d-Amino acids in antimicrobial peptides: a potential approach to treat and combat antimicrobial resistance.

Shikha Kapil, Vipasha Sharma
Author Information
  1. Shikha Kapil: University Institute of Biotechnology, Chandigarh University, Gharuan Mohali, Punjab 140413, India.
  2. Vipasha Sharma: University Institute of Biotechnology, Chandigarh University, Gharuan Mohali, Punjab 140413, India.

Abstract

Antimicrobial resistance is one of the leading challenges in the human healthcare segment. Advances in antimicrobial resistance have triggered exploration of natural alternatives to stabilize its seriousness. Antimicrobial peptides are small, positively charged oligopeptides that are as potent as commercially available antibiotics against a wide spectrum of organisms, such as Gram-positive bacteria, Gram-negative bacteria, viruses, and fungal strains. In addition to their antibiotic capabilities, these peptides possess anticancer activity, activate the immune response, and regulate inflammation. Peptides have distinct modes of action and fall into various categories due to their amino acid composition. Although antimicrobial peptides specifically target the bacterial cytoplasmic membrane, they can also target the cell nucleus and protein synthesis. Owing to the increasing demand for novel treatments against the threat of antimicrobial resistance, naturally synthesized peptides are a beneficial development concept. Antimicrobial peptides are pervasive and can easily be modified using de-novo synthesis technology. Antimicrobial peptides can be isolated from natural resources such as humans, plants, bacteria, and fungi. This review gives a brief overview of antimicrobial peptides and their diastereomeric composition. Other current trends, the future scope of antimicrobial peptides, and the role of d-amino acids are also discussed, with a specific emphasis on the design and development of new drugs.

Keywords

MeSH Term

Amino Acids
Anti-Infective Agents
Cell Membrane
Cell Nucleus
Drug Development
Drug Resistance, Microbial
Pore Forming Cytotoxic Proteins
Protein Biosynthesis
Stereoisomerism

Chemicals

Amino Acids
Anti-Infective Agents
Pore Forming Cytotoxic Proteins

Word Cloud

Created with Highcharts 10.0.0peptidesantimicrobialresistanceAntimicrobialbacteriamembranecanacidsnaturalcompositiontargetbacterialcytoplasmicalsosynthesisdevelopmentd-aminooneleadingchallengeshumanhealthcaresegmentAdvancestriggeredexplorationalternativesstabilizeseriousnesssmallpositivelychargedoligopeptidespotentcommerciallyavailableantibioticswidespectrumorganismsGram-positiveGram-negativevirusesfungalstrainsadditionantibioticcapabilitiespossessanticanceractivityactivateimmuneresponseregulateinflammationPeptidesdistinctmodesactionfallvariouscategoriesdueaminoacidAlthoughspecificallycellnucleusproteinOwingincreasingdemandnoveltreatmentsthreatnaturallysynthesizedbeneficialconceptpervasiveeasilymodifiedusingde-novotechnologyisolatedresourceshumansplantsfungireviewgivesbriefoverviewdiastereomericcurrenttrendsfuturescoperolediscussedspecificemphasisdesignnewdrugsd-Aminopeptides:potentialapproachtreatcombatTrojanhorseacidesaminésdchevaldeTroieenantiomerscytoplasmiqueantimicrobiensrésistancebactérienneénantiomères

Similar Articles

Cited By (27)