The detail information of Hypoadrenocorticism
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: unknown

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Gershony,L.C.,Belanger,J.M.,Hytönen,M.K.,Lohi,H.,Famula,T.R.,Oberbauer,A.M.: :
Correction to: Genetic characterization of Addison's disease in Bearded Collies. BMC Genomics 21:898, 2020.
Pubmed reference: 33380317 . DOI: 10.1186/s12864-020-07328-w .
2020 Gershony,L.C.,Belanger,J.M.,Hytönen,M.K.,Lohi,H.,Famula,T.R.,Oberbauer,A.M.: :
Genetic characterization of Addison's disease in Bearded Collies. BMC Genomics 21:833, 2020.
Pubmed reference: 33243158 . DOI: 10.1186/s12864-020-07243-0 .
2019 Gershony,L.C.,Belanger,J.M.,Short,A.D.,Le,M.,Hytönen,M.K.,Lohi,H.,Famula,T.R.,Kennedy,L.J.,Oberbauer,A.M.: :
DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genet Epidemiol 6:2, 2019.
Pubmed reference: 30783534 . DOI: 10.1186/s40575-019-0070-7 .
2019 Treeful,A.E.,Rendahl,A.K.,Friedenberg,S.G.,Treeful,A.E.,Rendahl,A.K.,Friedenberg,S.G.: :
DLA class II haplotypes show sex-specific associations with primary hypoadrenocorticism in Standard Poodle dogs. Immunogenetics 71:373-382, 2019.
Pubmed reference: 30968193 . DOI: 10.1007/s00251-019-01113-0 .
2018 Lathan,P.,Thompson,A.L.: :
Management of hypoadrenocorticism (Addison's disease) in dogs. Vet Med (Auckl) 9:1-10, 2018.
Pubmed reference: 30050862 . DOI: 10.2147/VMRR.S125617 .
2017 Friedenberg,S.G.,Lunn,K.F.,Meurs,K.M.: :
Evaluation of the genetic basis of primary hypoadrenocorticism in Standard Poodles using SNP array genotyping and whole-genome sequencing. Mamm Genome 28:56-65, 2017.
Pubmed reference: 27864587 . DOI: 10.1007/s00335-016-9671-6 .
2017 Wakayama,J.A.,Furrow,E.,Merkel,L.K.,Armstrong,P.J.: :
A retrospective study of dogs with atypical hypoadrenocorticism: a diagnostic cut-off or continuum? J Small Anim Pract :, 2017.
Pubmed reference: 28247992 . DOI: 10.1111/jsap.12649 .
2016 Gold,A.J.,Langlois,D.K.,Refsal,K.R.: :
Evaluation of basal serum or plasma cortisol concentrations for the diagnosis of hypoadrenocorticism in dogs. J Vet Intern Med :, 2016.
Pubmed reference: 27714859 . DOI: 10.1111/jvim.14589 .
2015 Hanson,J.M.,Tengvall,K.,Bonnett,B.N.,Hedhammar,Å.: :
Naturally occurring adrenocortical insufficiency--An epidemiological study based on a Swedish-insured dog population of 525,028 Dogs. J Vet Intern Med 30:76-84, 2015.
Pubmed reference: 26683136 . DOI: 10.1111/jvim.13815 .
2015 Pedersen,N.C.,Brucker,L.,Tessier,N.G.,Liu,H.,Penedo,M.C.,Hughes,S.,Oberbauer,A.,Sacks,B.: :
The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison's disease. Canine Genet Epidemiol 2:14, 2015.
Pubmed reference: 26401342 . DOI: 10.1186/s40575-015-0026-5 .
2014 Boag,A.M.,Catchpole,B.: :
A review of the genetics of hypoadrenocorticism. Top Companion Anim Med 29:96-101, 2014.
Pubmed reference: 25813849 . DOI: 10.1053/j.tcam.2015.01.001 .
2014 Short,A.D.,Catchpole,B.,Boag,A.M.,Kennedy,L.J.,Massey,J.,Rothwell,S.,Henthorn,P.S.,Littman,M.P.,Husebye,E.,Ollier,B.: :
Putative candidate genes for canine hypoadrenocorticism (Addison's disease) in multiple dog breeds. Vet Rec :, 2014.
Pubmed reference: 25124887 . DOI: 10.1136/vr.102160 .
2014 VanLanen,K.,Sande,A.: :
Canine hypoadrenocorticism: pathogenesis, diagnosis, and treatment. Top Companion Anim Med 29:88-95, 2014.
Pubmed reference: 25813848 . DOI: 10.1053/j.tcam.2014.10.001 .
2013 Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013.
Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 .
2013 Massey,J.,Boag,A.,Short,A.D.,Scholey,R.A.,Henthorn,P.S.,Littman,M.P.,Husebye,E.,Catchpole,B.,Pedersen,N.,Mellersh,C.S.,Ollier,W.E.,Kennedy,L.J.: :
MHC class II association study in eight breeds of dog with hypoadrenocorticism. Immunogenetics 65:291-7, 2013.
Pubmed reference: 23358933 . DOI: 10.1007/s00251-013-0680-2 .
