The detail information of Von Willebrand disease, generic
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: -

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Keeshen,T.P.,Case,J.B.,Runge,J.J.,Singh,A.,Mayhew,P.D.,Steffey,M.A.,Culp,W.T.N.: :
Outcome of laparoscopic ovariohysterectomy or ovariectomy in dogs with von Willebrand disease or factor VII deficiency: 20 cases (2012-2014). J Am Vet Med Assoc 251:1053-1058, 2017.
Pubmed reference: 29035661 . DOI: 10.2460/javma.251.9.1053 .
2009 Nichols,TC.,Dillow,AM.,Franck,HW.,Merricks,EP.,Raymer,RA.,Bellinger,DA.,Arruda,VR.,High,KA.: :
Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J 50:144-67, 2009.
Pubmed reference: 19293459 .
2005 Heseltine,JC.,Panciera,DL.,Troy,GC.,Monroe,WE.,Brooks,MB.,Feldman,BF.: :
Effect of levothyroxine administration on hemostatic analytes in Doberman Pinschers with von Willebrand disease. J Vet Intern Med 19:523-7, 2005.
Pubmed reference: 16095169 .
2000 Lobetti,R.G.,Dippenaar,T.: :
Von Willebrand's disease in the German shepherd dog Journal of the South African Veterinary Medical Association 71:118-121, 2000.
1999 Applewhite,A.A.,Wilkens,B.E.,McDonald,D.E.,Radasch,R.M.,Barstad,R.D.: :
Potential central nervous system complications of von Willebrand's disease Journal of the American Animal Hospital Association 35:423-429, 1999.
Pubmed reference: 10493419 .
1999 Brooks,M.: :
Hereditary bleeding disorders in dogs and cats Veterinary Medicine 94:555-564, 1999.
1999 Schwarz,H.P.,Dorner,F.,Mitterer,A.,Mundt,W.,Schlokat,U.,Pichler,L.,Turecek,P.L.: :
Preclinical evaluation of recombinant von Willebrand factor in a canine model of von Willebrand disease Wiener Klinische Wochenschrift 111:181-191, 1999.
Pubmed reference: 10226348 .
1999 Venta,P.J.,Vidal,M.: :
MspI RSP in exon 42 of the canine von Willebrand factor (VWF) gene Animal Genetics 30:229, 1999.
Pubmed reference: 10442993 .
1998 Brewer,G.J.: :
Von Willebrand disease DNA testing Canine Practice 23:27-28, 1998.
1998 Degopegui,R.R.,Feldman,B.F.: :
Acquired and inherited platelet dysfunction in small animals Compendium on Continuing Education for the Practicing Veterinarian 20:1039 ff., 1998.
1998 Ray,J.,Brooks,M.B.,Suh,Y.,Ray,K.: :
A PCR-RFLP marker in canine von willebrand factor gene (vwf) Animal Genetics 29:406-407, 1998.
Pubmed reference: 9800340 .
1998 Schwarz,H.P.,Dorner,F.,Mitterer,A.,Mundt,W.,Schlokat,U.,Pichler,L.,Turecek,P.L.: :
Evaluation of recombinant von Willebrand factor in a canine model of von Willebrand disease Haemophilia 4:53-62, 1998.
Pubmed reference: 10028320 .
1997 Arnold,S.,Muller,A.,Binder,H.,Meyers,K.,Giger,U.: :
Plasma von-willebrand-factor concentrations in bernese mountain dogs [German] Schweizer Archiv fur Tierheilkunde 139:177-182, 1997.
Pubmed reference: 9173518 .
1997 Stokol,T.,Trepanier,L.,Parry,B.W.,Finnin,B.C.: :
Pharmacokinetics of von Willebrand factor and factor VIII in canine von-Willebrand-disease and haemophilia A Research in Veterinary Science 63:23-27, 1997.
Pubmed reference: 9368952 .
1997 Turecek,P.L.,Gritsch,H.,Pichler,L.,Auer,W.,Fischer,B.,Mitterer,A.,Mundt,W.,Schlokat,U.,Dorner,F.,Erinkman,H.J.M.,Vanmourik,J.A.,Schwarz,H.P.: :
In vivo characterization of recombinant von willebrand factor in dogs with von-willebrand-disease Blood 90:3555-3567, 1997.
