The detail information of Deafness
OMIA Basic Information

Possible human homologues (MIM numbers): -

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: Congenital sensorineural deafness

Species-specific symbol: CSD

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB15 Australian Cattle Dog 45.7-50.8 cm (male), 43.2-48.3 cm (female) 15.9-22.7 kg Australia
CB43 Border Collie 48.3-55.9 cm (male), 45.7-53.3 cm (female) 13.6-20.4 kg (male), 12.2-19.1 kg (female) United Kingdom (Scotland, England, Wales)
CB57 English Bull Terrier 53.3-55.9 cm 22.7-31.8 kg United Kingdom (England)
CB65 Catahoula Leopard Dog 22-24 inches 50-95 pounds United States
CB84 Dalmatian 48.3-61 cm 20.4-31.8 kg Croatia
CB94 English Cocker Spaniel 40.6-43.2 cm (male), 38.1-40.6 cm (female) 12.7-15.4 kg (male), 11.8-14.5 kg (female) United Kingdom (England)
CB96 English Setter 63.5-68.6 cm (male), 58.4-63.5 cm (female) 29.5-36.3 kg (male), 20.4-24.9 kg (female) United Kingdom (England)
CB361 Kooikerhondje(Little Cager Dog) 35.6-40.6 cm Netherlands
CB256 English Whippet 48.3-55.9 cm (male), 45.7-53.3 cm (female) 11.3-18.1 kg England
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Hayward,J.J.,Kelly-Smith,M.,Boyko,A.R.,Burmeister,L.,DeRisio,L.,Mellersh,C.,Freeman,J.,Strain,G.M.: :
A genome-wide association study of deafness in three canine breeds. PLoS One 15:e0232900, 2020.
Pubmed reference: 32413090 . DOI: 10.1371/journal.pone.0232900 .
2020 Kelly-Smith,M.,Strain,G.M.: :
STRING data mining of GWAS data in canine hereditary pigment-associated deafness. Vet Anim Sci 9:100118, 2020.
Pubmed reference: 32734119 . DOI: 10.1016/j.vas.2020.100118 .
2020 Lewis,T.,Freeman,J.,DeRisio,L.: :
Decline in prevalence of congenital sensorineural deafness in Dalmatian dogs in the United Kingdom. J Vet Intern Med :, 2020.
Pubmed reference: 32543777 . DOI: 10.1111/jvim.15776 .
2020 Marsh,O.J.R.,Freeman,J.,VanDijk,J.,DeRisio,L.: :
Congenital sensorineural deafness in English setters in the United Kingdom: prevalence and association with phenotype and sex. Vet Rec 186:e13, 2020.
Pubmed reference: 31662574 . DOI: 10.1136/vr.105636 .
2016 DeRisio,L.,Freeman,J.,Lewis,T.: :
Prevalence, heritability and genetic correlations of congenital sensorineural deafness and coat pigmentation phenotype in the English bull terrier. BMC Vet Res 12:146, 2016.
Pubmed reference: 27443656 . DOI: 10.1186/s12917-016-0777-6 .
2015 Strain,G.M.: :
The Genetics of Deafness in Domestic Animals. Front Vet Sci 2:29, 2015.
Pubmed reference: 26664958 . DOI: 10.3389/fvets.2015.00029 .
2014 Blum,M.,Distl,O.: :
[Phenotypic trends and breeding values for canine congenital sensorineural deafness in Dalmatian dogs]. Berl Munch Tierarztl Wochenschr 127:70-6, 2014.
Pubmed reference: 24490346 .
2013 Kluth,S.,Distl,O.: :
Congenital sensorineural deafness in dalmatian dogs associated with quantitative trait Loci. PLoS One 8:e80642, 2013.
Pubmed reference: 24324618 . DOI: 10.1371/journal.pone.0080642 .
2012 Comito,B.,Knowles,K.E.,Strain,G.M.: :
Congenital deafness in Jack Russell terriers: prevalence and association with phenotype. Vet J 193:404-7, 2012.
Pubmed reference: 22456033 . DOI: 10.1016/j.tvjl.2012.02.018 .
2012 Sommerlad,S.F.,Morton,J.M.,Haile-Mariam,M.,Johnstone,I.,Seddon,J.M.,O'Leary,C.A.: :
Prevalence of congenital hereditary sensorineural deafness in Australian Cattle Dogs and associations with coat characteristics and sex. BMC Vet Res 8:202, 2012.
Pubmed reference: 23107143 . DOI: 10.1186/1746-6148-8-202 .
2012 Strain,G.M.: :
Canine deafness. Vet Clin North Am Small Anim Pract 42:1209-24, 2012.
Pubmed reference: 23122177 . DOI: 10.1016/j.cvsm.2012.08.010 .