2013 Short,A.D.,Boag,A.,Catchpole,B.,Kennedy,L.J.,Massey,J.,Rothwell,S.,Husebye,E.,Ollier,B.: :
A candidate gene analysis of canine hypoadrenocorticism in 3 dog breeds. J Hered :, 2013.
Pubmed reference: 23997205 . DOI: 10.1093/jhered/est051 .
2010 Hughes,AM.,Jokinen,P.,Bannasch,DL.,Lohi,H.,Oberbauer,AM.: :
Association of a dog leukocyte antigen class II haplotype with hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Tissue Antigens 75:684-90, 2010.
Pubmed reference: 20136772 . DOI: 10.1111/j.1399-0039.2010.01440.x .
2010 Klein,SC.,Peterson,ME.: :
Canine hypoadrenocorticism: Part I. Can Vet J 51:63-9, 2010.
Pubmed reference: 20357943 .
2010 Klein,SC.,Peterson,ME.: :
Canine hypoadrenocorticism: part II. Can Vet J 51:179-84, 2010.
Pubmed reference: 20436864 .
2009 Gow,AG.,Gow,DJ.,Bell,R.,Simpson,JW.,Chandler,ML.,Evans,H.,Berry,JL.,Herrtage,ME.,Mellanby,RJ.: :
Calcium metabolism in eight dogs with hypoadrenocorticism. J Small Anim Pract 50:426-30, 2009.
Pubmed reference: 19689671 . DOI: 10.1111/j.1748-5827.2009.00757.x .
2009 Hughes,AM.,Bannasch,DL.,Kellett,K.,Oberbauer,AM.: :
Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Vet J :, 2009.
Pubmed reference: 19931476 . DOI: 10.1016/j.tvjl.2009.10.012 .
2008 Adamantos,S.,Boag,A.: :
Total and ionised calcium concentrations in dogs with hypoadrenocorticism. Vet Rec 163:25-6, 2008.
Pubmed reference: 18603632 .
2008 Lathan,P.,Moore,GE.,Zambon,S.,Scott-Moncrieff,JC.: :
Use of a low-dose ACTH stimulation test for diagnosis of hypoadrenocorticism in dogs. J Vet Intern Med 22:1070-3, 2008.
Pubmed reference: 18537878 . DOI: 10.1111/j.1939-1676.2008.0118.x .
2007 Greco,DS.: :
Hypoadrenocorticism in small animals. Clin Tech Small Anim Pract 22:32-5, 2007.
Pubmed reference: 17542195 . DOI: 10.1053/j.ctsap.2007.02.005 .
2007 Hughes,AM.,Nelson,RW.,Famula,TR.,Bannasch,DL.: :
Clinical features and heritability of hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers: 25 cases (1994-2006). J Am Vet Med Assoc 231:407-12, 2007.
Pubmed reference: 17669043 . DOI: 10.2460/javma.231.3.407 .
2006 Chase,K.,Sargan,D.,Miller,K.,Ostrander,EA.,Lark,KG.: :
Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs. Int J Immunogenet 33:179-84, 2006.
Pubmed reference: 16712648 . DOI: 10.1111/j.1744-313X.2006.00593.x .
2006 Oberbauer,AM.,Bell,JS.,Belanger,JM.,Famula,TR.: :
Genetic evaluation of Addison's disease in the Portuguese Water Dog. BMC Vet Res 2:15, 2006.
Pubmed reference: 16670022 . DOI: 10.1186/1746-6148-2-15 .
2005 Jarrett,RH.,Norman,EJ.,Squires,RA.: :
Liquorice and canine Addison's disease. N Z Vet J 53:214, 2005.
Pubmed reference: 16012593 . DOI: 10.1080/00480169.2005.36508 .
2005 Rockwell,J.,Monroe,WE.,Tromblee,TC.: :
Spontaneous hypoadrenocorticism in a dog after a diagnosis of hyperadrenocorticism. J Vet Intern Med 19:299-300, 2005.
Pubmed reference: 15822572 .
2003 Famula,T.R.,Belanger,J.M.,Oberbauer,A.M.: :
Heritability and complex segregation analysis of hypoadrenocorticism in the standard poodle Journal of Small Animal Practice 44:8-12, 2003.
Pubmed reference: 12570345 .
2002 Oberbauer,A.M.,Benemann,K.S.,Belanger,J.M.,Wagner,D.R.,Ward,J.H.,Famula,T.R.: :
Inheritance of hypoadrenocorticism in Bearded Collies American Journal of Veterinary Research 63:643-647, 2002.
Pubmed reference: 12013462 .
2000 Greco,D.S.: :
Hypoadrenocorticism in dogs and cats Veterinary Medicine 95:468-+, 2000.
2000 Mansfield,C.S.: :
Glucocorticoid deficiency (atypical hypoadrenocorticism) and exocrine pancreatic insufficiency in a German Shepherd Dog Australian Veterinary Practitioner 30:2-5, 2000.
1999 Hoerauf,A.,Reusch,C.: :
Ultrasonographic evaluation of the adrenal glands in six dogs with hypoadrenocorticism Journal of the American Animal Hospital Association 35:214-218, 1999.
