The detail information of Osteosarcoma
OMIA Basic Information

Possible human homologues (MIM numbers): -

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: -

Species-specific symbol: OSA

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Jarvis,S.,Koumadoraki,E.,Madouros,N.,Sharif,S.,Saleem,A.,Khan,S.: :
Non-rodent animal models of osteosarcoma: A review. Cancer Treat Res Commun 27:100307, 2021.
Pubmed reference: 33453605 . DOI: 10.1016/j.ctarc.2021.100307 .
2021 Wilk,S.S.,Zabielska-Koczywąs,K.A.: :
Molecular mechanisms of canine osteosarcoma metastasis. Int J Mol Sci 22:, 2021.
Pubmed reference: 33807419 . DOI: 10.3390/ijms22073639 .
2019 Makielski,K.M.,Mills,L.J.,Sarver,A.L.,Henson,M.S.,Spector,L.G.,Naik,S.,Modiano,J.F.: :
Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review. Vet Sci 6:, 2019.
Pubmed reference: 31130627 . DOI: 10.3390/vetsci6020048 .
2018 Sakthikumar,S.,Elvers,I.,Kim,J.,Arendt,M.L.,Thomas,R.,Turner-Maier,J.,Swofford,R.,Johnson,J.,Schumacher,S.E.,Alföldi,J.,Axelsson,E.,Couto,C.G.,Kisseberth,W.C.,Pettersson,M.E.,Getz,G.,Meadows,J.R.S.,Modiano,J.F.,Breen,M.,Kierczak,M.,Forsberg-Nilsson,K.,Marinescu,V.D.,Lindblad-Toh,K.: :
<i>SETD2</i> Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma. Cancer Res 78:3421-3431, 2018.
Pubmed reference: 29724721 . DOI: 10.1158/0008-5472.CAN-17-3558 .
2018 Shao,Y.W.,Wood,G.A.,Lu,J.,Tang,Q.L.,Liu,J.,Molyneux,S.,Chen,Y.,Fang,H.,Adissu,H.,McKee,T.,Waterhouse,P.,Khokha,R.: :
Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene :, 2018.
Pubmed reference: 30093633 . DOI: 10.1038/s41388-018-0444-4 .
2017 Sapierzyński,R.,Czopowicz,M.: :
The animal-dependent risk factors in canine osteosarcomas. Pol J Vet Sci 20:293-298, 2017.
Pubmed reference: 28865206 . DOI: 10.1515/pjvs-2017-0035 .
2014 Davis,B.W.,Ostrander,E.A.: :
Domestic dogs and cancer research: a breed-based genomics approach. ILAR J 55:59-68, 2014.
Pubmed reference: 24936030 . DOI: 10.1093/ilar/ilu017 .
2013 Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013.
Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 .
2013 Dobson,J.M.: :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013.
Pubmed reference: 23738139 . DOI: 10.1155/2013/941275 .
2013 Karlsson,E.K.,Sigurdsson,S.,Ivansson,E.,Thomas,R.,Elvers,I.,Wright,J.,Howald,C.,Tonomura,N.,Perloski,M.,Swofford,R.,Biagi,T.,Fryc,S.,Anderson,N.,Courtay-Cahen,C.,Youell,L.,Ricketts,S.L.,Mandlebaum,S.,Rivera,P.,vonEuler,H.,Kisseberth,W.C.,London,C.A.,Lander,E.S.,Couto,G.,Comstock,K.,Starkey,M.P.,Modiano,J.F.,Breen,M.,Lindblad-Toh,K.: :
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol 14:R132, 2013.
Pubmed reference: 24330828 . DOI: 10.1186/gb-2013-14-12-r132 .
2012 Tsai,P.C.,Breen,M.: :
Array-based comparative genomic hybridization-guided identification of reference genes for normalization of real-time quantitative polymerase chain reaction assay data for lymphomas, histiocytic sarcomas, and osteosarcomas of dogs. Am J Vet Res 73:1335-43, 2012.
Pubmed reference: 22924713 . DOI: 10.2460/ajvr.73.9.1335 .
2010 Morello,E.,Martano,M.,Buracco,P.: :
Biology, diagnosis and treatment of canine appendicular osteosarcoma: Similarities and differences with human osteosarcoma. Vet J :, 2010.
Pubmed reference: 20889358 . DOI: 10.1016/j.tvjl.2010.08.014 .
2010 O'Donoghue,LE.,Ptitsyn,AA.,Kamstock,DA.,Siebert,J.,Thomas,RS.,Duval,DL.: :
Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome. BMC Cancer 10:506, 2010.
Pubmed reference: 20860831 . DOI: 10.1186/1471-2407-10-506 .
2010 Phillips,JC.,Lembcke,L.,Chamberlin,T.: :
A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26. Genomics 96:220-7, 2010.
Pubmed reference: 20647041 . DOI: 10.1016/j.ygeno.2010.07.002 .
2010 Rissetto,KC.,Rindt,H.,Selting,KA.,Villamil,JA.,Henry,CJ.,Reinero,CR.: :
Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma. Vet Immunol Immunopathol 135:137-45, 2010.
Pubmed reference: 20197202 . DOI: 10.1016/j.vetimm.2010.02.002 .
2010 Selvarajah,GT.,Kirpensteijn,J.: :
Prognostic and predictive biomarkers of canine osteosarcoma. Vet J 185:28-35, 2010.
Pubmed reference: 20493743 . DOI: 10.1016/j.tvjl.2010.04.010 .
