Disease Detail Information

OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2015

Species-specific name: -

Species-specific symbol: CL/P

More detail information can see in

Associated Breeds

iDog Breed Number	Breed Name	Personality	Height	Weight	History	Breed Source
CB173	Nova Scotia Duck Tolling Retriever		45.7-53.3 cm (male), 43.2-50.8 cm (female)	15.9-22.7 kg		Canada

Associated Gene

There are no associated genes.

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2019	Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: : Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019. Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 .
2017	Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: : Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 .
2015	Wolf,Z.T.,Brand,H.A.,Shaffer,J.R.,Leslie,E.J.,Arzi,B.,Willet,C.E.,Cox,T.C.,McHenry,T.,Narayan,N.,Feingold,E.,Wang,X.,Sliskovic,S.,Karmi,N.,Safra,N.,Sanchez,C.,Deleyiannis,F.W.,Murray,J.C.,Wade,C.M.,Marazita,M.L.,Bannasch,D.L.: : Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet 11:e1005059, 2015. Pubmed reference: 25798845 . DOI: 10.1371/journal.pgen.1005059 .
2009	Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: : Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009. Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 .
1972	Edmonds,L.,Stewart,R.W.,Selby,L.: : Cleft lip and palate in dogs (Boxer breed): a preliminary report Carnivore Genetics Newsletter 9:204-209, 1972.
1961	Calnan,J.: : The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961. Pubmed reference: 13875838 .