The detail information of Pancreatic insufficiency, exocrine
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: Pancreatic acinar atrophy

Species-specific symbol: PAA

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2013 Tsai,K.L.,Starr-Moss,A.N.,Venkataraman,G.M.,Robinson,C.,Kennedy,L.J.,Steiner,J.M.,Clark,L.A.: :
Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics 65:501-9, 2013.
Pubmed reference: 23604463 . DOI: 10.1007/s00251-013-0704-y .
2012 Clark,L.A.,Cox,M.L.: :
Current status of genetic studies of exocrine pancreatic insufficiency in dogs. Top Companion Anim Med 27:109-12, 2012.
Pubmed reference: 23148850 . DOI: 10.1053/j.tcam.2012.04.001 .
2012 German,A.J.: :
Exocrine pancreatic insufficiency in the dog: breed associations, nutritional considerations, and long-term outcome. Top Companion Anim Med 27:104-8, 2012.
Pubmed reference: 23148849 . DOI: 10.1053/j.tcam.2012.04.004 .
2012 Kennedy,O.C.,Williams,D.A.: :
Exocrine pancreatic insufficiency in dogs and cats: online support for veterinarians and owners. Top Companion Anim Med 27:117-22, 2012.
Pubmed reference: 23148852 . DOI: 10.1053/j.tcam.2012.05.001 .
2012 Tsai,K.L.,Noorai,R.E.,Starr-Moss,A.N.,Quignon,P.,Rinz,C.J.,Ostrander,E.A.,Steiner,J.M.,Murphy,K.E.,Clark,L.A.: :
Genome-wide association studies for multiple diseases of the German Shepherd Dog. Mamm Genome 23:203-11, 2012.
Pubmed reference: 22105877 . DOI: 10.1007/s00335-011-9376-9 .
2012 Westermarck,E.,Wiberg,M.: :
Exocrine pancreatic insufficiency in the dog: historical background, diagnosis, and treatment. Top Companion Anim Med 27:96-103, 2012.
Pubmed reference: 23148848 . DOI: 10.1053/j.tcam.2012.05.002 .
2010 Westermarck,E.,Saari,SA.,Wiberg,ME.: :
Heritability of Exocrine Pancreatic Insufficiency in German Shepherd Dogs. J Vet Intern Med :, 2010.
Pubmed reference: 20102502 . DOI: 10.1111/j.1939-1676.2009.0461.x .
2009 Mas,A.,Noble,PJ.,German,AJ.: :
Exocrine pancreatic insufficiency treatment study. Vet Rec 165:62, 2009.
Pubmed reference: 19596684 .
2006 Snead,E.: :
Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy. Can Vet J 47:579-82, 2006.
Pubmed reference: 16808232 .
2005 Clark,LA.,Wahl,JM.,Steiner,JM.,Zhou,W.,Ji,W.,Famula,TR.,Williams,DA.,Murphy,KE.: :
Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog. Mamm Genome 16:955-62, 2005.
Pubmed reference: 16341675 . DOI: 10.1007/s00335-005-0076-1 .
2005 Kim,JW.,Jung,DI.,Kang,BT.,Kim,HJ.,Park,C.,Park,EH.,Lim,CY.,Park,HM.: :
Canine exocrine pancreatic insufficiency treated with porcine pancreatic extract. J Vet Sci 6:263-6, 2005.
Pubmed reference: 16131834 .
2004 Bishop,MA.,Steiner,JM.,Moore,LE.,Williams,DA.: :
Evaluation of the cationic trypsinogen gene for potential mutations in miniature schnauzers with pancreatitis. Can J Vet Res 68:315-8, 2004.
Pubmed reference: 15581228 .
2004 Rutz,GM.,Steiner,JM.,Bauer,JE.,Williams,DA.: :
Effects of exchange of dietary medium chain triglycerides for long-chain triglycerides on serum biochemical variables and subjectively assessed well-being of dogs with exocrine pancreatic insufficiency. Am J Vet Res 65:1293-302, 2004.
Pubmed reference: 15478780 .
2004 Wiberg,M.E.: :
Pancreatic acinar atrophy in German shepherd dogs and rough-coated collies. Etiopathogenesis, diagnosis and treatment. A review. Vet Q 26:61-75, 2004.
Pubmed reference: 15230051 .
2003 Westermarck,E.,Wiberg,M.: :
Exocrine pancreatic insufficiency in dogs. Vet Clin North Am Small Anim Pract 33:1165-79, viii-ix, 2003.
Pubmed reference: 14552166 .
2002 Moeller,E.M.,Steiner,J.M.,Clark,L.A.,Murphy,K.E.,Famula,T.R.,Williams,D.A.,Stankovics,M.E.,Vose,A.S.: :
Inheritance of pancreatic acinar atrophy in German Shepherd Dogs American Journal of Veterinary Research 63:1429-1434, 2002.
Pubmed reference: 12371772 .
2002 Rutz,G.M.,Steiner,J.M.,Williams,D.A.: :
Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency Journal of the American Veterinary Medical Association 221:1716-+, 2002.
