Disease Ontology ID: DDTO:0000690
Abbreviated Name: ARVC
Disease Description: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disease in the Boxer dog and has also been called Boxer Cardiomyopathy; rarely other breeds are affected. This disease most commonly causes heart arrhythmias that can result in episodes of collapse or fainting and even sudden death.
Inherit Mode: -
Disease Symptom: The most common symptoms of ARVC are episodes of collapse or fainting, this is called syncope. Some dogs will die suddenly and this may be preceded by episodes of syncope or this could be the first symptom of the disease. A small proportion of dogs will develop heart muscle failure that could lead to signs that include shortness of breath, coughing, exercise intolerance and difficulty resting comfortably. Some dogs have no symptoms of the disease and it is identified incidentally.
Disease Cause: A genetic deletion in an important heart gene (striatin) has been identified in Boxers and it seems that up to 40% of Boxers have this genetic mutation.
Disease Diagnose: Patients suspected of having ARVC should have a thorough physical examination and diagnostic procedures including an electrocardiogram (ECG), blood pressure measurement and an ultrasound of the heart (echocardiogram). In order to best evaluate the severity of the heart arrhythmia most dogs will have a Holter monitor performed. A Holter monitor is a 24 hour ECG that is worn at home and allows the cardiologist to evaluate the heart rate and rhythm during normal activity. This is also performed to evaluate the efficacy of treatment.
Treat Method: The treatment for ARVC will depend on the severity of the arrhythmia and other findings from diagnostic testing. If the patient has severe arrhythmias then a medication called an antiarrhythmic may be recommended with the goal of controlling or improving the arrhythmia. This type of treatment requires monitoring to ensure that it is being effective and the treatment may be changed depending on that particular patient’s response.
Breeder Advice: -
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Arrhythmogenic right ventricular cardiomyopathy | Arrhythmogenic right ventricular cardiomyopathy | Multifactorial | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB48 | German Boxer | Fun-loving, bright, active and loyal | 58.4-63.5 cm (male), 54.6-59.7 cm (female) | 29.5-36.3 kg (male), females are about 6.8 kg less than male | Germany |
| 2015 |
Cattanach,B.M.,Dukes-McEwan,J.,Wotton,P.R.,Stephenson,H.M.,Hamilton,R.M.: :
A pedigree-based genetic appraisal of Boxer ARVC and the role of the Striatin mutation. Vet Rec 176:492, 2015. Pubmed reference: 25661582 . DOI: 10.1136/vr.102821 . |
| 2015 |
Sargan,D.: :
Inherited disease in boxer dogs: a cautionary tale for molecular geneticists. Vet Rec 176:490-1, 2015. Pubmed reference: 25953873 . DOI: 10.1136/vr.h2371 . |
| 2013 |
Meurs,K.M.,Stern,J.A.,Sisson,D.D.,Kittleson,M.D.,Cunningham,S.M.,Ames,M.K.,Atkins,C.E.,DeFrancesco,T.,Hodge,T.E.,Keene,B.W.,ReinaDoreste,Y.,Leuthy,M.,Motsinger-Reif,A.A.,Tou,S.P.: :
Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs. J Vet Intern Med 27:1437-40, 2013. Pubmed reference: 24033487 . DOI: 10.1111/jvim.12163 . |
| 2010 |
Hariu,C.D.,Carpenter,D.H.: :
Arrhythmogenic right ventricular cardiomyopathy in boxers. Compend Contin Educ Vet 32:E3, 2010. Pubmed reference: 21882165 . |
| 2010 |
Meurs,KM.,Mauceli,E.,Lahmers,S.,Acland,GM.,White,SN.,Lindblad-Toh,K.: :
Genome-wide association identifies a deletion in the 3' untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Hum Genet 128:315-24, 2010. Pubmed reference: 20596727 . DOI: 10.1007/s00439-010-0855-y . |
| 2010 |
Winter,RL.,Hariu,CD.,Saunders,AB.: :
ECG of the month. Arrhythmogenic right ventricular cardiomyopathy in a Boxer. J Am Vet Med Assoc 236:961-3, 2010. Pubmed reference: 20433394 . DOI: 10.2460/javma.236.9.961 . |
| 2009 |
Scansen,BA.,Meurs,KM.,Spier,AW.,Koplitz,S.,Baumwart,RD.: :
Temporal variability of ventricular arrhythmias in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 23:1020-4, 2009. Pubmed reference: 19678888 . DOI: 10.1111/j.1939-1676.2009.0366.x . |
| 2008 |
Baumwart,RD.,Meurs,KM.,Raman,SV.: :
Magnetic resonance imaging of right ventricular morphology and function in boxer dogs with arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 23:271-4, 2008. Pubmed reference: 19192154 . DOI: 10.1111/j.1939-1676.2008.0266.x . |
| 2008 |
Oyama,MA.,Reiken,S.,Lehnart,SE.,Chittur,SV.,Meurs,KM.,Stern,J.,Marks,AR.: :
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. J Vet Cardiol 10:1-10, 2008. Pubmed reference: 18515204 . DOI: 10.1016/j.jvc.2008.04.003 . |
| 2007 |
Meurs,KM.,Ederer,MM.,Stern,JA.: :
Desmosomal gene evaluation in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am J Vet Res 68:1338-41, 2007. Pubmed reference: 18052738 . DOI: 10.2460/ajvr.68.12.1338 . |
| 2006 |
Nelson,OL.,Lahmers,S.,Schneider,T.,Thompson,P.: :
The use of an implantable cardioverter defibrillator in a Boxer Dog to control clinical signs of arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 20:1232-7, 2006. Pubmed reference: 17063723 . |
| 2004 |
Basso,C.,Fox,PR.,Meurs,KM.,Towbin,JA.,Spier,AW.,Calabrese,F.,Maron,BJ.,Thiene,G.: :
Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease. Circulation 109:1180-5, 2004. Pubmed reference: 14993138 . DOI: 10.1161/01.CIR.0000118494.07530.65 . |
| 1999 |
Meurs,K.M.,Spier,A.W.,Miller,M.W.,Lehmkuhl,L.,Towbin,J.A.: :
Familial ventricular arrhythmias in boxers Journal of Veterinary Internal Medicine 13:437-439, 1999. Pubmed reference: 10499727 . |
| 1995 |
Bright,J.M.,Mcentee,M.: :
Isolated right ventricular cardiomyopathy in a dog Journal of the American Veterinary Medical Association 207:64-66, 1995. Pubmed reference: 7601695 . |
| 1994 |
Simpson,K.W.,Bonagura,J.D.,Eaton,K.A.: :
Right Ventricular Cardiomyopathy in a Dog Journal of Veterinary Internal Medicine 8:306-309, 1994. Pubmed reference: 7983631 . |
| 1991 |
Harpster,NK.: :
Boxer cardiomyopathy. A review of the long-term benefits of antiarrhythmic therapy. Vet Clin North Am Small Anim Pract 21:989-1004, 1991. Pubmed reference: 1949503 . |