RCoV19 - Resource for Coronavirus 2019

RCoV19

A total of 817 SARS-CoV-2 sequences collected since October 2022 in mainland China have been released, covering 79 Pangolin lineages (https://ngdc.cncb.ac.cn/ncov/monitoring/country/China). One of the largest lineages is BF.7 (278, 34%), whose sequences were collected from Beijing (208, 74.8%), Shanghai (30, 10.8%) and Fujian (18, 6.5%), between October and December 2022. Sequence comparison revealed that the recent BF.7 sequences in China are completely distinct from BF.7 and its 18 sub-lineages (as of January 7, 2023). There are additional five new mutations concurrently to BF.7, namely V274L in ORF1a, L238F in ORF1b, C1243F in S, H47Y in ORF7a, and C29632T in ORF10. This suggests that there is an independent BF.7 sub-lineage spreading in China, which had also been proposed (https://github.com/cov-lineages/pango-designation/issues/1470) and has been designated as BF.7.14 recently in Pangolin.


1.	United States	5823622
2.	United Kingdom	3399086
3.	Germany	1001933
4.	Canada	843418
5.	France	813575
6.	Japan	722557
7.	Denmark	685590
8.	Spain	318188
9.	India	306010
10.	Sweden	289131
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Lineages of Concern

Alpha, B.1.1.7, Southeast England Beta, B.1.351, Nelson Mandela Bay, South African Delta, B.1.617.2, United Kingdom Epsilon, B.1.429, Southern California, USA Gamma, P.1, Brazil Omicron, BA.1, South Africa Omicron, BA.2, South Africa

Scientific Articles

核酸检测对变异后的新冠病毒是否还灵敏？新冠是否有“特效药”？新冠病毒在英国、南非、巴西、乌干达等国的变异情况变异是否会影响新冠疫苗的功效? 动物与新冠病毒

NCBI SARS-CoV-2 Resources EBI COVID-19 Data Portal GISAID NMDC

LitCovid EuropePMC Elsevier medRxiv and bioRxiv

Coronaviruses COVID-19 SARS Coronavirus MERS Coronavirus

China CDC World Health Organization (WHO) US CDC Johns Hopkins University

Li C, Ma L, Zou D, et al. RCoV19: A One-stop Hub for SARS-CoV-2 Genome Data Integration, Variant Monitoring, and Risk Pre-warning. Genomics, Proteomics & Bioinformatics, 2023.https://doi.org/10.1016/j.gpb.2023.10.004. [OLB-PM-37898309]

Song S, Ma L, Zou D, Tian D, Li C, Zhu J, et al. The global landscape of SARS-CoV-2 genomes, variants, and haplotypes in 2019nCoVR. Genomics, Proteomics & Bioinformatics, 2020.https://doi.org/10.1016/j.gpb.2020.09.001. [OLB-PM-33704069]

Gong Z, Zhu J, Li C, Jiang S, Ma L, Tang B, Zou D, Chen M, Sun Y, Song S, Zhang Z, Xiao J, Xue Y, Bao Y, Du Z, Zhao WM: A coronavirus online analysis platform at the National Genomics Data Center. Zoological Research 2020, doi: 10.24272/j.issn.2095-8137.2020.065. [OLB-PM-33704069]

Zhao WM, Song SH, Chen ML, et al. The 2019 novel coronavirus resource. Yi Chuan. 2020;42(2):212–221. doi:10.16288/j.yczz.20-030 [[OLB-PM-32102777]

Note: Complete genome sequences used for analyses within this resource were obtained from the CNGBdb, GenBank, GISAID, GWH and NMDC databases. We acknowledge the sample providers and data submitters listed on the Released SARS-CoV-2 genome sequences page.