The detail information of Narcolepsy
Basic Information

Disease Ontology ID: DDTO:0000348

Disease Description: A neurological disorder characterized by falling asleep suddenly (collapse) which can occur during periods of activity and last for varying lengths of time. Seen in Doberman pinschers and Labrador retrievers.

Inherit Mode: -

Disease Symptom: In a narcoleptic episode, an animal may abruptly lose consciousness, fall on its side or stomach, and lie perfectly still, as if napping. Like in deep sleep, rapid closed eye movements (REM) may occur and muscles become slack, but the dog may still be aware of his surroundings. Often, the dog will abruptly come out of an episode after auditory or physical stimulation.

Disease Cause: Certain factors predispose a dog to narcolepsy. Dogs that are obese, inactive, or have immune system variations are more likely to be narcoleptic. There is also a heritable component to narcolepsy. Researchers have identified an inherited form of the disease in Doberman Pinschers, caused by a genetic defect involving a chemical neurotransmitter called hypocretin. Abnormalities in hypocretin receptors interrupt the regulation of normal sleep cycles. Abnormalities in hypocretin receptors in other dogs such as Labrador Retrievers, Poodles, and Dachshunds have also been identified.

Disease Diagnose: Narcolepsy is usually identified based on the symptoms alone, so a thorough history of your dog’s behavior and a detailed description of the attacks are critical. If you can film an incident, that’s even better. Since narcoleptic symptoms also occur with other medical problems, conditions such as heart disease, diabetes, and epilepsy must be ruled out. To arrive at an accurate diagnosis, your veterinarian will perform physical and neurologic exams, which are usually normal. Laboratory tests, including a blood chemical profile, a complete blood count, a urinalysis, and an electrolyte panel, will help rule out any underlying diseases.

Treat Method: There is no definitive cure for narcolepsy, but help is still available for affected dogs

