The detail information of Histiocytosis
Basic Information

Disease Ontology ID: DDTO:0000454

Disease Description: Histiocytic syndromes are a complex group of disorders which overlap.

Inherit Mode: The disorder has a polygenic mode of inheritance in the Bernese mountain dog. The disorder is also more common in the other breeds listed below.

Disease Symptom: In both systemic and malignant histiocytosis, signs of illness include loss of appetite, weight loss, and lethargy. In systemic histiocytosis, there are skin lesions (crusting, firm nodules, ulcers) but these are uncommon in malignant histiocytosis. Both affect middle-aged to older dogs, while cutaneous histiocytosis occurs in younger dogs.There may be periods of remission with systemic histiocytosis, but ultimately the histiocytes infiltrate other organ systems especially the lungs, liver, spleen, bone marrow, and lymph nodes. Malignant histiocytosis is a rapidly progressive and invasive disorder, which commonly metastasizes to the lungs.

Disease Cause: -

Disease Diagnose: The clinical signs of this disorder vary depending on where metastasis of abnormal cells occurs. Tumours in the lungs are common, causing respiratory signs such as coughing and shortness of breath. Your veterinarian will likely suspect a tumour based on clinical signs, radiology, and blood tests; he or she will submit tissue samples to a pathologist for histopathologic examination to determine the type of tumour.

Treat Method: Malignant histiocytosis spreads rapidly and metastasis is generally present at the time of diagnosis, so that surgical treatment is ineffective. Dogs with systemic histiocytosis may experience periods of remission, or the disease may progress rapidly. Various types of chemotherapy have been tried for both types of histiocytosis, but with little success.Your veterinarian will work with you to keep your dog as comfortable as possible, until the quality of life deteriorates to the point where euthanasia is the best treatment option.