2011 DeRisio,L.,Lewis,T.,Freeman,J.,deStefani,A.,Matiasek,L.,Blott,S.: :
Prevalence, heritability and genetic correlations of congenital sensorineural deafness and pigmentation phenotypes in the Border Collie. Vet J 188:286-90, 2011.
Pubmed reference: 20570536 . DOI: 10.1016/j.tvjl.2010.05.012 .
2010 Sommerlad,S.,McRae,AF.,McDonald,B.,Johnstone,I.,Cuttell,L.,Seddon,JM.,O'Leary,CA.: :
Congenital Sensorineural Deafness in Australian Stumpy-Tail Cattle Dogs Is an Autosomal Recessive Trait That Maps to CFA10. PLoS One 5:e13364, 2010.
Pubmed reference: 20967282 . DOI: 10.1371/journal.pone.0013364 .
2009 Strain,GM.,Clark,LA.,Wahl,JM.,Turner,AE.,Murphy,KE.: :
Prevalence of deafness in dogs heterozygous or homozygous for the merle allele. J Vet Intern Med 23:282-6, 2009.
Pubmed reference: 19192156 . DOI: 10.1111/j.1939-1676.2008.0257.x .
2009 Stritzel,S.,Wöhlke,A.,Distl,O.: :
A role of the microphthalmia-associated transcription factor in congenital sensorineural deafness and eye pigmentation in Dalmatian dogs. J Anim Breed Genet 126:59-62, 2009.
Pubmed reference: 19207931 . DOI: 10.1111/j.1439-0388.2008.00761.x .
2007 Famula,TR.,Cargill,EJ.,Strain,GM.: :
Heritability and complex segregation analysis of deafness in Jack Russell Terriers. BMC Vet Res 3:31, 2007.
Pubmed reference: 17999773 . DOI: 10.1186/1746-6148-3-31 .
2006 Platt,S.,Freeman,J.,diStefani,A.,Wieczorek,L.,Henley,W.: :
Prevalence of unilateral and bilateral deafness in border collies and association with phenotype. J Vet Intern Med 20:1355-62, 2006.
Pubmed reference: 17186850 .
2005 Rak,SG.,Distl,O.: :
Congenital sensorineural deafness in dogs: a molecular genetic approach toward unravelling the responsible genes. Vet J 169:188-96, 2005.
Pubmed reference: 15727910 . DOI: 10.1016/j.tvjl.2004.01.015 .
2004 Cargill,EJ.,Famula,TR.,Strain,GM.,Murphy,KE.: :
Heritability and segregation analysis of deafness in U.S. Dalmatians. Genetics 166:1385-93, 2004.
Pubmed reference: 15082557 .
2004 Strain,GM.: :
Deafness prevalence and pigmentation and gender associations in dog breeds at risk. Vet J 167:23-32, 2004.
Pubmed reference: 14623147 .
2003 Brenig,B.,Pfeiffer,I.,Jaggy,A.,Kathmann,I.,Balzari,M.,Gaillard,C.,Dolf,G.: :
Analysis of the 5' region of the canine PAX3 gene and exclusion as a candidate for Dalmatian deafness. Anim Genet 34:47-50, 2003.
Pubmed reference: 12580786 .
2003 Juraschko,K.,Meyer-Lindenberg,A.,Nolte,I.,Distl,O.: :
Analysis of systematic effects on congenital sensorineural deafness in German Dalmatian dogs.[comment] Veterinary Journal 166:164-9, 2003.
2003 Juraschko,K.,Meyer-Lindenberg,A.,Nolte,I.,Distl,O.: :
A regressive model analysis of congenital sensorineural deafness in German Dalmatian dogs. Mamm Genome 14:547-54, 2003.
Pubmed reference: 12925887 . DOI: 10.1007/s00335-002-3033-2 .
2002 Muhle,A.C.,Jaggy,A.,Stricker,C.,Steffen,F.,Dolf,G.,Busato,A.,Kornberg,M.,Mariscoliy,M.,Sprenk,P.,Gaillard,C.: :
Further contributions to the genetic aspect of congenital sensorineural deafness in Dalmatians Veterinary Journal 163:311-318, 2002.
2000 Coppens,A.G.,Resibois,A.,Poncelet,L.: :
Bilateral deafness in a Maltese terrier and a Great Pyrenean puppy: Inner ear morphology Journal of Comparative Pathology 122:223-228, 2000.
Pubmed reference: 10684693 . DOI: 10.1053/jcpa.1999.0360 .
2000 Famula,T.R.,Oberbauer,A.M.,Sousa,C.A.: :
Complex segregation analysis of deafness in Dalmatians American Journal of Veterinary Research 61:550-553, 2000.
Pubmed reference: 10803651 .
2000 Rollin,B.E.: :
An ethicist's commentary on euthanizing deaf Dalmatian puppies (vol 41, pg 438, 2000) Canadian Veterinary Journal - Revue Veterinaire Canadienne 41:537, 2000.
