The detail information of Cleft lip
Basic Information

Disease Ontology ID: DDTO:0000451

Disease Description: A condition where the two halves of the upper lip do not join together. Cleft palate and cleft lip are often seen together.

Inherit Mode: Cleft palate is believed to be an autosomal recessive trait in the Brittany spaniel.In the English and French bulldog, pointer, and shih tzu, the trait may be autosomal dominant with incomplete penetrance.

Disease Symptom: Affected pups are born with the condition. A minor defect will cause little or no problem, while a more severe defect will cause signs such as a chronic nasal discharge (that may include food), poor growth, aspiration pneumonia (from inhalation of food), or even death.

Disease Cause: -

Disease Diagnose: Your veterinarian will diagnose these conditions on physical examination.

Treat Method: Mild problems may not require any treatment, but more serious defects will require surgical repair to prevent complications such as aspiration pneumonia.

Breeder Advice: Affected animals should not be used for breeding, and it is prudent to avoid breeding their parents and siblings as well.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Cleft lip and palate - Autosomal Recessive - -
Cleft lip with or without cleft palate - Autosomal Recessive -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB46 Boston Terrier Friendly, bright, amusing, and adaptable. 38.1-43.2 cm 4.5-11.3 kg United States
CB54 Brittany Bright, upbeat, fun-loving at home; a tireless, enthusiastic worker afield 44.5-52.1 cm 13.6-18.1 kg France
CB58 English Bulldog Calm, courageous, and friendly; dignified but amusing. 35.6-38.1 cm 22.7 kg (male), 18.1 kg (female) United Kingdom (England)
CB78 Cocker Spaniel Happy, smart, gentle 36.8-39.4 cm (male), 34.3-36.8 cm (female) 11.3-13.6 kg (male), 9.1-11.3 kg (female)
CB83 Dachshund Friendly, Curious, Spunky 20.3-22.9 cm (standard), 12.7-15.2 cm (miniature) 7.3-14.5 kg (standard), 5 kg & under (miniature) Germany
CB98 English Toy Spaniel Affectionate, Alert, Merry 22.9-25.4 cm 3.6-6.4 kg England
CB106 French Bulldog Playful, smart, adaptable, and completely irresistible 27.9-33 cm under 12.7 kg United Kingdom (England), France
CB110 German Shepherd Dog Smart, confident, courageous, and steady; a true dog lover's dog 61-66 cm (male), 55.9-61 cm (female) 29.5-40.8 kg (male), 22.7-31.8 kg (female) Germany
CB147 Labrador Retriever Friendly and outgoing, Labs play well with others 57.2-62.2 cm (male), 54.6-59.7 cm (female) 29.5-36.3 kg (male), 24.9-31.8 kg (female) Canada, United Kingdom (England)
CB161 Miniature Schnauzer Friendly, smart, obedient 30.5-35.6 cm 5-9.1 kg Germany
CB178 Pekingese Affectionate, loyal, regal in manner 15.2-22.9 cm up to 6.4 kg China
CB185 English Pointer Even-tempered, alert, hardworking, and loyal; a peerless hunting partner 63.5-71.1 cm (male), 58.4-66 cm (female) 24.9-34 kg (male), 20.4-29.5 kg (female) United Kingdom (England)
CB218 Shih Tzu(Chrysanthemum Dog) Outgoing, affectionate, playful and charming 20.3-27.9 cm 4.1-7.3 kg China
CB265 American Pit Bull Terrier Strength, confidence, and zest for life,eager to please and brimming over with enthusiasm,excellent family companions 45.7-53.3 cm (male), 43.2 to 50.8 cm (female) 15.9-27.2 kg (male), 13.6-22.7 kg (female) United States
CB11 American Staffordshire Terrier Confident, Smart, Good-natured 18-19 inches (male), 17-18 inches (female) 55-70 pounds (male), 40-55 pounds (female) United States
CB25 Bearded Collie Bouncy, charismatic, friendly; smart, but also stubborn and independent 53.3-55.9 cm (male), 50.8-53.3 cm (female) 20.4-24.9 kg United Kingdom (Scotland)
CB35 Bichon Frise Playful, curious, and peppy 24.1-29.2 cm 5.4-8.2 kg Spain, Belgium
CB47 Bouvier des Flandres(Flanders Cattle Dog) Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders 62.2-69.9 cm (male), 59.7-67.3 cm (female) 31.8-49.9 kg Belgium
CB107 French Spaniel Friendly, outgoing personality, well balanced and patient,eager to please, can be trained easily France
CB111 German Short-Haired Pointer Friendly, smart, willing to please 58.4-63.5 cm (male), 53.3-58.4 cm (female) 24.9-31.8 kg (male), 20.4-27.2 kg (female) Germany
CB197 Hungarian Puli Loyal, smart, home-loving; strong-willed but trainable 43.2 cm (male), 40.6 cm (female) 11.3-15.9 kg Hungary
CB219 Kochi Ken(Shikoku) Cautious and brave with good judgment,loyal to its master. Japan
Associated Disease Variants from OMIA
Gene Differential Expression
References
2019 Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: :
Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019.
Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 .
2019 Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: :
Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019.
Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 .
2017 Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: :
Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017.
Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 .
2017 Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: :
Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017.
Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 .
2015 Wolf,Z.T.,Brand,H.A.,Shaffer,J.R.,Leslie,E.J.,Arzi,B.,Willet,C.E.,Cox,T.C.,McHenry,T.,Narayan,N.,Feingold,E.,Wang,X.,Sliskovic,S.,Karmi,N.,Safra,N.,Sanchez,C.,Deleyiannis,F.W.,Murray,J.C.,Wade,C.M.,Marazita,M.L.,Bannasch,D.L.: :
Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet 11:e1005059, 2015.
Pubmed reference: 25798845 . DOI: 10.1371/journal.pgen.1005059 .
2011 Moura,E.,Cirio,S.M.,Pimpão,C.T.: :
Non-Syndromic Cleft Lip and Palate in Boxer Dogs: Evidence of Monogenic Autosomal Recessive Inheritance. Cleft Palate Craniofac J :, 2011.
Pubmed reference: 21806339 . DOI: 10.1597/11-110 .
2009 Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: :
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009.
Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 .
2009 Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: :
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009.
Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 .
1972 Edmonds,L.,Stewart,R.W.,Selby,L.: :
Cleft lip and palate in dogs (Boxer breed): a preliminary report Carnivore Genetics Newsletter 9:204-209, 1972.
1971 Sherwood,B.F.,Vakilzadeh,J.,Lemay,J.C.: :
Observations on the pathology in a colony of cleft palate and cleft lip dogs. Cleft Palate J 8:56-60, 1971.
Pubmed reference: 5278761 .
1968 Jurkiewicz,M.J.,Bryant,D.L.: :
Cleft lip and palate in dogs: a progress report. Cleft Palate J 5:30-6, 1968.
Pubmed reference: 4383842 .
1965 Jurkiewicz,M.J.: :
A genetic study of cleft lip and palate in dogs. Surg Forum 16:472-3, 1965.
Pubmed reference: 5835234 .
1964 Jurkiewicz,M.J.: :
Cleft lip and palate in dogs. Surg Forum 15:457-8, 1964.
Pubmed reference: 14193444 .
1961 Calnan,J.: :
The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961.
Pubmed reference: 13875838 .
1961 Calnan,J.: :
The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961.
Pubmed reference: 13875838 .
1958 SETTY,L.R.: :
Cleft lip and palate in the dog. J Am Vet Med Assoc 133:480, 1958.
Pubmed reference: 13587379 .