Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
EVM0009620
View in Genome Browser
Position
GWHASIS00000030:222033-227830 (-)
5797bp
Gene Type
gene
Gene Description (Protein Product)
Cell cycle checkpoint control protein
Organism
Acer catalpifolium
Also AS AT3G05480

Gene Structure

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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
EVM0028943 Cell cycle checkpoint protein
EVM0027702 DNA repair endonuclease
EVM0033944 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication; cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base; leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway; by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA; and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA
Regulatory gene
EVM0001373 Transcriptional regulator
EVM0001785 transcription factor
EVM0002314 transcription factor

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway
GO Term Description GO Category
GO:0000075 cell cycle checkpoint signaling BP
GO:0000076 DNA replication checkpoint signaling BP
GO:0000077 DNA damage checkpoint signaling BP
GO:0000228 nuclear chromosome CC
GO:0000278 mitotic cell cycle BP
GO:0000793 condensed chromosome CC
GO:0000794 condensed nuclear chromosome CC
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0004518 nuclease activity MF
GO:0004527 exonuclease activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005654 nucleoplasm CC
GO:0005694 chromosome CC
GO:0005737 cytoplasm CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006281 DNA repair BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0007049 cell cycle BP
GO:0007093 mitotic cell cycle checkpoint signaling BP
GO:0007346 regulation of mitotic cell cycle BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008408 3'-5' exonuclease activity MF
GO:0009314 response to radiation BP
GO:0009628 response to abiotic stimulus BP
GO:0009966 regulation of signal transduction BP
GO:0009967 positive regulation of signal transduction BP
GO:0009987 cellular process BP
GO:0010212 response to ionizing radiation BP
GO:0010646 regulation of cell communication BP
GO:0010647 positive regulation of cell communication BP
GO:0010941 regulation of cell death BP
GO:0010942 positive regulation of cell death BP
GO:0016787 hydrolase activity MF
GO:0016788 hydrolase activity, acting on ester bonds MF
GO:0017124 SH3 domain binding MF
GO:0019899 enzyme binding MF
GO:0019900 kinase binding MF
GO:0019901 protein kinase binding MF
GO:0019904 protein domain specific binding MF
GO:0022402 cell cycle process BP
GO:0023051 regulation of signaling BP
GO:0023056 positive regulation of signaling BP
GO:0030896 checkpoint clamp complex CC
GO:0031570 DNA integrity checkpoint signaling BP
GO:0031573 mitotic intra-S DNA damage checkpoint signaling BP
GO:0031974 membrane-enclosed lumen CC
GO:0031981 nuclear lumen CC
GO:0032991 protein-containing complex CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0042826 histone deacetylase binding MF
GO:0042981 regulation of apoptotic process BP
GO:0043065 positive regulation of apoptotic process BP
GO:0043067 regulation of programmed cell death BP
GO:0043068 positive regulation of programmed cell death BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044427 obsolete chromosomal part CC
GO:0044428 obsolete nuclear part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044454 obsolete nuclear chromosome part CC
GO:0044464 obsolete cell part CC
GO:0044773 mitotic DNA damage checkpoint signaling BP
GO:0044774 mitotic DNA integrity checkpoint signaling BP
GO:0045786 negative regulation of cell cycle BP
GO:0045930 negative regulation of mitotic cell cycle BP
GO:0046483 heterocycle metabolic process BP
GO:0048518 positive regulation of biological process BP
GO:0048519 negative regulation of biological process BP
GO:0048522 positive regulation of cellular process BP
GO:0048523 negative regulation of cellular process BP
GO:0048583 regulation of response to stimulus BP
GO:0048584 positive regulation of response to stimulus BP
GO:0050789 regulation of biological process BP
GO:0050794 regulation of cellular process BP
GO:0050896 response to stimulus BP
GO:0051716 cellular response to stimulus BP
GO:0051726 regulation of cell cycle BP
GO:0065007 biological regulation BP
GO:0070013 intracellular organelle lumen CC
GO:0071214 cellular response to abiotic stimulus BP
GO:0071478 cellular response to radiation BP
GO:0071479 cellular response to ionizing radiation BP
GO:0071704 organic substance metabolic process BP
GO:0080134 regulation of response to stress BP
GO:0080135 regulation of cellular response to stress BP
GO:0090304 nucleic acid metabolic process BP
GO:0090305 nucleic acid phosphodiester bond hydrolysis BP
GO:0104004 cellular response to environmental stimulus BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage BP
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage BP
GO:1902531 regulation of intracellular signal transduction BP
GO:1902533 positive regulation of intracellular signal transduction BP
GO:1903047 mitotic cell cycle process BP
GO:2001020 regulation of response to DNA damage stimulus BP
GO:2001022 positive regulation of response to DNA damage stimulus BP
GO:2001233 regulation of apoptotic signaling pathway BP
GO:2001235 positive regulation of apoptotic signaling pathway BP
GO:2001242 regulation of intrinsic apoptotic signaling pathway BP
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway BP