Pubmed reference: 9345039 .
1996 Anon.: :
Test identifies carriers of von Willebrands disease American Journal of Veterinary Research 57:1521, 1996.
1996 Brooks,M.,Raymond,S.,Catalfamo,J.: :
Severe, recessive von Willebrands disease in German Wirehaired Pointers Journal of the American Veterinary Medical Association 209:926 ff., 1996.
1996 Brooks,M.,Raymond,S.,Catalfamo,J.: :
Plasma von Willebrand factor antigen concentration as a predictor of von Willebrands disease status in German Wirehaired Pointers Journal of the American Veterinary Medical Association 209:930 ff., 1996.
1996 Holmes,N.G.,Shaw,S.C.,Dickens,H.F.,Coombes,L.M.,Ryder,E.J.,Littlewood,J.D.,Binns,M.M.: :
Von willebrands disease in UK Dobermanns - possible correlation of a polymorphic DNA marker with disease status Journal of Small Animal Practice 37:307-308, 1996.
Pubmed reference: 8840249 .
1996 Moser,J.,Meyers,K.M.,Meinkoth,J.H.,Brassard,J.A.: :
Temporal variation and factors affecting measurement of canine von willebrand factor American Journal of Veterinary Research 57:1288-1293, 1996.
Pubmed reference: 8874720 .
1996 Moser,J.,Meyers,K.M.,Russon,R.H.: :
Inheritance of von willebrand factor deficiency in doberman pinschers Journal of the American Veterinary Medical Association 209:1103 ff., 1996.
1996 Thomas,J.S.: :
von Willebrand's disease in the dog and cat. Vet Clin North Am Small Anim Pract 26:1089-110, 1996.
Pubmed reference: 8863392 .
1996 Thomas,J.S.: :
Von Willebrand's disease in the dog and cat Veterinary Clinics of North America - Small Animal Practice 26:1089 ff., 1996.
1995 Clark,P.,Parry,B.W.: :
Survey of Irish Wolfhounds in Australia for von Willebrands disease Australian Veterinary Journal 72:393, 1995.
Pubmed reference: 8599574 .
1995 Dunn,K.J.,Nicholls,P.K.,Dunn,J.K.,Herrtage,M.E.: :
Intracranial haemorrhage in a dobermann puppy with von Willebrand's disease Veterinary Record 136:635-636, 1995.
Pubmed reference: 7571271 .
1995 Slappendel,R.J.: :
Von Willebrand's disease in Dutch Kooiker dogs Veterinary Quarterly 17:S21-S22, 1995.
Pubmed reference: 7571294 .
1995 Stokol,T.,Parry,B.W.: :
Stability of von Willebrand factor and factor VIII in canine cryoprecipitate under various conditions of storage Research in Veterinary Science 59:152-155, 1995.
Pubmed reference: 8525105 .
1995 Stokol,T.,Parry,B.W.: :
Stability of canine factor VIII and von Willebrand factor antigen concentration in the frozen state Research in Veterinary Science 59:156-159, 1995.
Pubmed reference: 8525106 .
1995 Stokol,T.,Parry,B.W.,Mansell,P.D.: :
Von willebrands disease in scottish terriers in australia Australian Veterinary Journal 72:404-407, 1995.
Pubmed reference: 8929184 .
1995 Stokol,T.,Parry,B.W.,Mansell,P.D.: :
von Willebrand's disease in Dobermann dogs in Australia Australian Veterinary Journal 72:257-262, 1995.
Pubmed reference: 8534229 .
1994 Brassard,J.A.,Meyers,K.M.: :
von Willebrand factor is not altered in azotemic dogs with prolonged bleeding time Journal of Laboratory and Clinical Medicine 124:55-62, 1994.
Pubmed reference: 8035104 .
1994 Ching,Y.N.L.H.,Meyers,K.M.,Brassard,J.A.,Wardrop,K.J.: :
Effect of Cryoprecipitate and Plasma on Plasma Vonwillebrand Factor Multimeters and Bleeding Time in Doberman-Pinschers with Type-I Vonwillebrands Disease American Journal of Veterinary Research 55:102-110, 1994.
