunology & Immunopathology 88:79-87, 2002.
2002 Mueller,R.S.,Chapman,P.L.,Rosychuk,R.E.W.,Bettenay,S.V.,Fieseler,K.V.: :
Evaluation of cross-reactivity of allergens by use of intradermal testing in atopic dogs American Journal of Veterinary Research 63:874-879, 2002.
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2002 Nuttall,T.J.,Knight,P.A.,McAleese,S.M.,Lamb,J.R.,Hill,P.B.: :
T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis Veterinary Immunology & Immunopathology 87:379-384, 2002.
2002 Nuttall,T.J.,Knight,P.A.,McAleese,S.M.,Lamb,J.R.,Hill,P.B.: :
Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis Clinical & Experimental Allergy 32:789-795, 2002.
2002 Nuttall,T.J.,Pemberton,A.D.,Lamb,J.R.,Hill,P.B.: :
Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis Veterinary Immunology & Immunopathology 84:143-150, 2002.
2002 Olivry,T.,Rivierre,C.,Jackson,H.A.,Murphy,K.M.,Davidson,G.,Sousa,C.A.: :
Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial Veterinary Dermatology 13:77-87, 2002.
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2002 Scott,D.W.,Miller,W.H.,Senter,D.A.,Cook,C.P.,Kirker,J.E.,Cobb,S.M.: :
Treatment of canine atopic dermatitis with a commercial homeopathic remedy: A single-blinded, placebo-controlled study Canadian Veterinary Journal - Revue Veterinaire Canadienne 43:601-603, 2002.
2002 Sinke,J.D.,Rutten,V.P.M.G.,Willemse,T.: :
Immune dysregulation in atopic dermatitis Veterinary Immunology & Immunopathology 87:351-356, 2002.
2002 Yamashita,K.,Fujiwara,C.,Azuma,R.,Sawazaki,T.,Nakao,Y.,Hasegawa,A.: :
Determination of antigenic proteins of Housedust mites in 90 dogs suffering from atopic dermatitis Journal of Veterinary Medical Science 64:673-676, 2002.
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2002 Zur,G.,Ihrke,P.J.,White,S.D.,Kass,P.H.: :
Canine atopic dermatitis: a retrospective study of 266 cases examined at the University of California, Davis, 1992-1998. Part I. Clinical features and allergy testing results Veterinary Dermatology 13:89-102, 2002.
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2002 Zur,G.,White,S.D.,Ihrke,P.J.,Kass,P.H.,Toebe,N.: :
Canine atopic dermatitis: a retrospective study of 169 cases examined at the University of California, Davis, 1992-1998. Part II. Response to hyposensitization Veterinary Dermatology 13:103-111, 2002.
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2001 DeBoer,D.J.,Griffin,C.E.: :
The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy. Vet Immunol Immunopathol 81:323-9, 2001.
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2001 DeBoer,D.J.,Hillier,A.: :
The ACVD task force on canine atopic dermatitis (XVI): laboratory evaluation of dogs with atopic dermatitis with serum-based "allergy" tests. Vet Immunol Immunopathol 81:277-87, 2001.
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2001 DeBoer,D.J.,Hillier,A.: :
The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet Immunol Immunopathol 81:271-6, 2001.
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2001 DeBoer,D.J.,Marsella,R.: :
The ACVD task force on canine atopic dermatitis (XII): the relationship of cutaneous infections to the pathogenesis and clinical course of canine atopic dermatitis. Vet Immunol Immunopathol 81:239-49, 2001.
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2001 Griffin,C.E.,DeBoer,D.J.: :
The ACVD task force on canine atopic dermatitis (XIV): clinical manifestations of canine atopic dermatitis. Vet Immunol Immunopathol 81:255-69, 2001.
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2001 Griffin,C.E.,Hillier,A.: :
The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy. Vet Immunol Immunopathol 81:363-83, 2001.
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2001 Halliwell,R.E.,DeBoer,D.J.: :
The ACVD task force on canine atopic dermatitis (III): the role of antibodies in canine atopic dermatitis. Vet Immunol Immunopathol 81:159-67, 2001.
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2001 Hill,P.B.,DeBoer,D.J.: :
The ACVD task force on canine atopic dermatitis (IV): environmental allergens. Vet Immunol Immunopathol 81:169-86, 2001.
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2001 Hill,P.B.,Hillier,A.,Olivry,T.: :
The ACVD task force on canine atopic dermatitis (VI): IgE-induced immediate and late-phase reactions, two inflammatory sequences at sites of intradermal allergen injections. Vet Immunol Immunopathol 81:199-204, 2001.
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2001 Hill,P.B.,Olivry,T.: :
The ACVD task force on canine atopic dermatitis (V): biology and role of inflammatory cells in cutaneous allergic reactions. Vet Immunol Immunopathol 81:187-98, 2001.
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2001 Hillier,A.,DeBoer,D.J.: :
The ACVD task force on canine atopic dermatitis (XVII): intradermal testing. Vet Immunol Immunopathol 81:289-304, 2001.
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2001 Hillier,A.,Griffin,C.E.: :
The ACVD task force on canine atopic dermatitis (I): incidence and prevalence. Vet Immunol Immunopathol 81:147-51, 2001.
