Basic Information
Gene Structure
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Domain
| Database | EntryID | E-Value | Start | end | InterPro ID | Description |
|---|
Regulation&Interaction
Annotation
Orthologous Group
| Orthologous ID | Species Number | All hits in PereRegDB | Hits of this species | Orthologous Detail |
|---|
Expression Profile
| DataSet | Number of Samples expressed(TPM>1) | Mean | Min | Max | Standard deviation(SD) | Coeffcient variation(CV) |
|---|
Pathway
| GO Term | Description | GO Category |
|---|---|---|
| GO:0000139 | Golgi membrane | CC |
| GO:0001881 | receptor recycling | BP |
| GO:0003674 | molecular_function | MF |
| GO:0005488 | binding | MF |
| GO:0005575 | cellular_component | CC |
| GO:0005622 | intracellular anatomical structure | CC |
| GO:0005623 | obsolete cell | CC |
| GO:0005737 | cytoplasm | CC |
| GO:0005768 | endosome | CC |
| GO:0005770 | late endosome | CC |
| GO:0005771 | multivesicular body | CC |
| GO:0005794 | Golgi apparatus | CC |
| GO:0005802 | trans-Golgi network | CC |
| GO:0006605 | protein targeting | BP |
| GO:0006623 | protein targeting to vacuole | BP |
| GO:0006810 | transport | BP |
| GO:0006886 | intracellular protein transport | BP |
| GO:0007034 | vacuolar transport | BP |
| GO:0008104 | protein localization | BP |
| GO:0008150 | biological_process | BP |
| GO:0008152 | metabolic process | BP |
| GO:0008270 | zinc ion binding | MF |
| GO:0009987 | cellular process | BP |
| GO:0010008 | endosome membrane | CC |
| GO:0012505 | endomembrane system | CC |
| GO:0015031 | protein transport | BP |
| GO:0015833 | peptide transport | BP |
| GO:0016020 | membrane | CC |
| GO:0016192 | vesicle-mediated transport | BP |
| GO:0016197 | endosomal transport | BP |
| GO:0016482 | cytosolic transport | BP |
| GO:0023051 | regulation of signaling | BP |
| GO:0030904 | retromer complex | CC |
| GO:0031090 | organelle membrane | CC |
| GO:0031410 | cytoplasmic vesicle | CC |
| GO:0031902 | late endosome membrane | CC |
| GO:0031982 | vesicle | CC |
| GO:0031984 | organelle subcompartment | CC |
| GO:0032588 | trans-Golgi network membrane | CC |
| GO:0032991 | protein-containing complex | CC |
| GO:0033036 | macromolecule localization | BP |
| GO:0033365 | protein localization to organelle | BP |
| GO:0034613 | protein localization | BP |
| GO:0042147 | retrograde transport, endosome to Golgi | BP |
| GO:0042886 | amide transport | BP |
| GO:0043112 | receptor metabolic process | BP |
| GO:0043167 | ion binding | MF |
| GO:0043169 | cation binding | MF |
| GO:0043170 | macromolecule metabolic process | BP |
| GO:0043226 | organelle | CC |
| GO:0043227 | membrane-bounded organelle | CC |
| GO:0043229 | intracellular organelle | CC |
| GO:0043231 | intracellular membrane-bounded organelle | CC |
| GO:0044237 | cellular metabolic process | BP |
| GO:0044260 | cellular macromolecule metabolic process | BP |
| GO:0044422 | obsolete organelle part | CC |
| GO:0044424 | obsolete intracellular part | CC |
| GO:0044425 | obsolete membrane part | CC |
| GO:0044431 | obsolete Golgi apparatus part | CC |
| GO:0044433 | obsolete cytoplasmic vesicle part | CC |
| GO:0044440 | obsolete endosomal part | CC |
| GO:0044444 | obsolete cytoplasmic part | CC |
| GO:0044446 | obsolete intracellular organelle part | CC |
| GO:0044464 | obsolete cell part | CC |
| GO:0045184 | establishment of protein localization | BP |
| GO:0046872 | metal ion binding | MF |
| GO:0046907 | intracellular transport | BP |
| GO:0046914 | transition metal ion binding | MF |
| GO:0050789 | regulation of biological process | BP |
| GO:0051179 | localization | BP |
| GO:0051234 | establishment of localization | BP |
| GO:0051641 | cellular localization | BP |
| GO:0051649 | establishment of localization in cell | BP |
| GO:0065007 | biological regulation | BP |
| GO:0070727 | cellular macromolecule localization | BP |
| GO:0071702 | organic substance transport | BP |
| GO:0071704 | organic substance metabolic process | BP |
| GO:0071705 | nitrogen compound transport | BP |
| GO:0072594 | establishment of protein localization to organelle | BP |
| GO:0072665 | protein localization to vacuole | BP |
| GO:0072666 | establishment of protein localization to vacuole | BP |
| GO:0097708 | intracellular vesicle | CC |
| GO:0098588 | bounding membrane of organelle | CC |
| GO:0098791 | Golgi apparatus subcompartment | CC |
| GO:0098796 | membrane protein complex | CC |
| GO:0098805 | membrane | CC |
| KEGG Term | Name | Description |
|---|---|---|
| map04144 | Endocytosis | Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. |