Pubmed reference: 8141483 .
1994 Locke,K.: :
Severe Haemorrhage in Dobermann Dogs with Vonwillebrand's Disease and Its Control During Surgery Australian Veterinary Journal 71:263, 1994.
Pubmed reference: 7986192 .
1993 Nichols,T.C.,Bellinger,D.A.,Reddick,R.L.,Smith,S.V.,Koch,G.G.,Davis,K.,Sigman,J.,Brinkhous,K.M.,Griggs,T.R.,Read,M.S.: :
The Roles of von Willebrand Factor and Factor-VIII in Arterial Thrombosis - Studies in Canine von Willebrand Disease and Hemophilia-A Blood 81:2644-2651, 1993.
Pubmed reference: 8490173 .
1993 Stokol,T.,Parry,B.W.: :
Canine Vonwillebrand Disease - A Review Australian Veterinary Practitioner 23:94-103, 1993.
1992 Benson,R.E.,Catalfamo,J.L.,Dodds,W.J.: :
A Multispecies Enzyme-Linked Immunosorbent Assay for Von Willebrand's Factor Journal of Laboratory and Clinical Medicine 119:420-427, 1992.
Pubmed reference: 1583394 .
1992 Brooks,M.: :
Management of canine von Willebrand's disease. Probl Vet Med 4:636-46, 1992.
Pubmed reference: 1472774 .
1992 Brooks,M.,Dodds,W.J.,Raymond,S.L.: :
Epidemiologic Features of von Willebrand's Disease in Doberman-Pinschers, Scottish Terriers, and Shetland Sheepdogs - 260 Cases (1984-1988) Journal of the American Veterinary Medical Association 200:1123-1127, 1992.
Pubmed reference: 1607320 .
1992 Huss,B.T.,Ettinger,S.J.: :
Visceral Leishmaniasis, Rocky Mountain Spotted Fever, and Vonwillebrand's Disease in a Giant Schnauzer Journal of the American Animal Hospital Association 28:221-225, 1992.
1992 Mansell,P.D.,Parry,B.W.: :
Changes in Factor 8 Activity and Vonwillebrand-Factor Antigen Concentration with Age in Dogs British Veterinary Journal 148:329-337, 1992.
Pubmed reference: 1498645 . DOI: 10.1016/0007-1935(92)90085-F .
1992 Mansell,P.D.,Parry,B.W.: :
Effect of Acepromazine, Xylazine and Thiopentone on Factor VIII Activity and Vonwillebrand Factor Antigen Concentration in Dogs Australian Veterinary Journal 69:187-190, 1992.
Pubmed reference: 1530553 .
1992 Meyers,K.M.,Wardrop,K.J.,Meinkoth,J.: :
Canine von Willebrand's Disease - Pathobiology, Diagnosis, and Short-Term Treatment Compendium on Continuing Education for the Practicing Veterinarian 14:13, 1992.
1992 Slappendel,R.J.,Frielink,R.A.J.,Mol,J.A.,Noordzij,A.,Hamer,R.: :
An Enzyme-Linked Immunosorbent Assay (ELISA) for Vonwillebrand Factor Antigen (vWf-Ag) in Canine Plasma Veterinary Immunology and Immunopathology 33:145-154, 1992.
Pubmed reference: 1632075 .
1991 Benson,R.E.,Catalfamo,J.L.,Brooks,M.,Dodds,W.J.: :
A Sensitive Immunoassay for von Willebrand Factor Journal of Immunoassay 12:371-390, 1991.
Pubmed reference: 1939665 . DOI: 10.1080/01971529108055078 .
1991 Brassard,J.A.,Meyers,K.M.: :
Evaluation of the Buccal Bleeding Time and Platelet Glass Bead Retention As Assays of Hemostasis in the Dog - The Effects of Acetylsalicylic Acid, Warfarin and Vonwillebrand Factor Deficiency Thrombosis and Haemostasis 65:191-195, 1991.
Pubmed reference: 2053106 .
1991 Brinkhous,K.M.,Reddick,R.L.,Read,M.S.,Nichols,T.C.,Bellinger,D.A.,Griggs,T.R.: :
von Willebrand Factor and Animal Models - Contributions to Gene Therapy, Thrombotic Thrombocytopenic Purpura, and Coronary Artery Thrombosis Mayo Clinic Proceedings 66:733-742, 1991.