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2001 Hillier,A.,Griffin,C.E.: :
The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions? Vet Immunol Immunopathol 81:227-31, 2001.
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2001 Marsella,R.,Olivry,T.: :
The ACVD task force on canine atopic dermatitis (VII): mediators of cutaneous inflammation. Vet Immunol Immunopathol 81:205-13, 2001.
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2001 Marsella,R.,Olivry,T.: :
The ACVD task force on canine atopic dermatitis (XXII): nonsteroidal anti-inflammatory pharmacotherapy. Vet Immunol Immunopathol 81:331-45, 2001.
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2001 Marsella,R.,Sousa,C.A.: :
The ACVD task force on canine atopic dermatitis (XIII): threshold phenomenon and summation of effects. Vet Immunol Immunopathol 81:251-4, 2001.
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2001 Mueller,R.S.,Bettenay,S.V.: :
Evaluation of the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. Am J Vet Res 62:307-10, 2001.
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2001 Nuttall,T.J.,Halliwell,R.E.W.: :
Serum antibodies to Malassezia yeasts in canine atopic dermatitis Veterinary Dermatology 12:327-332, 2001.
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2001 Nuttall,T.J.,Lamb,J.R.,Hill,P.B.: :
Characterisation of major and minor Dermatophagoides allergens in canine atopic dermatitis Research in Veterinary Science 71:51-57, 2001.
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2001 Nuttall,T.J.,Lamb,J.R.,Hill,P.B.: :
Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis Veterinary Immunology & Immunopathology 82:273-280, 2001.
2001 Olivry,T.,DeBoer,D.J.,Griffin,C.E.,Halliwell,R.E.,Hill,P.B.,Hillier,A.,Marsella,R.,Sousa,C.A.: :
The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol 81:143-6, 2001.
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2001 Olivry,T.,Hill,P.B.: :
The ACVD task force on canine atopic dermatitis (VIII): is the epidermal lipid barrier defective? Vet Immunol Immunopathol 81:215-8, 2001.
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2001 Olivry,T.,Hill,P.B.: :
The ACVD task force on canine atopic dermatitis (XVIII): histopathology of skin lesions. Vet Immunol Immunopathol 81:305-9, 2001.
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2001 Olivry,T.,Hill,P.B.: :
The ACVD task force on canine atopic dermatitis (IX): the controversy surrounding the route of allergen challenge in canine atopic dermatitis. Vet Immunol Immunopathol 81:219-25, 2001.
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2001 Olivry,T.,Marsella,R.,Hillier,A.: :
The ACVD task force on canine atopic dermatitis (XXIII): are essential fatty acids effective? Vet Immunol Immunopathol 81:347-62, 2001.
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2001 Olivry,T.,Sousa,C.A.: :
The ACVD task force on canine atopic dermatitis (XIX): general principles of therapy. Vet Immunol Immunopathol 81:311-6, 2001.
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2001 Olivry,T.,Sousa,C.A.: :
The ACVD task force on canine atopic dermatitis (XX): glucocorticoid pharmacotherapy. Vet Immunol Immunopathol 81:317-22, 2001.
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2001 Rees,C.A.: :
Canine and feline atopic dermatitis: A review of the diagnostic options Clinical Techniques in Small Animal Practice 16:230-232, 2001.
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2001 Sousa,C.A.,Halliwell,R.E.: :
The ACVD task force on canine atopic dermatitis (XI): the relationship between arthropod hypersensitivity and atopic dermatitis in the dog. Vet Immunol Immunopathol 81:233-7, 2001.
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2001 Sousa,C.A.,Marsella,R.: :
The ACVD task force on canine atopic dermatitis (II): genetic factors. Vet Immunol Immunopathol 81:153-7, 2001.
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2000 Masuda,K.,Tsujimoto,H.,Fujiwara,S.,Kurata,K.,Hasegawa,A.,Taniguchi,Y.,Yamashita,K.,Yasueda,H.,DeBoer,D.J.,de,Weck,A.L.,Sakaguchi,M.: :
IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis Veterinary Immunology & Immunopathology 74:263-270, 2000.
2000 McEwan,N.A.: :
Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis Research in Veterinary Science 68:279-283, 2000.
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2000 Mueller,R.S.,Bettenay,S.V.,Tideman,L.: :
Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests Australian Veterinary Journal 78:392-399, 2000.
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1999 DeBoer,D.J.,Hill,P.B.: :
Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis Veterinary Dermatology 10:275-281, 1999.
1999 Mueller,R.S.,Burrows,A.,Tsohalis,J.: :
Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs Australian Veterinary Journal 77:290-294, 1999.
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1998 Hammerling,R.,Leidinger,K.: :
Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German] Praktische Tierarzt 79:509 ff., 1998.
1998 Prelaud,P.,Guaguere,E.,Alhaidari,Z.,Faivre,N.,Heripret,D.,Gayerie,A.: :
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1997 Mueller,R.S.,Cannon,A.,Reubl,G.H.,Ihrke,P.J.: :
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1997 Olivry,T.,Naydan,D.K.,Moore,P.F.: :
Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis American Journal of Dermatopathology 19:477-486, 1997.
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