LncExpDB

Version 2.0

Expression Database of Human Long non-coding RNAs

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  • Contexts
  • Immunotherapy

    • LncExpDB identifies and characterizes immunotherapy-responsive genes across multiple cancer types, determines genes exhibiting high expression levels, and predicts lncRNA-mRNA interactions based on co-expression network analysis.

    • To better understand how featured lncRNA genes respond to immunotherapy, we investigated their correlations with tumor microenvironment (TME) signatures and cell types.
    • Click on the or dot to view detailed Tumor Microenvironment signature correlations, as well as the distribution of gene expression levels across responders and non-responders in a specific cancer type.

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    👇 Click on the dot to generate linear regression plot 👇

    Gene ID Gene Symbol Lymphoma Melanoma Non-Small Cell Lung Cancer Stomach Cancer Volcano Plot
    P.adj LogFC Up / Down P.adj LogFC Up / Down P.adj LogFC Up / Down P.adj LogFC Up / Down
    • Click on the "Expression Levels" Box plot to view the expression levels of the selected lncRNA across datasets, with its average highlighted alongside the overall gene expression average.
    • H, M, L, NE are used to represent lncRNA expression Levels. For specifics, please refer to Help > 2.5
    • Use the filter on the right to identify genes with cancer-specific expression levels: High (H), Medium (M), or Low (L).
    • Filter results by entering keywords in the Search box at the top right of the Table.
    Gene Symbol Gene ID Lymphoma Melanoma Non-Small Cell Lung Cancer Stomach Cancer Box plot
    Responder Non-Responder Responder Non-Responder Responder Non-Responder Responder Non-Responder

    Interaction

    • By clicking the tab of “Interactions”, you can select specific datasets of interest and browse the cis or trans interactions between lncRNAs and mRNAs.
    • Moreover, user can select a specific group of interaction by custom thresholds or search the related interactions by lncRNA/protein-coding id or symbol.
    Filter Criteria:
    LncRNA ID LncRNA Symbol LncRNA Location PCG ID PCG Symbol PCG Location R P value Distance