The detail information of Dermoid sinus
Basic Information

Disease Ontology ID: DDTO:0000956

Disease Description: Similar to a dermoid cyst but usually larger. Seen in Rhodesian ridgebacks.

Inherit Mode: Various modes of inheritance have been suggested including dominant with incomplete penetrance, or recessive. It is possible that there is an inherent deficiency in the Rhodesian Ridgeback breed in the absorption or utilization of folic acid (a B vitamin), that leads to this defect.

Disease Symptom: Dermoid sinus is present from birth, although thecondition isusually not noticed until later. The tracts contain debris from theskin - sebum (waxylubricating substance), dead skin cells, and hair - and commonlybecome infected andpainful. If the tract extends to the spinal canal, infection may causemeningitis ormyelitis, resulting in various neurologic signs such as local orgeneral spinal pain,stiffness, or weakness (depending on the location of the sinus).

Disease Cause: -

Disease Diagnose: You or your veterinarian may notice firm painfulswellings in themiddle of your dog's back, from which there may be some exudate. Acord of fibrous tissue(the tract) can usually be felt under the skin. Your veterinarian willtake x-rays using acontrast dye to determine the extent of the tract.

Treat Method: In an affected dog, the only successful treatmentis surgicalremoval of the the whole tract, which may be a simple procedure or itmay be fairlycomplicated if the tract extends into the vertebrae and spinal canal.Incomplete removalresults in recurrence. There is evidence that suggests folic acidsupplementation ofbreeding bitches (both before and during pregnancy) can reduce theoccurrence of thiscondition (see below). For the veterinarian: Meningitisor myelitis aretreated as appropriate. Laminectomy may be necessary to removeportions of the tract fromwithin the spinal canal.

Breeder Advice: Affected dogs and their close relatives should notbe bred. Breedersmay want to consider folic acid dietary supplementation of breedingbitches (see referencebelow).