Breeder Advice: Because this invariably fatal disorder generally does not develop until the dog is middle-aged or older, it can be hard to identify parents that carry the trait. It is very important that the veterinarian and/or owner inform the breeder when this disorder has been diagnosed, so that he or she can modify the breeding programme accordingly, to limit the spread of the harmful gene(s) in the Bernese mountain dog population.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Histiocytosis, malignant - Multifactorial - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB34 Bernese Mountain Dog Good-natured and calm. 63.5-71.1 cm (male), 58.4-66 cm (female) 39-49.9 kg (male), 35.8-49.9 kg (female) Switzerland
CB105 Flat-Coated Retriever Happy, confident, intelligent, and forever young 58.4-62.2 cm (male), 55.9-59.7 cm (female) 27.2-31.8 kg United Kingdom
CB116 Golden Retriever Intelligent, friendly, and devoted. 58.4-61 cm (male), 54.6-57.2 cm (female) 29.5-34 kg (male), 24.9-29.5 kg (female) United Kingdom (Scotland)
CB205 Rottweiler Reserved with strangers and affectionate and loyal with his family. 61-68.6 cm (male), 55.9-63.5 cm (female) 49.9-59 kg (male), 34.9-49.9 kg (female) Germany
Associated Disease Variants from OMIA
Gene Differential Expression
References
2021 Evans,J.M.,Parker,H.G.,Rutteman,G.R.,Plassais,J.,Grinwis,G.C.M.,Harris,A.C.,Lana,S.E.,Ostrander,E.A.: :
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2019 Kennedy,K.,Thomas,R.,Durrant,J.,Jiang,T.,Motsinger-Reif,A.,Breen,M.: :
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2015 Mariani,C.L.,Jennings,M.K.,Olby,N.J.,Borst,L.B.,Brown,J.C.,Robertson,I.D.,Seiler,G.S.,MacKillop,E.: :
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2015 Heinrich,F.,Contioso,V.B.,Stein,V.M.,Carlson,R.,Tipold,A.,Ulrich,R.,Puff,C.,Baumgärtner,W.,Spitzbarth,I.: :
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2014 VanderHart,D.J.,Reese,D.J.,Greenberg,S.M.: :
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2014 Barrett,L.E.,Pollard,R.E.,Zwingenberger,A.,Zierenberg-Ripoll,A.,Skorupski,K.A.: :
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2014 Boerkamp,K.M.,vanSteenbeek,F.G.,Penning,L.C.,GrootKoerkamp,M.J.,vanLeenen,D.,Vos-Loohuis,M.,Grinwis,G.C.,Rutteman,G.R.: :
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2014 Chikazawa,S.,Kitahara,Y.,Ando,E.,Hori,Y.,Hoshi,F.,Kanai,K.,Ito,N.,Higuchi,S.: :
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2014 Davis,B.W.,Ostrander,E.A.: :
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2014 Denstedt,E.: :
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2014 Takahashi,M.,Tomiyasu,H.,Hotta,E.,Asada,H.,Fukushima,K.,Kanemoto,H.,Fujino,Y.,Ohno,K.,Uchida,K.,Nakayama,H.,Tsujimoto,H.: :
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2014 Empl,M.T.,Macke,S.,Winterhalter,P.,Puff,C.,Lapp,S.,Stoica,G.,Baumgärtner,W.,Steinberg,P.: :
The growth of the canine glioblastoma cell line D-GBM and the canine histiocytic sarcoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin. Vet Comp Oncol 12:149-59, 2014.
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2014 Moore,P.F.: :
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2013 Boerkamp,K.M.,vanderKooij,M.,vanSteenbeek,F.G.,vanWolferen,M.E.,GrootKoerkamp,M.J.,vanLeenen,D.,Grinwis,G.C.,Penning,L.C.,Wiemer,E.A.,Rutteman,G.R.: :
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2013 Dobson,J.M.: :
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2013 Erich,S.A.,Rutteman,G.R.,Teske,E.: :
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2013 Ito,K.,Kuroki,S.,Kobayashi,M.,Ono,K.,Washizu,T.,Bonkobara,M.: :
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2013 NikolicNielsen,L.,Kjelgaard-Hansen,M.,Kristensen,A.T.: :
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2013 Silva,G.,Fachin,A.L.,Beleboni,R.O.,França,S.C.,Marins,M.: :
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2013 Thakkar,P.,Pease,A.P.,Guiot,L.P.,Fitzgerald,S.D.,AduAddai,B.,Smedley,R.C.: :
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2013 Yamazaki,H.,Takagi,S.,Hoshino,Y.,Hosoya,K.,Okumura,M.: :
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2013 Yamazaki,H.,Takagi,S.,Oh,N.,Hoshino,Y.,Hosoya,K.,Okumura,M.: :
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2013 vanKuijk,L.,vanGinkel,K.,deVos,J.P.,Brearley,M.J.,Butinar,J.,Gielen,I.,vanGarderen,E.,Chiers,K.,Verhoeven,P.S.: :
Peri-articular histiocytic sarcoma and previous joint disease in Bernese Mountain Dogs. J Vet Intern Med 27:293-9, 2013.
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2012 Sapierzyński,R.,Jagielski,D.,Dolka,I.,Fabisiak,M.: :
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2012 Nielsen,L.N.,McEvoy,F.,Jessen,L.R.,Kristensen,A.T.: :
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2012 Tsai,S.,Sutherland-Smith,J.,Burgess,K.,Ruthazer,R.,Sato,A.: :
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2012 Shearin,A.L.,Hedan,B.,Cadieu,E.,Erich,S.A.,Schmidt,E.V.,Faden,D.L.,Cullen,J.,Abadie,J.,Kwon,E.M.,Gröne,A.,Devauchelle,P.,Rimbault,M.,Karyadi,D.M.,Lynch,M.,Galibert,F.,Breen,M.,Rutteman,G.R.,André,C.,Parker,H.G.,Ostrander,E.A.: :
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2012 Tsai,P.C.,Breen,M.: :
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2012 Mastrorilli,C.,Spangler,E.A.,Christopherson,P.W.,Aubry,O.A.,Newton,J.C.,Smith,A.N.,Kennis,R.A.,Weismann,J.L.,Moore,P.F.: :
Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping. Vet Clin Pathol 41:412-8, 2012.
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2012 Hafeman,S.D.,Varland,D.,Dow,S.W.: :
Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Vet Comp Oncol 10:44-56, 2012.
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2012 Arnold,E.J.,Pressler,B.M.,Heng,H.G.: :
What is your diagnosis? Histiocytic sarcoma. J Am Vet Med Assoc 240:821-3, 2012.
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2011 Sterenczak,K.A.,Kleinschmidt,S.,Wefstaedt,P.,Eberle,N.,Hewicker-Trautwein,M.,Bullerdiek,J.,Nolte,I.,MuruaEscobar,H.: :
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2011 Klahn,S.L.,Kitchell,B.E.,Dervisis,N.G.: :
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2011 Soare,T.,Noble,P.J.,Hetzel,U.,Fonfara,S.,Kipar,A.: :
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2011 Hedan,B.,Thomas,R.,Motsinger-Reif,A.,Abadie,J.,Andre,C.,Cullen,J.,Breen,M.: :
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer 11:201, 2011.
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2011 Constantino-Casas,F.,Mayhew,D.,Hoather,T.M.,Dobson,J.M.: :
The clinical presentation and histopathologic-immunohistochemical classification of histiocytic sarcomas in the Flat Coated Retriever. Vet Pathol 48:764-71, 2011.
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2010 Rassnick,K.M.,Moore,A.S.,Russell,D.S.,Northrup,N.C.,Kristal,O.,Bailey,D.B.,Flory,A.B.,Kiselow,M.A.,Intile,J.L.: :
Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. J Vet Intern Med 24:1528-31, 2010.
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2010 Friedrichs,K.R.,Thomas,C.,Plier,M.,Andrews,G.A.,Chavey,P.S.,Young,K.M.: :
Evaluation of serum ferritin as a tumor marker for canine histiocytic sarcoma. J Vet Intern Med 24:904-11, 2010.
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2010 Hafeman,S.,London,C.,Elmslie,R.,Dow,S.: :
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2010 Nielsen,L.,Andreasen,SN.,Andersen,SD.,Kristensen,AT.: :
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2010 Castellanos,V.C.,O'Neill,S.,Seiler,G.S.: :
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2010 André,C.,Abadie,J.,Hedan,B.,deBrito,C.,Lagadic,M.,Poujade,A.,Devauchelle,P.: :
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2009 Abadie,J.,Hédan,B.,Cadieu,E.,DeBrito,C.,Devauchelle,P.,Bourgain,C.,Parker,H.G.,Vaysse,A.,Margaritte-Jeannin,P.,Galibert,F.,Ostrander,E.A.,André,C.: :
Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered 100 Suppl 1:S19-27, 2009.
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2009 Maruo,T.,Namikawa,K.,Kunihiro,A.,Lynch,J.,Shida,T.,Kishikawa,S.: :
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2009 Wagter,H.W.,Vos,A.J.,vandenIngh,T.: :
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2007 Schultz,R.M.,Puchalski,S.M.,Kent,M.,Moore,P.F.: :
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2006 Soller,J.T.,MuruaEscobar,H.,Janssen,M.,Fork,M.,Bullerdiek,J.,Nolte,I.: :
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