Basic Information
Gene Structure
upstream:
Get Sequence
Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000147 | actin cortical patch assembly | BP |
| GO:0003674 | molecular_function | MF |
| GO:0005488 | binding | MF |
| GO:0005509 | calcium ion binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005856 | cytoskeleton | CC |
| GO:0005938 | cell cortex | CC |
| GO:0006810 | transport | BP |
| GO:0006886 | intracellular protein transport | BP |
| GO:0006897 | endocytosis | BP |
| GO:0006996 | organelle organization | BP |
| GO:0007010 | cytoskeleton organization | BP |
| GO:0008104 | protein localization | BP |
| GO:0008150 | biological_process | BP |
| GO:0009987 | cellular process | BP |
| GO:0015031 | protein transport | BP |
| GO:0015629 | actin cytoskeleton | CC |
| GO:0015833 | peptide transport | BP |
| GO:0016043 | cellular component organization | BP |
| GO:0016192 | vesicle-mediated transport | BP |
| GO:0022607 | cellular component assembly | BP |
| GO:0030029 | actin filament-based process | BP |
| GO:0030036 | actin cytoskeleton organization | BP |
| GO:0030479 | actin cortical patch | CC |
| GO:0030863 | cortical cytoskeleton | CC |
| GO:0030864 | cortical actin cytoskeleton | CC |
| GO:0030865 | cortical cytoskeleton organization | BP |
| GO:0030866 | cortical actin cytoskeleton organization | BP |
| GO:0033036 | macromolecule localization | BP |
| GO:0034613 | protein localization | BP |
| GO:0042886 | amide transport | BP |
| GO:0043167 | ion binding | MF |
| GO:0043169 | cation binding | MF |
| GO:0043226 | organelle | CC |
| GO:0043228 | non-membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043232 | intracellular non-membrane-bounded organelle | CC |
| GO:0044085 | cellular component biogenesis | BP |
| GO:0044396 | actin cortical patch organization | BP |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044430 | obsolete cytoskeletal part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044448 | obsolete cell cortex part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0045184 | establishment of protein localization | BP |
| GO:0046872 | metal ion binding | MF |
| GO:0046907 | intracellular transport | BP |
| GO:0051179 | localization | BP |
| GO:0051234 | establishment of localization | BP |
| GO:0051641 | cellular localization | BP |
| GO:0051649 | establishment of localization in cell | BP |
| GO:0061645 | endocytic patch | CC |
| GO:0070727 | cellular macromolecule localization | BP |
| GO:0071702 | organic substance transport | BP |
| GO:0071705 | nitrogen compound transport | BP |
| GO:0071840 | cellular component organization or biogenesis | BP |
| GO:0071944 | cell periphery | CC |
| GO:0098657 | import into cell | BP |
| GO:0099568 | cytoplasmic region | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map04144 | Endocytosis | Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. |