The detail information of Arrhythmogenic right ventricular cardiomyopathy
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: Arrhythmogenic right ventricular cardiomyopathy

Species-specific symbol: ARVC

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB48 German Boxer 58.4-63.5 cm (male), 54.6-59.7 cm (female) 29.5-36.3 kg (male), females are about 6.8 kg less than male Germany
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2015 Cattanach,B.M.,Dukes-McEwan,J.,Wotton,P.R.,Stephenson,H.M.,Hamilton,R.M.: :
A pedigree-based genetic appraisal of Boxer ARVC and the role of the Striatin mutation. Vet Rec 176:492, 2015.
Pubmed reference: 25661582 . DOI: 10.1136/vr.102821 .
2015 Sargan,D.: :
Inherited disease in boxer dogs: a cautionary tale for molecular geneticists. Vet Rec 176:490-1, 2015.
Pubmed reference: 25953873 . DOI: 10.1136/vr.h2371 .
2013 Meurs,K.M.,Stern,J.A.,Sisson,D.D.,Kittleson,M.D.,Cunningham,S.M.,Ames,M.K.,Atkins,C.E.,DeFrancesco,T.,Hodge,T.E.,Keene,B.W.,ReinaDoreste,Y.,Leuthy,M.,Motsinger-Reif,A.A.,Tou,S.P.: :
Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs. J Vet Intern Med 27:1437-40, 2013.
Pubmed reference: 24033487 . DOI: 10.1111/jvim.12163 .
2010 Hariu,C.D.,Carpenter,D.H.: :
Arrhythmogenic right ventricular cardiomyopathy in boxers. Compend Contin Educ Vet 32:E3, 2010.
Pubmed reference: 21882165 .
2010 Meurs,KM.,Mauceli,E.,Lahmers,S.,Acland,GM.,White,SN.,Lindblad-Toh,K.: :
Genome-wide association identifies a deletion in the 3' untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Hum Genet 128:315-24, 2010.
Pubmed reference: 20596727 . DOI: 10.1007/s00439-010-0855-y .
2010 Winter,RL.,Hariu,CD.,Saunders,AB.: :
ECG of the month. Arrhythmogenic right ventricular cardiomyopathy in a Boxer. J Am Vet Med Assoc 236:961-3, 2010.
Pubmed reference: 20433394 . DOI: 10.2460/javma.236.9.961 .
2009 Scansen,BA.,Meurs,KM.,Spier,AW.,Koplitz,S.,Baumwart,RD.: :
Temporal variability of ventricular arrhythmias in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 23:1020-4, 2009.
Pubmed reference: 19678888 . DOI: 10.1111/j.1939-1676.2009.0366.x .
2008 Baumwart,RD.,Meurs,KM.,Raman,SV.: :
Magnetic resonance imaging of right ventricular morphology and function in boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 23:271-4, 2008.
Pubmed reference: 19192154 . DOI: 10.1111/j.1939-1676.2008.0266.x .
2008 Oyama,MA.,Reiken,S.,Lehnart,SE.,Chittur,SV.,Meurs,KM.,Stern,J.,Marks,AR.: :
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. J Vet Cardiol 10:1-10, 2008.
Pubmed reference: 18515204 . DOI: 10.1016/j.jvc.2008.04.003 .
2007 Meurs,KM.,Ederer,MM.,Stern,JA.: :
Desmosomal gene evaluation in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am J Vet Res 68:1338-41, 2007.
Pubmed reference: 18052738 . DOI: 10.2460/ajvr.68.12.1338 .
2006 Nelson,OL.,Lahmers,S.,Schneider,T.,Thompson,P.: :
The use of an implantable cardioverter defibrillator in a Boxer Dog to control clinical signs of arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 20:1232-7, 2006.
Pubmed reference: 17063723 .
2004 Basso,C.,Fox,PR.,Meurs,KM.,Towbin,JA.,Spier,AW.,Calabrese,F.,Maron,BJ.,Thiene,G.: :
Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease. Circulation 109:1180-5, 2004.
Pubmed reference: 14993138 . DOI: 10.1161/01.CIR.0000118494.07530.65 .
1999 Meurs,K.M.,Spier,A.W.,Miller,M.W.,Lehmkuhl,L.,Towbin,J.A.: :
Familial ventricular arrhythmias in boxers Journal of Veterinary Internal Medicine 13:437-439, 1999.
Pubmed reference: 10499727 .
1995 Bright,J.M.,Mcentee,M.: :
Isolated right ventricular cardiomyopathy in a dog Journal of the American Veterinary Medical Association 207:64-66, 1995.
Pubmed reference: 7601695 .
1994 Simpson,K.W.,Bonagura,J.D.,Eaton,K.A.: :
Right Ventricular Cardiomyopathy in a Dog Journal of Veterinary Internal Medicine 8:306-309, 1994.
Pubmed reference: 7983631 .
1991 Harpster,NK.: :
Boxer cardiomyopathy. A review of the long-term benefits of antiarrhythmic therapy. Vet Clin North Am Small Anim Pract 21:989-1004, 1991.
Pubmed reference: 1949503 .