Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000339 | RNA cap binding | MF |
| GO:0000375 | RNA splicing, via transesterification reactions | BP |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | BP |
| GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation | BP |
| GO:0000398 | mRNA splicing, via spliceosome | BP |
| GO:0003674 | molecular_function | MF |
| GO:0003676 | nucleic acid binding | MF |
| GO:0003723 | RNA binding | MF |
| GO:0005488 | binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005845 | mRNA cap binding complex | CC |
| GO:0005846 | nuclear cap binding complex | CC |
| GO:0006139 | nucleobase-containing compound metabolic process | BP |
| GO:0006396 | RNA processing | BP |
| GO:0006397 | mRNA processing | BP |
| GO:0006725 | cellular aromatic compound metabolic process | BP |
| GO:0006807 | nitrogen compound metabolic process | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0008380 | RNA splicing | BP |
| GO:0009892 | negative regulation of metabolic process | BP |
| GO:0009987 | cellular process | BP |
| GO:0010033 | response to organic substance | BP |
| GO:0010467 | gene expression | BP |
| GO:0010468 | regulation of gene expression | BP |
| GO:0010605 | negative regulation of macromolecule metabolic process | BP |
| GO:0010608 | post-transcriptional regulation of gene expression | BP |
| GO:0010629 | negative regulation of gene expression | BP |
| GO:0014070 | response to organic cyclic compound | BP |
| GO:0016070 | RNA metabolic process | BP |
| GO:0016071 | mRNA metabolic process | BP |
| GO:0016441 | post-transcriptional gene silencing | BP |
| GO:0016458 | obsolete gene silencing | BP |
| GO:0019222 | regulation of metabolic process | BP |
| GO:0031047 | RNA-mediated gene silencing | BP |
| GO:0031050 | ncRNA processing | BP |
| GO:0031053 | primary miRNA processing | BP |
| GO:0032991 | protein-containing complex | CC |
| GO:0034470 | ncRNA processing | BP |
| GO:0034518 | RNA cap binding complex | CC |
| GO:0034641 | cellular nitrogen compound metabolic process | BP |
| GO:0034660 | ncRNA metabolic process | BP |
| GO:0035194 | RNA-mediated post-transcriptional gene silencing | BP |
| GO:0035195 | miRNA-mediated gene silencing | BP |
| GO:0035196 | miRNA processing | BP |
| GO:0040029 | epigenetic regulation of gene expression | BP |
| GO:0042221 | response to chemical | BP |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043331 | response to dsRNA | BP |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044238 | primary metabolic process | BP |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0046483 | heterocycle metabolic process | BP |
| GO:0048519 | negative regulation of biological process | BP |
| GO:0050789 | regulation of biological process | BP |
| GO:0050896 | response to stimulus | BP |
| GO:0051716 | cellular response to stimulus | BP |
| GO:0060255 | regulation of macromolecule metabolic process | BP |
| GO:0065007 | biological regulation | BP |
| GO:0070887 | cellular response to chemical stimulus | BP |
| GO:0070918 | regulatory ncRNA processing | BP |
| GO:0071310 | cellular response to organic substance | BP |
| GO:0071359 | cellular response to dsRNA | BP |
| GO:0071407 | cellular response to organic cyclic compound | BP |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0090304 | nucleic acid metabolic process | BP |
| GO:0097159 | organic cyclic compound binding | MF |
| GO:1901360 | organic cyclic compound metabolic process | BP |
| GO:1901363 | heterocyclic compound binding | MF |
| GO:1901698 | response to nitrogen compound | BP |
| GO:1901699 | cellular response to nitrogen compound | BP |
| KEGG Term | Name | Description |
|---|---|---|
| map03040 | Spliceosome | After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. |
| map03015 | mRNA surveillance pathway | The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. |
| map03013 | RNA transport | RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. |

