The detail information of Cryptorchidism
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB220 Siberian Husky 53.3-61 cm (male), 50.8-55.9 cm (female) 20-27.2 kg (male), 15.9-23.1 kg (female) Russia
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Krzeminska,P.,Stachowiak,M.,Skrzypski,M.,Nowak,T.,Maslak,A.,Switonski,M.: :
Altered expression of CYP17A1 and CYP19A1 in undescended testes of dogs with unilateral cryptorchidism. Anim Genet :, 2020.
Pubmed reference: 32657440 . DOI: 10.1111/age.12977 .
2019 Krzemińska,P.,D'Anza,E.,Ciotola,F.,Paciello,O.,Restucci,B.,Peretti,V.,Albarella,S.,Switonski,M.: :
Polymorphisms of MAMLD1, SRD5A2, and AR Candidate Genes in Seven Dogs (78,XY; SRY-Positive) Affected by Hypospadias or Cryptorchidism. Sex Dev :, 2019.
Pubmed reference: 31055572 . DOI: 10.1159/000500219 .
2013 Zhao,X.,Onteru,S.,Saatchi,M.,Garrick,D.,Rothschild,M.: :
A genome-wide association study for canine cryptorchidism in Siberian Huskies. J Anim Breed Genet :, 2013.
Pubmed reference: 24268032 . DOI: 10.1111/jbg.12064 .
2012 Meyers-Wallen,V.N.: :
Gonadal and sex differentiation abnormalities of dogs and cats. Sex Dev 6:46-60, 2012.
Pubmed reference: 22005097 . DOI: 10.1159/000332740 .
2012 Pathirana,I.N.,Yamasaki,H.,Kawate,N.,Tsuji,M.,Büllesbach,E.E.,Takahashi,M.,Hatoya,S.,Inaba,T.,Tamada,H.: :
Plasma insulin-like peptide 3 and testosterone concentrations in male dogs: changes with age and effects of cryptorchidism. Theriogenology 77:550-7, 2012.
Pubmed reference: 22015156 . DOI: 10.1016/j.theriogenology.2011.08.030 .
2012 Quartuccio,M.,Marino,G.,Garufi,G.,Cristarella,S.,Zanghì,A.: :
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. J Vet Sci 13:207-9, 2012.
Pubmed reference: 22705745 .
2011 Breshears,M.A.,Peters,J.L.: :
Ambiguous genitalia in a fertile, unilaterally cryptorchid male miniature schnauzer dog. Vet Pathol 48:1038-40, 2011.
Pubmed reference: 21248100 . DOI: 10.1177/0300985810396104 .
2010 Arrighi,S.,Bosi,G.,Groppetti,D.,Aralla,M.,Cremonesi,F.: :
An insight into testis and gubernaculum dynamics of INSL3-RXFP2 signalling during testicular descent in the dog. Reprod Fertil Dev 22:751-60, 2010.
Pubmed reference: 20450827 . DOI: 10.1071/RD09260 .
2010 Pathirana,IN.,Tanaka,K.,Kawate,N.,Tsuji,M.,Kida,K.,Hatoya,S.,Inaba,T.,Tamada,H.: :
Analysis of single nucleotide polymorphisms in the 3' region of the estrogen receptor 1 gene in normal and cryptorchid Miniature Dachshunds and Chihuahuas. J Reprod Dev 56:405-10, 2010.
Pubmed reference: 20453437 .
2010 Zhao,X.,Du,ZQ.,Rothschild,MF.: :
An association study of 20 candidate genes with cryptorchidism in Siberian Husky dogs. J Anim Breed Genet 127:327-31, 2010.
Pubmed reference: 20646120 . DOI: 10.1111/j.1439-0388.2010.00859.x .
2008 Birchard,SJ.,Nappier,M.: :
Cryptorchidism. Compend Contin Educ Vet 30:325-36; quiz 336-7, 2008.
Pubmed reference: 18690608 .
2004 vanHagen,MA.,Janss,LL.,vandenBroek,J.,Knol,BW.: :
The use of a genetic-counselling program by Dutch breeders for four hereditary health problems in boxer dogs. Prev Vet Med 63:39-50, 2004.
Pubmed reference: 15099715 . DOI: 10.1016/j.prevetmed.2004.01.007 .
2003 Ferlin,A.,Simonato,M.,Bartoloni,L.,Rizzo,G.,Bettella,A.,Dottorini,T.,Dallapiccola,B.,Foresta,C.: :
The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. J Clin Endocrinol Metab 88:4273-9, 2003.
Pubmed reference: 12970298 .