Pubmed reference: 2072761 .
1991 Johnstone,I.B.,Crane,S.: :
Quantitation of Canine Plasma Von Willebrand Factor Antigen Using a Commercial Enzyme-Linked Immunosorbent Assay Canadian Journal of Veterinary Research-Revue Canadienne de Recherche Veterinaire 55:11-14, 1991.
Pubmed reference: 1884278 .
1991 Johnstone,I.B.,Keen,J.,Halbert,A.,Crane,S.: :
Stability of Factor-VIII and Vonwillebrand Factor in Canine Blood Samples During Storage Canadian Veterinary Journal-Revue Veterinaire Canadienne 32:173-175, 1991.
1991 Mansell,P.D.,Parry,B.W.: :
Stability of Canine Factor-VIII Activity and Vonwillebrand Factor Antigen Concentration Invitro Research in Veterinary Science 51:313-316, 1991.
Pubmed reference: 1780587 .
1991 Parker,M.T.,Turrentine,M.A.,Johnson,G.S.: :
Von Willebrand Factor in Lysates of Washed Canine Platelets American Journal of Veterinary Research 52:119-125, 1991.
Pubmed reference: 2021239 .
1990 Avgeris,S.,Lothrop,C.D.,Mcdonald,T.P.: :
Plasma Vonwillebrand Factor Concentration and Thyroid Function in Dogs Journal of the American Veterinary Medical Association 196:921-924, 1990.
Pubmed reference: 2107158 .
1990 Dueland,R.T.,Wagner,S.D.,Parker,R.B.: :
Vonwillebrand Heterotopic Osteochondrofibrosis in Doberman Pinschers - 5 Cases (1980-1987) Journal of the American Veterinary Medical Association 197:383-388, 1990.
Pubmed reference: 2118129 .
1990 Meyers,K.M.,Wardrop,K.J.,Dodds,W.J.,Brassard,J.: :
Effect of Exercise, Ddavp, and Epinephrine on the Factor VIII- C Vonwillebrand Factor Complex in Normal Dogs and Vonwillebrand Factor Deficient Doberman-Pinscher Dogs Thrombosis Research 57:97-108, 1990.
Pubmed reference: 2105540 .
1990 Meyers,K.M.,Wardrop,K.J.,Helmick,C.,White,F.: :
Vonwillebrand Factor Is Present in the Vascular Endothelium from Normal Dogs and from Doberman-Pinscher Dogs with a Plasma Vonwillebrand Factor Deficiency Thrombosis Research 57:109-116, 1990.
Pubmed reference: 2405539 .
1990 Raymond,S.L.,Jones,D.W.,Brooks,M.B.,Dodds,W.J.: :
Clinical and Laboratory Features of a Severe Form of Vonwillebrand Disease in Shetland Sheepdogs Journal of the American Veterinary Medical Association 197:1342-1346, 1990.
Pubmed reference: 2266049 .
1989 Brinkhous,K.M.,Hedner,U.,Garris,J.B.,Diness,V.,Read,M.S.: :
Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc Natl Acad Sci U S A 86:1382-6, 1989.
Pubmed reference: 2784006 .
1988 Johnson,G.S.,Turrentine,M.A.,Kraus,K.H.: :
Canine von Willebrand's disease. A heterogeneous group of bleeding disorders Veterinary Clinics of North America, Small Animal Practice 18:195-229, 1988.
1986 Randolph,J.F.,Center,S.A.,Dodds,W.J.: :
Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs. Cornell Vet 76:3-10, 1986.
Pubmed reference: 3484442 .
1981 Johnstone,I.B.,Crane,S.: :
Von Willebrand's disease in two families of Doberman Pinschers Canadian Veterinary Journal 22:239-243, 1981.
1978 Read,M.S.,Shermer,R.W.,Brinkhous,K.M.: :
Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. Proc Natl Acad Sci U S A 75:4514-8, 1978.
Pubmed reference: 309134 .
1977 Dodds,W.J.: :
Porcine and canine von Willebrand's disease Comparative Pathology Bulletin 9:2-, 1977.