BrainBase a curated knowledgebase for brain diseases

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    • 1. Overview

    Data Items Number
    Brain diseases
    Associations 6,690
    Categories 5
    Diseases 123
    Genes 5,262
    Publications 2,729
    Drugs
    Associations 16,591
    Drugs 2,118
    Brain diseases 8
    Targets 623
    Publications 336
    Glioma
    Omics signatures (Literature curation) 656
    Genes 363
    Publications 367
    Groups of featured genes 4
    Omics profiles 3
    Multi-omics datasets 21
    Specific genes
    Brain-specific genes 639
    Brain-region-specific genes 546
    Brain-specific proteins 215
    Cerebrospinal fluid detectable proteins 1,126
    Cell markers 328

    2. Brain diseases

    2.1 Disease-gene associations

    Alzheimer's DiseaseGliomaMultiple SclerosisAutism Spectrum DisorderAmyotrophic Lateral SclerosisParkinson's DiseaseEpilepsyNeuroblastomaStrokeSchizophreniaIntellectual DisabilityIntracranial AneurysmHuntington's DiseaseDown SyndromeMuscular DystrophyDystoniaCerebral PalsyCharcot-Marie-Tooth DiseaseRestless legs SyndromeBrain NeoplasmsAcute Ischemic StrokeNeurodegenerative DiseasePrader-Willi SyndromeDepression DisorderHydrocephalusCerebral IschemiaEncephalitisMeningiomaComaBipolar DisorderDysautonomiaCerebral MalariaAcute Cerebral InfarctionAnxiety DisorderTuberous SclerosisMotor Neurone DiseaseCerebral AneurysmAgenesis Corpus CallosumOthers

    2.2 Disease-gene publications

    PublicationsYear01002003004001990199319951997199920012003200520072009201120132015201720192021

    2.3 Top 10 genes by publications

    3. Drugs

    3.1 Drug-target interactions

    AcetaminophenAflatoxin B11,2-dimethylhydrazine4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2...AbrineAcrylamideAir Pollutants2,2',4,4'-tetrabromodiphenyl ether1-methyl-4-phenylpyridinium7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide1-methyl-3-isobutylxanthineAcetylcysteineAcetamide4,4'-diaminodiphenylmethane2,4,5,2',4',5'-hexachlorobiphenylAcrolein2,3,7,8-tetrachlorodibenzofuran1-Naphthylisothiocyanate3,4,5,3',4'-pentachlorobiphenyl2,6-dinitrotoluene2',3,3',4',5-pentachloro-4-hydroxybiphenyl2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one1,4-bis(2-(3,5-dichloropyridyloxy))benzene9,10-dimethyl-1,2-benzanthraceneAflatoxin B22-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

    3.2 Brain diseases with drug-target interactions

    Alzheimer's DiseaseParkinson's DiseaseGliomaGlioblastomaEpilepsyMedulloblastomaAutism Spectrum DisorderCerebral Palsy

    3.3 Top 10 targets by drugs

    TargetsDrugs NumberCXCL8HMOX1ESR1TP53BCL2BAXPTGS2IL6IL1BTNF0100200300400

    4. Glioma

    4.1 Top 10 signatures by associations

    AssociationsGenes010203040IDH1EGFRTP53MGMTPTENIDH2FGFR1PDGFRAEGFRvIIIH3-3A

    4.2 Hot signatures by publications

    IDH1EGFRTP53MGMTIDH2PTENFGFR1PDGFRAEGFRvIIIH3-3AMETNF1CDKN2AFOXM1TERTACVR1EZH2OLIG2RB1IDH1EGFRTP53MGMTIDH2PTENFGFR1PDGFRAEGFRvIIIH3-3AMETNF1CDKN2AFOXM1TERTACVR1EZH2OLIG2RB1

    4.3 Types of glioma associated genes

    4.4 Pathways of glioma associated genes

    4.5 Glioma predicted featured genes
    GroupsFeatured genesDCGsDMGsDEGsUDGs02,0004,0006,0008,00010,00012,000

    5. Specific genes

    5.1 Types of specific genes

    mRNAlncRNAOtherspseudogenemiRNACerebellumCerebellar HemisphereSpinal cord (cervical c-1)HypothalamusNucleus accumbens (basal ganglia)Substantia nigraFrontal Cortex (BA9)CortexHippocampusPutamen (basal ganglia)AmygdalaCaudate (basal ganglia)neuropilneuronal cellsPurkinje cellscells in granular layercells in molecular layerglial cellsneuronal projectionsendothelial cellssynapsesAstrocyteOligodendrocyteMacrophageNeuronMicroglial cellNeural stem cellEndothelial cellNeural progenitor cellOligodendrocyte precursor cellGlutamatergic neuronStem cellOligodendrocyte progenitor cellT helper2 cellPericyteM2 macrophageM1 macrophageB cellTypes of brain-specific genesRegions of brain-region-specific genesCell types of brain-specific proteinsCell types of cell markers for brain

    5.2 Brain-region-specific genes

    GenesBrain regions0306090120150180CerebellumCerebellar HemisphereSpinal cord (cervical c-1)HypothalamusNucleus accumbens (basal ganglia)Substantia nigraFrontal Cortex (BA9)CortexHippocampusPutamen (basal ganglia)