Pubmed reference: 12494968 .
2002 Vondrakova,K.,Klimes,J.: :
Diagnosis of exocrine pancreatic insufficiency in the dog using radial enzyme diffusion Acta Veterinaria Brno 71:223-228, 2002.
2002 Wiberg,M.E.,Westermarck,E.: :
Subclinical exocrine pancreatic insufficiency in dogs Journal of the American Veterinary Medical Association 220:1183-1187, 2002.
Pubmed reference: 11990965 .
2001 Rutz,G.M.,Steiner,J.M.,Williams,D.A.: :
Pancreatic acinar atrophy in german shepherds Compendium on Continuing Education for the Practicing Veterinarian 23:347-+, 2001.
2000 Mansfield,C.S.: :
Glucocorticoid deficiency (atypical hypoadrenocorticism) and exocrine pancreatic insufficiency in a German Shepherd Dog Australian Veterinary Practitioner 30:2-5, 2000.
2000 Rutz,G.,Steiner,J.,Hirschberger,J.: :
Exocrin pancreas insufficiency of dogs. Review article Magyar Allatorvosok Lapja 122:672-676, 2000.
1999 Rallis,T.,Adamama-Moraitou,K.K.,Soubasis,N.: :
Canine exocrine pancreatic insufficiency: Clinical and laboratory findings in 15 spontaneous cases Canine Practice 24:12-15, 1999.
1999 Wiberg,M.E.,Saari,S.A.M.,Westermarck,E.: :
Exocrine pancreatic atrophy in German Shepherd Dogs and Rough-coated Collies: An end result of lymphocytic pancreatitis Veterinary Pathology 36:530-541, 1999.
Pubmed reference: 10568434 .
1998 Wiberg,M.E.,Lautala,H.M.,Westermarck,E.: :
Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency Journal of the American Veterinary Medical Association 213:86 ff., 1998.
1997 Leidinger,E.: :
Exocrine pancreatic insufficiency in dogs and cats [German] Wiener Tierarztliche Monatsschrift 84:355-358, 1997.
1996 Spillmann,T.: :
Diagnosis of exocrine pancreatic insufficiency in dogs - advantages and disadvantages of laboratory methods for the diagnosis of chronic pancreatic diseases [German] Kleintierpraxis 41:653 ff., 1996.
1995 Westermarck,E.,Junttila,J.T.,Wiberg,M.E.: :
Role of low dietary fat in the treatment of dogs with exocrine pancreatic insufficiency American Journal of Veterinary Research 56:600-605, 1995.
Pubmed reference: 7661454 .
1994 Boari,A.,Williams,D.A.,Famiglibergamini,P.: :
Observations on Exocrine Pancreatic Insufficiency in a Family of English Setter Dogs Journal of Small Animal Practice 35:247-250, 1994.
1993 Batt,R.M.: :
Exocrine pancreatic insufficiency. Vet Clin North Am Small Anim Pract 23:595-608, 1993.
Pubmed reference: 8503162 .
1993 Westermarck,E.,Batt,R.M.,Vaillant,C.,Wiberg,M.: :
Sequential Study of Pancreatic Structure and Function During Development of Pancreatic Acinar Atrophy in a German Shepherd Dog American Journal of Veterinary Research 54:1088-1094, 1993.
Pubmed reference: 8368604 .
1991 Meister,R.,Berger,I.,Schwille,P.O.,Gebhardt,C.: :
Maximal stimulation of pancreatic islet B-cells, and A-cell response to arginine, in dogs with longterm pancreatic acinar atrophy. Eur J Surg 157:333-40, 1991.
Pubmed reference: 1678647 .
1990 Meister,R.H.,Berger,I.H.,Schwille,P.O.: :
Cholecystokinin and glucose-induced insulinaemia in dogs with and without pancreatic acinar atrophy. J Clin Chem Clin Biochem 28:379-90, 1990.
Pubmed reference: 2212955 .
1989 Raiha,M.,Westermarck,E.: :
The Signs of Pancreatic Degenerative Atrophy in Dogs and the Role of External Factors in the Etiology of the Disease Acta Veterinaria Scandinavica 30:447-452, 1989.
Pubmed reference: 2640782 .
1989 Westermarck,E.,Pamilo,P.,Wiberg,M.: :
Pancreatic Degenerative Atrophy in the Collie Breed - A Hereditary Disease Journal of Veterinary Medicine Series A-Animal Physiology Pathology and Clinical Veterinary Medicine-Zentralblatt fur Veterinarmedizin Reihe A 36:549-554, 1989.
1983 Rogers,W.A.,O'Dorisio,T.M.,Johnson,S.E.,Cataland,S.,Stradley,R.P.,Sherding,R.G.: :
Postprandial release of gastric inhibitory polypeptide (GIP) and pancreatic polypeptide in dogs with pancreatic acinar atrophy. Correction of blunted GIP response by addition of pancreatic enzymes to a meal. Dig Dis Sci 28:345-9, 1983.
Pubmed reference: 6831998 .