2010 Sottnik,JL.,Rao,S.,Lafferty,MH.,Thamm,DH.,Morley,PS.,Withrow,SJ.,Dow,SW.: :
Association of Blood Monocyte and Lymphocyte Count and Disease-Free Interval in Dogs with Osteosarcoma. J Vet Intern Med :, 2010.
Pubmed reference: 20840314 . DOI: 10.1111/j.1939-1676.2010.0591.x .
2009 Fossey,SL.,Liao,AT.,McCleese,JK.,Bear,MD.,Lin,J.,Li,PK.,Kisseberth,WC.,London,CA.: :
Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer 9:81, 2009.
Pubmed reference: 7704483 . DOI: 10.3109/10611869408996814 .
2009 Selvarajah,GT.,Kirpensteijn,J.,vanWolferen,ME.,Rao,NA.,Fieten,H.,Mol,JA.: :
Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Mol Cancer 8:72, 2009.
Pubmed reference: 14761893 . DOI: 10.1152/ajpcell.00407.2003 .
2009 Thomas,R.,Wang,HJ.,Tsai,PC.,Langford,CF.,Fosmire,SP.,Jubala,CM.,Getzy,DM.,Cutter,GR.,Modiano,JF.,Breen,M.: :
Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Res 17:365-77, 2009.
Pubmed reference: 19337847 . DOI: 10.1007/s10577-009-9028-z .
2008 Kirpensteijn,J.,Kik,M.,Teske,E.,Rutteman,GR.: :
TP53 gene mutations in canine osteosarcoma. Vet Surg 37:454-60, 2008.
Pubmed reference: 18986312 . DOI: 10.1111/j.1532-950X.2008.00407.x .
2007 Phillips,JC.,Stephenson,B.,Hauck,M.,Dillberger,J.: :
Heritability and segregation analysis of osteosarcoma in the Scottish deerhound. Genomics 90:354-63, 2007.
Pubmed reference: 17628392 . DOI: 10.1016/j.ygeno.2007.05.001 .
2006 Khanna,C.,Lindblad-Toh,K.,Vail,D.,London,C.,Bergman,P.,Barber,L.,Breen,M.,Kitchell,B.,McNeil,E.,Modiano,JF.,Niemi,S.,Comstock,KE.,Ostrander,E.,Westmoreland,S.,Withrow,S.: :
The dog as a cancer model. Nat Biotechnol 24:1065-6, 2006.
Pubmed reference: 16964204 . DOI: 10.1038/nbt0906-1065b .
2005 Dow,S.,Elmslie,R.,Kurzman,I.,MacEwen,G.,Pericle,F.,Liggitt,D.: :
Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases. Hum Gene Ther 16:937-46, 2005.
Pubmed reference: 16076252 . DOI: 10.1089/hum.2005.16.937 .
2005 Mullins,MN.,Lana,SE.,Dernell,WS.,Ogilvie,GK.,Withrow,SJ.,Ehrhart,EJ.: :
Cyclooxygenase-2 expression in canine appendicular osteosarcomas. J Vet Intern Med 18:859-65, 2005.
Pubmed reference: 15638270 .
2004 Flint,AF.,U'Ren,L.,Legare,ME.,Withrow,SJ.,Dernell,W.,Hanneman,WH.: :
Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. Vet Pathol 41:291-6, 2004.
Pubmed reference: 15133183 . DOI: 10.1354/vp.41-3-291 .
2004 Khanna,C.,Wan,X.,Bose,S.,Cassaday,R.,Olomu,O.,Mendoza,A.,Yeung,C.,Gorlick,R.,Hewitt,SM.,Helman,LJ.: :
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 10:182-6, 2004.
Pubmed reference: 14704791 . DOI: 10.1038/nm982 .
2003 MacEwen,EG.,Kutzke,J.,Carew,J.,Pastor,J.,Schmidt,JA.,Tsan,R.,Thamm,DH.,Radinsky,R.: :
c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin Exp Metastasis 20:421-30, 2003.
Pubmed reference: 14524531 .
2002 Levine,RA.: :
Overexpression of the sis oncogene in a canine osteosarcoma cell line. Vet Pathol 39:411-2, 2002.
Pubmed reference: 12014510 .
2002 Levine,RA.,Forest,T.,Smith,C.: :
Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors. Vet Pathol 39:372-8, 2002.
Pubmed reference: 12014501 .
2000 Ferracini,R.,Angelini,P.,Cagliero,E.,Linari,A.,Martano,M.,Wunder,J.,Buracco,P.: :
MET oncogene aberrant expression in canine osteosarcoma. J Orthop Res 18:253-6, 2000.
Pubmed reference: 10815826 . DOI: 10.1002/jor.1100180213 .
1999 Mendoza,S.,Konishi,T.,Dernell,WS.,Withrow,SJ.,Miller,CW.: :
Status of the p53, Rb and MDM2 genes in canine osteosarcoma. Anticancer Res 18:4449-53, 1999.
Pubmed reference: 9891508 .
1998 Johnson,AS.,Couto,CG.,Weghorst,CM.: :
Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog. Carcinogenesis 19:213-7, 1998.
Pubmed reference: 9472714 .
1998 Ru,G.,Terracini,B.,Glickman,LT.: :
Host related risk factors for canine osteosarcoma. Vet J 156:31-9, 1998.
Pubmed reference: 9691849 .
1997 vanLeeuwen,IS.,Cornelisse,CJ.,Misdorp,W.,Goedegebuure,SA.,Kirpensteijn,J.,Rutteman,GR.: :
P53 gene mutations in osteosarcomas in the dog. Cancer Lett 111:173-8, 1997.
Pubmed reference: 9022143 .
1996 Sagartz,JE.,Bodley,WL.,Gamblin,RM.,Couto,CG.,Tierney,LA.,Capen,CC.: :
p53 tumor suppressor protein overexpression in osteogenic tumors of dogs. Vet Pathol 33:213-21, 1996.
Pubmed reference: 8801715 .