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Narcolepsy - Autosomal Recessive -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB2 Afghan Hound Independent, sweet, silly 63.5-68.6 cm 22.7-27.2 kg Afghanistan
CB3 Airedale Terrier Clever, confident, proud; friendly but courageous 58.4 cm 22.7-31.8 kg United Kingdom (England)
CB5 Alaskan Malamute Affectionate, loyal, playful but dignified 63.5 cm (male), 58.4 cm (female) 38.6 kg (male), 34 kg (female) United States
CB89 Dogo Argentino Loyal, trustworthy,courageous 61-68.6 cm (male), 59.7-66 cm (female) 36.3-45.4 kg Argentina
CB98 English Toy Spaniel Affectionate, Alert, Merry 22.9-25.4 cm 3.6-6.4 kg England
CB132 Irish Terrier Bold, dashing, even reckless; stouthearted at work, tenderhearted at home 45.7 cm 12.2 kg (male), 11.3 kg (female) Ireland
CB148 Lagotto Romagnolo(Romagna Water Dog) Easygoing, affectionate, and eager to please 43.2-48.3 cm (male), 40.6-45.7 cm (female) 12.9-15.9 kg (male), 10.9-14.1 kg (female) Italy
CB259 Wire-Haired Vizsla Calm and gentle around the house; an exuberant hunter on land or lake 57.8-64.1 cm (male), 54-59.7 cm (female) 24.9-29.5 kg (male), 20.4-24.9 kg (female) Hungary
Associated Disease Variants from OMIA
Gene Differential Expression
References
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2001 Nishino,S.,Fujiki,N.,Ripley,B.,Sakurai,E.,Kato,M.,Watanabe,T.,Mignot,E.,Yanai,K.: :
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1999 Ostrander,E.A.,Giniger,E.: :
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1999 Faraco,J.,Lin,X.,Li,R.,Hinton,L.,Lin,L.,Mignot,E.: :
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1999 Coleman,E.S.: :
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1999 Lin,L.,Faraco,J.,Li,R.,Kadotani,H.,Rogers,W.,Lin,X.Y.,Qiu,X.H.,de,Jong,P.J.,Nishino,S.,Mignot,E.: :
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1998 Cederberg,R.,Nishino,S.,Dement,W.C.,Mignot,E.: :
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1997 Honda,K.,Riehl,J.,Inoue,S.,Mignot,E.,Nishino,S.: :
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1997 Nishino,S.,Arrigoni,J.,Shelton,J.,Kanbayashi,T.,Dement,W.C.,Mignot,E.: :
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1997 Nishino,S.,Mignot,E.: :
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1997 Nishino,S.,Tafti,M.,Sampathkumaran,R.,Dement,W.C.,Mignot,E.: :
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1997 Tafti,M.,Nishino,S.,Liao,W.,Dement,W.C.,Mignot,E.: :
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1996 Kanbayashi,T.,Nishino,S.,Tafti,M.,Hishikawa,Y.,Dement,W.C.,Mignot,E.: :
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1996 Tafti,M.,Nishino,S.,Aldrich,M.S.,Liao,W.N.,Dement,W.C.,Mignot,E.: :
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1996 Reid,M.S.,Tafti,M.,Nishino,S.,Sampathkumaran,R.,Siegel,J.M.,Mignot,E.: :
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1995 Nishino,S.,Tafti,M.,Reid,M.S.,Shelton,J.,Siegel,J.M.,Dement,W.C.,Mignot,E.: :
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1995 Nitz,D.,Andersen,A.,Fahringer,H.,Nienhuis,R.,Mignot,E.,Siegel,J.: :
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1995 Shelton,J.,Nishino,S.,Vaught,J.,Dement,W.C.,Mignot,E.: :
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1994 Reid,M.S.,Tafti,M.,Nishino,S.,Siegel,J.M.,Dement,W.C.,Mignot,E.: :
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1994 Reid,M.S.,Tafti,M.,Geary,J.N.,Nishino,S.,Siegel,J.M.,Dement,W.C.,Mignot,E.: :
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1994 Mignot,E.,Bell,R.A.,Rattazzi,C.,Lovett,M.,Grumet,F.C.,Dement,W.C.: :
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1994 Nishino,S.,Reid,M.S.,Dement,W.C.,Mignot,E.: :
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1993 Mignot,E.J.M.,Dement,W.C.: :
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1993 Mignot,E.,Nishino,S.,Sharp,L.H.,Arrigoni,J.,Siegel,J.M.,Reid,M.S.,Edgar,D.M.,Ciaranello,R.D.,Dement,W.C.: :
Heterozygosity at the canarc-1 Locus Can Confer Susceptibility for Narcolepsy - Induction of Cataplexy in Heterozygous Asymptomatic Dogs After Administration of a Combination of Drugs Acting on Monoaminergic and Cholinergic Systems Journal of Neuroscience 13:1057-1064, 1993.
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1993 Nishino,S.,Fruhstorfer,B.,Arrigoni,J.,Guilleminault,C.,Dement,W.C.,Mignot,E.: :
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1992 Nishino,S.,Arrigoni,J.,Sharp,L.H.,Shelton,J.D.,Dement,W.C.,Mignot,E.: :
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1992 Valtier,D.,Dement,W.C.,Mignot,E.: :
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1991 Kornberg,M.,Kornberg,L.,Blanke,E.,Wagner,V.,Dahme,E.: :
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1991 Renaud,A.,Nishino,S.,Dement,W.C.,Guilleminault,C.,Mignot,E.: :
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1990 Miller,J.D.,Faull,K.F.,Bowersox,S.S.,Dement,W.C.: :
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1989 Motoyama,M.,Kilduff,T.S.,Lee,B.S.M.,Dement,W.C.,Mcdevitt,H.O.: :
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1989 Vanheerden,J.,Eckersley,G.N.: :
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1989 Fruhstorfer,B.,Mignot,E.,Bowersox,S.,Nishino,S.,Dement,W.C.,Guilleminault,C.: :
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1987 Bowersox,S.S.,Kilduff,T.S.,Faull,K.F.,Zeller-DeAmicis,L.,Dement,W.C.,Ciaranello,R.D.: :
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1984 Boehme,R.E.,Baker,T.L.,Mefford,I.N.,Barchas,J.D.,Dement,W.C.,Ciaranello,R.D.: :
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1977 Mitler,M.M.,Dement,W.C.: :
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1974 Mitler,M.M.,Boysen,B.G.,Campbell,L.,Dement,W.C.: :
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