1999 Cattanach,B.: :
The 'dalmatian dilemma': white coat colour and deafness Journal of Small Animal Practice 40:193-+, 1999.
Pubmed reference: 10340252 .
1999 Poncelet,L.,Coppens,A.,Deltenre,P.: :
Puppy dogs deafness in Belgium: a two years retrospective study [French] Annales de Medecine Veterinaire 143:41-45, 1999.
1999 Strain,G.M.: :
Congenital deafness and its recognition Veterinary Clinics of North America - Small Animal Practice 29:895-+, 1999.
1998 Steffen,F.,Jaggy,A.: :
Deafness and its diagnosis in dogs and cats [German] Schweizer Archiv fur Tierheilkunde 140:397-404, 1998.
Pubmed reference: 9803159 .
1998 Wood,J.L.N.,Lakhani,K.H.: :
Deafness in dalmatians - does sex matter Preventive Veterinary Medicine 36:39-50, 1998.
Pubmed reference: 9677626 .
1997 Townsend,H.G.G.: :
101 dalmatians - but how many are congenitally deaf Veterinary Journal 154:89-90, 1997.
1997 Wood,J.L.N.,Lakhani,K.H.: :
Prevalence and prevention of deafness in the dalmatian - assessing the effect of parental hearing status and gender using ordinary logistic and generalized random litter effect models Veterinary Journal 154:121-133, 1997.
1996 Famula,T.R.,Oberbauer,A.M.,Sousa,C.A.: :
A threshold model analysis of deafness in dalmatians Mammalian Genome 7:650-653, 1996.
Pubmed reference: 8703116 .
1996 Strain,G.M.: :
Aetiology, prevalence and diagnosis of deafness in dogs and cats [Review] British Veterinary Journal 152:17-36, 1996.
Pubmed reference: 8634862 .
1996 Wood,J.L.N.,Delauche,A.J.,Lakhani,K.H.: :
The problem of inherited diseases. 6. Deafness in Dalmatians Journal of Small Animal Practice 37:559-561, 1996.
Pubmed reference: 8934431 .
1994 Greibrokk,T.: :
Hereditary Deafness in the Dalmatian - Relationship to Eye and Coat Color Journal of the American Animal Hospital Association 30:170-176, 1994.
1994 Steinberg,S.A.,Klein,E.,Killens,R.L.,Uhde,T.W.: :
Inherited Deafness Among Nervous Pointer Dogs Journal of Heredity 85:56-59, 1994.
Pubmed reference: 8120360 .
1994 Turner,S.: :
Deafness in Dalmatians and Other Breeds Veterinary Record 134:200, 1994.
Pubmed reference: 8171802 .
1992 Holliday,T.A.,Nelson,H.J.,Williams,D.C.,Willits,N.: :
Unilateral and Bilateral Brainstem Auditory-Evoked Response Abnormalities in 900 Dalmatian Dogs Journal of Veterinary Internal Medicine 6:166-174, 1992.
Pubmed reference: 1619593 .
1992 Strain,G.M.,Kearney,M.T.,Gignac,I.J.,Levesque,D.C.,Nelson,H.J.,Tedford,B.L.,Remsen,L.G.: :
Brainstem Auditory-Evoked Potential Assessment of Congenital Deafness in Dalmatians - Associations with Phenotypic Markers Journal of Veterinary Internal Medicine 6:175-182, 1992.
Pubmed reference: 1619594 .
1991 Strain,G.M.: :
Congenital Deafness in Dogs and Cats Compendium on Continuing Education for the Practicing Veterinarian 13:245, 1991.
1985 Sims,MH.,Shull-Selcer,E.: :
Electrodiagnostic evaluation of deafness in two English setter littermates. J Am Vet Med Assoc 187:398-404, 1985.
Pubmed reference: 4030474 .
1981 Gwin,R.M.,Wyman,M.,Lim,D.J.,Ketring,K.,Werling,K.: :
Multiple ocular defects associated with partial albinism and deafness in the dog Journal of the American Animal Hospital Association 17:401-408, 1981.
1977 Anniko,M.,Fabiansson,E.,Nilsson,O.: :
Deafness in an old English sheepdog. A case report. Arch Otorhinolaryngol 218:1-7, 1977.
Pubmed reference: 579985 .
1967 Roberts,S.R.: :
Colour dilution and hereditary defects in Collie dogs American Journal of Ophthalmology 63:1762-1775, 1967.
Pubmed reference: 4961230 .
1956 Adams,E.W.: :
Hereditary deafness in a family of Foxhounds Journal of the American Veterinary Medical Association 128:302-303, 1956.
Pubmed reference: 13295142 .
1933 Gray,H.: :
Congenital deafness in dogs Our Dog 91:490, 1933.