The detail information of Amyloidosis
Basic Information

Disease Ontology ID: DDTO:0000335

Disease Description: A condition where abnormal deposits of proteinaceous material called amyloid are laid down in tissues and impair their function. Common in Akitas and Chinese shar peis.

Inherit Mode: -

Disease Symptom: -

Disease Cause: -

Disease Diagnose: Because of its wide distribution and stealthy onset, amyloidosis is difficult to diagnose. However, your veterinarian may suspect amyloidosis if your dog has a chronic infection or inflammation and develops kidney or liver failure. Renal biopsies are needed to differentiate renal amyloidosis from immune complex-mediated glomerulonephritis(ICGN).

Treat Method: There is no proven specific treatment for amyloidosis. Treatment of the underlying disease may result in regression of amyloid and associated signs. The prognosis is usually poor. Some dogs can be managed up to 1 year.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Amyloidosis - - -
Amyloidosis, AA - - -
Amyloidosis, renal - - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB25 Bearded Collie Bouncy, charismatic, friendly; smart, but also stubborn and independent 53.3-55.9 cm (male), 50.8-53.3 cm (female) 20.4-24.9 kg United Kingdom (Scotland)
Associated Disease Variants from OMIA
Gene Differential Expression
References
2017 Jäkel,L.,VanNostrand,W.E.,Nicoll,J.A.R.,Werring,D.J.,Verbeek,M.M.: :
Animal models of cerebral amyloid angiopathy. Clin Sci (Lond) 131:2469-2488, 2017.
Pubmed reference: 28963121 . DOI: 10.1042/CS20170033 .
2013 Olsson,M.,Tintle,L.,Kierczak,M.,Perloski,M.,Tonomura,N.,Lundquist,A.,Murén,E.,Fels,M.,Tengvall,K.,Pielberg,G.,DufauredeCitres,C.,Dorso,L.,Abadie,J.,Hanson,J.,Thomas,A.,Leegwater,P.,Hedhammar,A.,Lindblad-Toh,K.,Meadows,J.R.: :
Thorough Investigation of a Canine Autoinflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis. PLoS One 8:e75242, 2013.
Pubmed reference: 24130694 . DOI: 10.1371/journal.pone.0075242 .
2012 Segev,G.,Cowgill,L.D.,Jessen,S.,Berkowitz,A.,Mohr,C.F.,Aroch,I.: :
Renal Amyloidosis in Dogs: A Retrospective Study of 91 Cases with Comparison of the Disease between Shar-Pei and Non-Shar-Pei Dogs. J Vet Intern Med :, 2012.
Pubmed reference: 22268374 . DOI: 10.1111/j.1939-1676.2011.00878.x .
2012 Segev,G.,Cowgill,L.D.,Jessen,S.,Berkowitz,A.,Mohr,C.F.,Aroch,I.: :
Renal Amyloidosis in Dogs: A Retrospective Study of 91 Cases with Comparison of the Disease between Shar-Pei and Non-Shar-Pei Dogs. J Vet Intern Med :, 2012.
Pubmed reference: 22268374 . DOI: 10.1111/j.1939-1676.2011.00878.x .
1999 Jull,B.: :
Pulmonary thrombosis and glomerular amyloidosis in a dog Veterinary Medicine 94:686-687, 1999.
1998 Venco,L.,Calzolari,D.,Morini,S.: :
Pulmonary thromboembolism in a dog with renal amyloidosis Veterinary Radiology & Ultrasound 39:564-565, 1998.
Pubmed reference: 9845198 .
1998 Dubuis,J.C.,Schmid,V.,Boujon,P.: :
Two cases of renal amyloidosis of the Shar Pei [German] Schweizer Archiv fur Tierheilkunde 140:156-160, 1998.
Pubmed reference: 9581494 .
1996 Vial,V.,Cotard,J.P.: :
Renal amyloidosis in a Jagd terrier [French] Recueil de Medecine Veterinaire 172:329-334, 1996.
1996 Mason,N.J.,Day,M.J.: :
Renal amyloidosis in related english foxhounds Journal of Small Animal Practice 37:255-260, 1996.
Pubmed reference: 8805095 .
1996 Cook,A.K.,Cowgill,L.D.: :
Clinical and pathological features of protein-losing glomerular disease in the dog - a review of 137 cases (1985-1992) Journal of the American Animal Hospital Association 32:313-322, 1996.
Pubmed reference: 8784722 .
1996 Gruys,E.: :
Inflammatory syndrome of footpads in puppies and AA-amyloidosis Veterinary Record 138:264, 1996.
Pubmed reference: 8734514 .
1995 Johnson,K.H.,Sletten,K.,Hayden,D.W.,Obrien,T.D.,Rossow,K.D.,Westermark,P.: :
AA amyloidosis in Chinese Shar-pei dogs: Immunohistochemical and amino acid sequence analyses Amyloid - International Journal of Experimental and Clinical Investigation 2:92-99, 1995.
1995 Johnson,K.H.,Sletten,K.,Hayden,D.W.,Obrien,T.D.,Rossow,K.D.,Westermark,P.: :
AA amyloidosis in Chinese Shar-Pei dogs - immunohistochemical and amino acid sequence analyses (vol 2, pg 92, 1995) Amyloid-International Journal of Experimental & Clinical Investigation 2:293, 1995.
1994 Gelens,H.C.,Vanderlindesipman,J.S.,Vanederen,A.M.,Ultee,A.,Alsemgeest,S.P.M.,Gruys,E.: :
Reactive amyloidosis in a puppy, associated with a chronic inflammatory syndrome Journal of the American Animal Hospital Association 30:529-532, 1994.
1994 Loeven,K.O.: :
Spontaneous hepatic rupture secondary to amyloidosis in a Chinese shar pei Journal of the American Animal Hospital Association 30:577-579, 1994.
1994 Loeven,K.O.: :
Hepatic Amyloidosis in 2 Chinese Shar-Pei Dogs Journal of the American Veterinary Medical Association 204:1212-1216, 1994.
Pubmed reference: 8014090 .
1993 Rivas,A.L.,Tintle,L.,Meyers-Wallen,V.N.,Scarlett,J.M.,Vantassell,C.P.,Quimby,F.W.: :
Inheritance of Renal Amyloidosis in Chinese Shar-Pei Dogs Journal of Heredity 84:438-442, 1993.
Pubmed reference: 8270767 .
1992 Johnson,K.H.,Sletten,K.,Hayden,D.W.,Obrien,T.D.,Roertgen,K.E.,Westermark,P.: :
Pulmonary Vascular Amyloidosis in Aged Dogs - A New Form of Spontaneously Occurring Amyloidosis Derived from Apolipoprotein AI American Journal of Pathology 141:1013-1019, 1992.
Pubmed reference: 1443041 .
1992 Bowles,M.H.,Mosier,D.A.: :
Renal Amyloidosis in a Family of Beagles Journal of the American Veterinary Medical Association 201:569-574, 1992.
Pubmed reference: 1517131 .
1992 Hansen,P.: :
Renal Amyloidosis in the Dog and Cat - Pathophysiology, Symptoms, Diagnosis and Treatment Annales de Medecine Veterinaire 136:171-178, 1992.
1990 Dibartola,S.P.,Tarr,M.J.,Webb,D.M.,Giger,U.: :
Familial Renal Amyloidosis in Chinese Shar-Pei Dogs Journal of the American Veterinary Medical Association 197:483-487, 1990.
Pubmed reference: 2211293 .