2003 Yates,D.,Hayes,G.,Heffernan,M.,Beynon,R.: :
Incidence of cryptorchidism in dogs and cats Veterinary Record 152:502-4, 2003.
Pubmed reference: 12733559 .
2001 Reif,U.,Walshaw,R.,Perry,R.: :
Urethradiverticulum, persistant urachusligament and torsion of a testis in a kryptorchid dog Kleintierpraxis 46:733-739, 2001.
2000 Tomboc,M.,Lee,P.A.,Mitwally,M.F.,Schneck,F.X.,Bellinger,M.,Witchel,S.F.: :
Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. J Clin Endocrinol Metab 85:4013-8, 2000.
Pubmed reference: 11095425 .
1996 Schulz,K.S.,Waldron,D.R.,Smith,M.M.,Henderson,R.A.,Howe,L.M.: :
Inadvertent prostatectomy as a complication of cryptorchidectomy in four dogs Journal of the American Animal Hospital Association 32:211-214, 1996.
Pubmed reference: 8731134 .
1995 Kawakami,E.,Tsutsui,T.,Saito,S.,Kakimoto,T.,Ogasa,A.: :
Changes in peripheral plasma luteinizing hormone and testosterone concentrations and semen quality in normal and cryptorchid dogs during sexual maturation Laboratory Animal Science 45:258-263, 1995.
Pubmed reference: 7650895 .
1994 Ayyappan,S.,Jayaprakash,R.,Tank,P.H.,David,W.P.A.,Balasubramanian,N.N.: :
Bilateral Inguinal Cryptorchidism with Sertoli Cell Tumour in a Dog - A Case Report Indian Veterinary Journal 71:915-917, 1994.
1993 Kawakami,E.,Hirayama,S.,Tsutsui,T.,Ogasa,A.: :
Pituitary Response of Cryptorchid Dogs to LH-RH-Analogue Before and After Sexual Maturation Journal of Veterinary Medical Science 55:147-148, 1993.
Pubmed reference: 8096403 .
1993 Metzger,F.L.,Hattel,A.L.,White,D.G.: :
Hematuria, Hyperestrogenemia, and Hyperprogesteronemia Due to a Sertoli-Cell Tumor in a Bilaterally Cryptorchid Dog Canine Practice 18:32-35, 1993.
1993 Ruble,R.P.,Hird,D.W.: :
Congenital Abnormalities in Immature Dogs from a Pet Store - 253 Cases (1987-1988) Journal of the American Veterinary Medical Association 202:633-636, 1993.
Pubmed reference: 8095494 .
1991 Romagnoli,S.E.: :
Canine Cryptorchidism Veterinary Clinics of North America - Small Animal Practice 21:533-544, 1991.
1989 Vanleeuwen,M.P.M.,Hunen,E.J.M.R.,Bouw,J.: :
Cryptorchidism in Dogs Tijdschrift Voor Diergeneeskunde 114:999-1005, 1989.
Pubmed reference: 2572074 .
1985 Hayes,H.M.,Wilson,G.P.,Pendergrass,T.W.,Cox,V.S.: :
Canine cryptorchism and subsequent testicular neoplasia: case-control study with epidemiologic update. Teratology 32:51-6, 1985.
Pubmed reference: 2863879 . DOI: 10.1002/tera.1420320108 .
1981 Baumans,B.,Dijkstra,G.,Wensing,C.J.G.: :
Testicular descent in the dog. Anat. Histol. Embryol. 10:97-110, 1981.
DOI: 10.1111/j.1439-0264.1981.tb00508.x .
1970 Turner,T.: :
Torsion of the retained testicle in the dog Journal of Small Animal Practice 11:436-437, 1970.
Pubmed reference: 4393846 .
1969 Gier,H.T.,Marion,G.B.: :
Development of mammalian testes and genital ducts. Biol Reprod 1:Suppl 1:1-23, 1969.
Pubmed reference: 5406326 .
1969 Lindo,D,E,Grenn,H.H.: :
Bilateral sertoli cell tumor in a canine cryptorchid with accompanying pathological lesions Canadian Veterinary Journal 10:145-147, 1969.
1969 Reif,J.S.,Brodey,R.S.: :
The relationship between cryptorchidism and canine testicular neoplasia Journal of the American Veterinary Medical Association 155:2005-2010, 1969.
Pubmed reference: 4391618 .
1960 Willis,M.B.: :
Inheritance of cryptorchidism Journal of Animal Health Trust :21-25, 1960.
1955 Anon.: :
Cryptorchidism in the dog Veterinary Record 67:472-474, 1955.
1938 Hartl,J.: :
Die verebung des Kryptorchismus beim Hund Kleinter u Pesztier 14:1-37, 1938.