Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
AALBA5B689931
Position
aalba5_s00133894:11890-14126 (-)
2236bp
Gene Type
gene
Gene Description (Protein Product)
DNA topoisomerase 2-binding protein
Organism
Abies alba
Also AS AT1G77320

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
AALBA5B719306 HELICc2
AALBA5B849739 Protein BREAST CANCER SUSCEPTIBILITY 2 homolog
AALBA5B980416 DNA repair and recombination protein
Regulatory gene
AALBA5B023305 dof zinc finger protein
AALBA5B087213 Cyclic dof factor
AALBA5B179847 dof zinc finger protein

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0000075 cell cycle checkpoint signaling BP
GO:0000076 DNA replication checkpoint signaling BP
GO:0000785 chromatin CC
GO:0001932 regulation of protein phosphorylation BP
GO:0001934 positive regulation of protein phosphorylation BP
GO:0003674 molecular_function MF
GO:0003682 chromatin binding MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005694 chromosome CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006260 DNA replication BP
GO:0006261 DNA-templated DNA replication BP
GO:0006270 DNA replication initiation BP
GO:0006275 regulation of DNA replication BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0007049 cell cycle BP
GO:0008104 protein localization BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009889 regulation of biosynthetic process BP
GO:0009893 positive regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010556 regulation of macromolecule biosynthetic process BP
GO:0010562 positive regulation of phosphorus metabolic process BP
GO:0010604 positive regulation of macromolecule metabolic process BP
GO:0016043 cellular component organization BP
GO:0019219 regulation of nucleobase-containing compound metabolic process BP
GO:0019220 regulation of phosphate metabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019899 enzyme binding MF
GO:0019900 kinase binding MF
GO:0022402 cell cycle process BP
GO:0022607 cellular component assembly BP
GO:0030174 regulation of DNA-templated DNA replication initiation BP
GO:0031323 regulation of cellular metabolic process BP
GO:0031325 positive regulation of cellular metabolic process BP
GO:0031326 regulation of cellular biosynthetic process BP
GO:0031399 regulation of protein modification process BP
GO:0031401 positive regulation of protein modification process BP
GO:0031570 DNA integrity checkpoint signaling BP
GO:0032268 regulation of protein metabolic process BP
GO:0032270 positive regulation of protein metabolic process BP
GO:0033036 macromolecule localization BP
GO:0033135 regulation of peptidyl-serine phosphorylation BP
GO:0033138 positive regulation of peptidyl-serine phosphorylation BP
GO:0033260 nuclear DNA replication BP
GO:0033365 protein localization to organelle BP
GO:0033554 cellular response to stress BP
GO:0033674 positive regulation of kinase activity BP
GO:0034502 protein localization to chromosome BP
GO:0034613 protein localization BP
GO:0034622 protein-containing complex assembly BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0035561 regulation of chromatin binding BP
GO:0035563 positive regulation of chromatin binding BP
GO:0042325 regulation of phosphorylation BP
GO:0042327 positive regulation of phosphorylation BP
GO:0043085 positive regulation of catalytic activity BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043549 regulation of kinase activity BP
GO:0043933 protein-containing complex organization BP
GO:0044085 cellular component biogenesis BP
GO:0044093 positive regulation of molecular function BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0044786 cell cycle DNA replication BP
GO:0045786 negative regulation of cell cycle BP
GO:0045859 regulation of protein kinase activity BP
GO:0045860 positive regulation of protein kinase activity BP
GO:0045937 positive regulation of phosphate metabolic process BP
GO:0046483 heterocycle metabolic process BP
GO:0048518 positive regulation of biological process BP
GO:0048519 negative regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048523 negative regulation of cellular process BP
GO:0050789 regulation of biological process BP
GO:0050790 regulation of catalytic activity BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051052 regulation of DNA metabolic process BP
GO:0051098 regulation of binding BP
GO:0051099 positive regulation of binding BP
GO:0051171 regulation of nitrogen compound metabolic process BP
GO:0051173 positive regulation of nitrogen compound metabolic process BP
GO:0051174 regulation of phosphorus metabolic process BP
GO:0051179 localization BP
GO:0051246 regulation of protein metabolic process BP
GO:0051247 positive regulation of protein metabolic process BP
GO:0051338 regulation of transferase activity BP
GO:0051347 positive regulation of transferase activity BP
GO:0051641 cellular localization BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065003 protein-containing complex assembly BP
GO:0065004 protein-DNA complex assembly BP
GO:0065007 biological regulation BP
GO:0065009 regulation of molecular function BP
GO:0070727 cellular macromolecule localization BP
GO:0071163 DNA replication preinitiation complex assembly BP
GO:0071165 GINS complex assembly BP
GO:0071168 protein localization to chromatin BP
GO:0071704 organic substance metabolic process BP
GO:0071824 protein-DNA complex subunit organization BP
GO:0071840 cellular component organization or biogenesis BP
GO:0080090 regulation of primary metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090329 regulation of DNA-templated DNA replication BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901576 organic substance biosynthetic process BP
GO:2000112 regulation of cellular macromolecule biosynthetic process BP
KEGG Term Name Description
map03440 Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.