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Dermoid sinus ridge; hair ridge Autosomal Dominant - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB48 German Boxer Fun-loving, bright, active and loyal 58.4-63.5 cm (male), 54.6-59.7 cm (female) 29.5-36.3 kg (male), females are about 6.8 kg less than male Germany
CB142 Irish Blue Terrier Smart and alert; people oriented, with a dash of Irish humor in his heart 45.7-49.5 cm (male), 44.5-48.3 cm (female) 15-18.1 kg (male), females weigh slightly less than males Ireland
CB204 Rhodesian Ridgeback Dignified, even tempered; affectionate toward loved ones, reserved with strangers 63.5-68.6 cm (male), 61-66 cm (female) 38.6 kg (male), 31.8 kg (female) Zimbabwe
CB218 Shih Tzu(Chrysanthemum Dog) Outgoing, affectionate, playful and charming 20.3-27.9 cm 4.1-7.3 kg China
CB262 Yorkshire Terrier Sprightly, tomboyish, and affectionate 17.8-20.3 cm 3.2 kg United Kingdom (England)
CB205 Rottweiler Reserved with strangers and affectionate and loyal with his family. 61-68.6 cm (male), 55.9-63.5 cm (female) 49.9-59 kg (male), 34.9-49.9 kg (female) Germany
Associated Disease Variants from OMIA
Gene Differential Expression
References
2015 Waldo,J.T.,Diaz,K.S.: :
Development and validation of a diagnostic test for Ridge allele copy number in Rhodesian Ridgeback dogs. Canine Genet Epidemiol 2:2, 2015.
Pubmed reference: 26401330 . DOI: 10.1186/s40575-015-0013-x .
2009 Andersson,L.: :
Genome-wide association analysis in domestic animals: a powerful approach for genetic dissection of trait loci. Genetica 136:341-9, 2009.
Pubmed reference: 18704695 . DOI: 10.1007/s10709-008-9312-4 .
2008 Rahal,S.,Mortari,AC.,Yamashita,S.,Filho,MM.,Hatschbac,E.,Sequeira,JL.: :
Magnetic resonance imaging in the diagnosis of type 1 dermoid sinus in two Rhodesian ridgeback dogs. Can Vet J 49:871-6, 2008.
Pubmed reference: 10713979 .
2007 Karlsson,E.K.,Baranowska,I.,Wade,C.M.,SalmonHillbertz,N.H.,Zody,M.C.,Anderson,N.,Biagi,T.M.,Patterson,N.,Pielberg,G.R.,Kulbokas,E.J.,Comstock,K.E.,Keller,E.T.,Mesirov,J.P.,vonEuler,H.,Kämpe,O.,Hedhammar,A.,Lander,E.S.,Andersson,G.,Andersson,L.,Lindblad-Toh,K.: :
Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 39:1321-8, 2007.
Pubmed reference: 17906626 . DOI: 10.1038/ng.2007.10 .
2007 SalmonHillbertz,N.H.,Isaksson,M.,Karlsson,E.K.,Hellmén,E.,Pielberg,G.R.,Savolainen,P.,Wade,C.M.,vonEuler,H.,Gustafson,U.,Hedhammar,A.,Nilsson,M.,Lindblad-Toh,K.,Andersson,L.,Andersson,G.: :
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet 39:1318-20, 2007.
Pubmed reference: 17906623 . DOI: 10.1038/ng.2007.4 .
2006 Hillbertz,NH.,Andersson,G.: :
Autosomal dominant mutation causing the dorsal ridge predisposes for dermoid sinus in Rhodesian ridgeback dogs. J Small Anim Pract 47:184-8, 2006.
Pubmed reference: 16573760 . DOI: 10.1111/j.1748-5827.2006.00016.x .
2005 Hillbertz,NH.: :
Inheritance of dermoid sinus in the Rhodesian ridgeback. J Small Anim Pract 46:71-4, 2005.
Pubmed reference: 15736812 .
2000 Tshamala,M.,Moens,Y.: :
True dermoid cyst in a Rhodesian ridgeback Journal of Small Animal Practice 41:352-353, 2000.
Pubmed reference: 11002937 .
1999 Cornegliani,L.,Ghibaudo,G.: :
A dermoid sinus in a Siberian Husky Veterinary Dermatology 10:47-49, 1999.
1998 Booth,M.J.: :
Atypical dermoid sinus in a chow chow dog Journal of the South African Veterinary Medical Association 69:102-104, 1998.
1996 Roberts, JG and Nicholls-Grzemski,FA :
` the Rhodesian Ridgeback presented at the WorldConference of Rhodesian Ridgebacks, Melbourne, Australia
1995 LeCouteur, R.A., Child, G. :
Diseases of thespinal cord W.B. Saunders Co., Toronto. S.J. Ettinger and E.C. Feldman (eds.) Textbookof Veterinary InternalMedicine. p. 629-696.
1995 Fatone,G.,Brunetti,A.,Lamagna,F.,Potena,A.: :
Dermoid sinus and spinal malformations in a Yorkshire terrier: Diagnosis and follow-up Journal of Small Animal Practice 36:178-180, 1995.
Pubmed reference: 7603060 .
1993 Marks,S.L.,Harari,J.,Dernell,W.S.: :
Dermoid Sinus in a Rhodesian Ridgeback Journal of Small Animal Practice 34:356-358, 1993.
1992 Kása,F.,Kása,G.,Kussinger,S.: :
[Dermoid sinus in a Rhodesian ridgeback. Case report]. Tierarztl Prax 20:628-31, 1992.
Pubmed reference: 1481220 .
1989 Williams,ML.: :
The ridgeback anomaly. Arch Dermatol 125:1144, 1989.
Pubmed reference: 2642687 .
1986 Gammie,JS.: :
Dermoid sinus removal in a rhodesian ridgeback dog. Can Vet J 27:250-1, 1986.
Pubmed reference: 17422670 .
1979 Hathcock,JT.,Clampett,EG.,Broadstone,RV.: :
Dermoid sinus in a Rhodesian Ridgeback. Vet Med Small Anim Clin 74:53-6, 1979.
Pubmed reference: 256350 .
1970 Antin,IP.: :
Dermoid sinus in a Rhodesian Ridgeback dog. J Am Vet Med Assoc 157:961-2, 1970.
Pubmed reference: 4919487 .
1966 Mann,G.E.,Stratton,J.: :
Dermoid sinus in the Rhodesian Ridgeback Journal of Small Animal Practice 7:631-642, 1966.
Pubmed reference: 5951011 .
1957 Lord,L.H.,Cawley,A.J.,Gilray,J.: :
Mid dorsal dermoid sinuses in Rhodesian Ridgeback dogs - a case report Journal of the American Veterinary Medical Association 131:515-518, 1957.