Pubmed reference: 10333259 .
1998 Kelch,W.J.,Smith,C.A.,Lynn,R.C.,New,J.C.: :
Canine hypoadrenocorticism (Addisons-disease) Compendium on Continuing Education for the Practicing Veterinarian 20:921 ff., 1998.
1998 Syme,H.M.,Scottmoncrieff,J.C.: :
Chronic hypoglycaemia in a hunting dog due to secondary hypoadrenocorticism Journal of Small Animal Practice 39:348-351, 1998.
Pubmed reference: 9693421 .
1998 Vollmar,A.,Hoppen,H.O.,Ueberschar,S.: :
Secondary hypoadrenocorticism in a 4 month old Irish Wolfhound [German] Kleintierpraxis 43:453 ff., 1998.
1997 Burton,S.,Delay,J.,Holmes,A.,Somerville,C.,Eye,J.,Shaw,D.,Wack,O.,Hanna,P.: :
Hypoadrenocorticism in young related Nova Scotia Duck Tolling Retrievers Canadian Veterinary Journal - Revue Veterinaire Canadienne 38:231-234, 1997.
1997 Hirt,R.,Kleiter,M.: :
Hypoadrenocorticism - a diagnostic challenge [German] Kleintierpraxis 42:779 ff., 1997.
1997 Kintzer,P.P.,Peterson,M.E.: :
Treatment and long-term follow-up of 205 dogs with hypoadrenocorticism Journal of Veterinary Internal Medicine 11:43-49, 1997.
Pubmed reference: 9127289 .
1997 Kintzer,P.P.,Peterson,M.E.: :
Primary and secondary hypoadrenocorticism Veterinary Clinics of North America - Small Animal Practice 27:349 ff., 1997.
1997 Koch,J.,Jensen,A.L.,Wenck,A.,Iversen,L.,Lykkegaard,K.: :
Duplex doppler measurements of renal blood flow in a dog with addisons disease Journal of Small Animal Practice 38:124-126, 1997.
Pubmed reference: 9097245 .
1996 Lifton,S.J.,King,L.G.,Zerbe,C.A.: :
Glucocorticoid deficient hypoadrenocorticism in dogs - 18 cases (1986-1995) Journal of the American Veterinary Medical Association 209:2076-2081, 1996.
Pubmed reference: 8960190 .
1996 Melian,C.,Peterson,M.E.: :
Diagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogs Journal of Small Animal Practice 37:268-275, 1996.
Pubmed reference: 8805097 .
1996 Peterson,M.E.,Kintzer,P.P.,Kass,P.H.: :
Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism - 225 cases (1979-1993) Journal of the American Veterinary Medical Association 208:85-91, 1996.
Pubmed reference: 8682712 .
1996 Sadek,D.,Schaer,M.: :
Atypical addisons disease in the dog - a retrospective survey of 14 cases Journal of the American Animal Hospital Association 32:159-163, 1996.
Pubmed reference: 8680923 .
1995 Dixon,R.: :
The most common causes of hyperkalaemia in the dog are hypoadrenocorticism (Addison's disease), acute renal failure, and urethral obstruction Journal of Small Animal Practice 36:49, 1995.
Pubmed reference: 7723288 .
1995 Langlaisburgess,L.,Lumsden,J.H.,Mackin,A.: :
Concurrent hypoadrenocorticism and hypoalbuminemia in dogs Journal of the American Animal Hospital Association 31:307-311, 1995.
Pubmed reference: 7552662 .
1994 Boujon,C.E.,Bornandjaunin,V.,Scharer,V.,Rossi,G.L.,Bestetti,G.E.: :
Pituitary gland changes in canine hypoadrenocorticism: A functional and immunocytochemical study Journal of Comparative Pathology 111:287-295, 1994.
Pubmed reference: 7836570 .
1994 Kemppainen,R.J.,Clark,T.P.,Peterson,M.E.: :
Preservative effect of aprotinin on canine plasma immunoreactive adrenocorticotropin concentrations Domestic Animal Endocrinology 11:355-362, 1994.
Pubmed reference: 7530181 .
1994 Kintzer,P.P.,Peterson,M.E.: :
Diagnosis and Management of Primary Spontaneous Hypoadrenocorticism (Addison's Disease) in Dogs Seminars in Veterinary Medicine and Surgery - Small Animal 9:148-152, 1994.
Pubmed reference: 7938935 .
1994 Vanzyl,M.,Hyman,W.B.: :
Desoxycorticosterone pivalate in the management of canine primary hypoadrenocorticism. Journal of the South African Veterinary Association - Tydskrif Van Die Suid - Afrikaanse Veterinere Vereniging 65:125-129, 1994.
1993 Pascoe,K.: :
Treatment of Hypoadrenocorticism in Dogs Journal of the American Veterinary Medical Association 202:1192-1193, 1993.
Pubmed reference: 8496071 .
1991 Volz,R.: :
Primary Adrenocortical Insufficiency in the Dog, Addisons Disease - A Case Report Praktische Tierarzt 72:565-568, 1991.