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The Journal of infectious diseases
Apr 01, 2017;215 (7): 1107-1110.

Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses.

Tao Jiang, Jia-Fu Jiang, Yong-Qiang Deng, Bao-Gui Jiang, Hang Fan, Jian-Feng Han, Yi Hu, Dao-Min Zhuang, David Kargbo, Xiao-Ping An, Zhi-Qiang Mi, Guang-Yu Zhao, Wen-Wen Xin, Ya-Fang Tan, Jun He, Rong-Bao Gao, Hong Wang, Cao Chen, Feng Wang, Chun-Xiao Li, Jian-Jun Zhao, Yu-Jun Cui, Zhu-Chun Bei, Ke Zhang, Xue-Yi Shang, Wen-Hui Zhang, Guang-Qian Pei, Yun-Fei Wang, Wei Wang, Peng Shu, Wen-Li Liu, Shi Cheng, Shun-Ya Zhu, Alex Kanu, Brima Kargbo, Bo Gao, Yi-Gang Tong, Tong-Yu Fang, Wu-Chun Cao
Author Information
  1. Tao Jiang: State Key Laboratory of Pathogen and Biosecurity.
  2. Jia-Fu Jiang: State Key Laboratory of Pathogen and Biosecurity.
  3. Yong-Qiang Deng: State Key Laboratory of Pathogen and Biosecurity.
  4. Bao-Gui Jiang: State Key Laboratory of Pathogen and Biosecurity.
  5. Hang Fan: State Key Laboratory of Pathogen and Biosecurity.
  6. Jian-Feng Han: State Key Laboratory of Pathogen and Biosecurity.
  7. Yi Hu: State Key Laboratory of Pathogen and Biosecurity.
  8. Dao-Min Zhuang: State Key Laboratory of Pathogen and Biosecurity.
  9. David Kargbo: Ministry of Health and Sanitation, and.
  10. Xiao-Ping An: State Key Laboratory of Pathogen and Biosecurity.
  11. Zhi-Qiang Mi: State Key Laboratory of Pathogen and Biosecurity.
  12. Guang-Yu Zhao: State Key Laboratory of Pathogen and Biosecurity.
  13. Wen-Wen Xin: State Key Laboratory of Pathogen and Biosecurity.
  14. Ya-Fang Tan: State Key Laboratory of Pathogen and Biosecurity.
  15. Jun He: State Key Laboratory of Pathogen and Biosecurity.
  16. Rong-Bao Gao: National Institute for Viral Disease Control and Prevention, and.
  17. Hong Wang: National Institute for Viral Disease Control and Prevention, and.
  18. Cao Chen: National Institute for Viral Disease Control and Prevention, and.
  19. Feng Wang: National Institute for Viral Disease Control and Prevention, and.
  20. Chun-Xiao Li: State Key Laboratory of Pathogen and Biosecurity.
  21. Jian-Jun Zhao: State Key Laboratory of Pathogen and Biosecurity.
  22. Yu-Jun Cui: State Key Laboratory of Pathogen and Biosecurity.
  23. Zhu-Chun Bei: State Key Laboratory of Pathogen and Biosecurity.
  24. Ke Zhang: State Key Laboratory of Pathogen and Biosecurity.
  25. Xue-Yi Shang: Hospital No 307, Beijing, China; and.
  26. Wen-Hui Zhang: State Key Laboratory of Pathogen and Biosecurity.
  27. Guang-Qian Pei: State Key Laboratory of Pathogen and Biosecurity.
  28. Yun-Fei Wang: State Key Laboratory of Pathogen and Biosecurity.
  29. Wei Wang: State Key Laboratory of Pathogen and Biosecurity.
  30. Peng Shu: State Key Laboratory of Pathogen and Biosecurity.
  31. Wen-Li Liu: State Key Laboratory of Pathogen and Biosecurity.
  32. Shi Cheng: State Key Laboratory of Pathogen and Biosecurity.
  33. Shun-Ya Zhu: State Key Laboratory of Pathogen and Biosecurity.
  34. Alex Kanu: Sierra Leone-China Friendship Hospital, Freetown, Sierra Leone.
  35. Brima Kargbo: Ministry of Health and Sanitation, and.
  36. Bo Gao: State Key Laboratory of Pathogen and Biosecurity.
  37. Yi-Gang Tong: State Key Laboratory of Pathogen and Biosecurity.
  38. Tong-Yu Fang: State Key Laboratory of Pathogen and Biosecurity.
  39. Wu-Chun Cao: State Key Laboratory of Pathogen and Biosecurity.
PMID: 28498995 DOI: 10.1093/infdis/jix061

Abstract

We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate.

Keywords

Sierra Leone clinical features ebola virus disease evolutionary analyses. immunological characteristics

MeSH Term

Antibodies, Viral
Cytokines
Disease Outbreaks
Ebolavirus
Genome, Viral
Hemorrhagic Fever, Ebola
Humans
Sierra Leone
Survivors
Viral Load

Chemicals

Antibodies, Viral
Cytokines
Journal Article
Article has an altmetric score of 1

Word Cloud

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