PPGR - Gene Detail

Basic Information

Gene Structure

Domain

Regulation&
Interaction

Annotation

Orthologus Group

Pathway

Basic Information

Gene ID	EVM0013841 View in Genome Browser
Position	GWHASIS00000033:18409372-18414188 (+) 4816bp
Gene Type	gene
Gene Description (Protein Product)	Protein BREAST CANCER SUSCEPTIBILITY
Organism	Acer catalpifolium
Also AS	AT1G04020

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Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)	EVM0014989 Protein BREAST CANCER SUSCEPTIBILITY 1 homolog EVM0028144 Anaphase-promoting complex subunit EVM0018405 Anaphase-promoting complex subunit
Regulatory gene	EVM0001315 transcription factor that promotes early floral meristem identity in synergy with APETALA1; FRUITFULL and LEAFY. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1 EVM0003629 MADS-box protein EVM0005245 MADS-box protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0000151	ubiquitin ligase complex	CC
GO:0000152	nuclear ubiquitin ligase complex	CC
GO:0000724	double-strand break repair via homologous recombination	BP
GO:0000725	recombinational repair	BP
GO:0003674	molecular_function	MF
GO:0003676	nucleic acid binding	MF
GO:0003677	DNA binding	MF
GO:0003824	catalytic activity	MF
GO:0004842	ubiquitin-protein transferase activity	MF
GO:0005488	binding	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005634	nucleus	CC
GO:0005886	plasma membrane	CC
GO:0006139	nucleobase-containing compound metabolic process	BP
GO:0006259	DNA metabolic process	BP
GO:0006281	DNA repair	BP
GO:0006302	double-strand break repair	BP
GO:0006310	DNA recombination	BP
GO:0006325	chromatin organization	BP
GO:0006355	regulation of DNA-templated transcription	BP
GO:0006357	regulation of transcription by RNA polymerase II	BP
GO:0006464	protein modification process	BP
GO:0006479	protein methylation	BP
GO:0006725	cellular aromatic compound metabolic process	BP
GO:0006807	nitrogen compound metabolic process	BP
GO:0006950	response to stress	BP
GO:0006974	cellular response to DNA damage stimulus	BP
GO:0006996	organelle organization	BP
GO:0007275	multicellular organism development	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0008213	protein alkylation	BP
GO:0009314	response to radiation	BP
GO:0009628	response to abiotic stimulus	BP
GO:0009653	anatomical structure morphogenesis	BP
GO:0009888	tissue development	BP
GO:0009889	regulation of biosynthetic process	BP
GO:0009890	negative regulation of biosynthetic process	BP
GO:0009891	positive regulation of biosynthetic process	BP
GO:0009892	negative regulation of metabolic process	BP
GO:0009893	positive regulation of metabolic process	BP
GO:0009934	regulation of meristem structural organization	BP
GO:0009987	cellular process	BP
GO:0010015	root morphogenesis	BP
GO:0010073	meristem maintenance	BP
GO:0010074	maintenance of meristem identity	BP
GO:0010078	maintenance of root meristem identity	BP
GO:0010212	response to ionizing radiation	BP
GO:0010332	response to gamma radiation	BP
GO:0010468	regulation of gene expression	BP
GO:0010492	maintenance of shoot apical meristem identity	BP
GO:0010556	regulation of macromolecule biosynthetic process	BP
GO:0010557	positive regulation of macromolecule biosynthetic process	BP
GO:0010558	negative regulation of macromolecule biosynthetic process	BP
GO:0010564	regulation of cell cycle process	BP
GO:0010565	regulation of cellular ketone metabolic process	BP
GO:0010604	positive regulation of macromolecule metabolic process	BP
GO:0010605	negative regulation of macromolecule metabolic process	BP
GO:0010628	positive regulation of gene expression	BP
GO:0010629	negative regulation of gene expression	BP
GO:0010638	positive regulation of organelle organization	BP
GO:0010639	negative regulation of organelle organization	BP
GO:0016020	membrane	CC
GO:0016043	cellular component organization	BP
GO:0016567	protein ubiquitination	BP
GO:0016569	obsolete covalent chromatin modification	BP
GO:0016570	histone modification	BP
GO:0016571	histone methylation	BP
GO:0016740	transferase activity	MF
GO:0018022	peptidyl-lysine methylation	BP
GO:0018023	peptidyl-lysine trimethylation	BP
GO:0018193	peptidyl-amino acid modification	BP
GO:0018205	peptidyl-lysine modification	BP
GO:0019216	regulation of lipid metabolic process	BP
GO:0019217	regulation of fatty acid metabolic process	BP
GO:0019219	regulation of nucleobase-containing compound metabolic process	BP
GO:0019222	regulation of metabolic process	BP
GO:0019538	protein metabolic process	BP
GO:0019787	ubiquitin-like protein transferase activity	MF
GO:0019827	stem cell population maintenance	BP
GO:0022603	regulation of anatomical structure morphogenesis	BP
GO:0022607	cellular component assembly	BP
GO:0022622	root system development	BP
GO:0031056	regulation of histone modification	BP
GO:0031057	negative regulation of histone modification	BP
GO:0031058	positive regulation of histone modification	BP
GO:0031323	regulation of cellular metabolic process	BP
GO:0031324	negative regulation of cellular metabolic process	BP
GO:0031325	positive regulation of cellular metabolic process	BP
GO:0031326	regulation of cellular biosynthetic process	BP
GO:0031327	negative regulation of cellular biosynthetic process	BP
GO:0031328	positive regulation of cellular biosynthetic process	BP
GO:0031399	regulation of protein modification process	BP
GO:0031400	negative regulation of protein modification process	BP
GO:0031401	positive regulation of protein modification process	BP
GO:0031436	BRCA1-BARD1 complex	CC
GO:0032259	methylation	BP
GO:0032268	regulation of protein metabolic process	BP
GO:0032269	negative regulation of protein metabolic process	BP
GO:0032270	positive regulation of protein metabolic process	BP
GO:0032446	protein modification by small protein conjugation	BP
GO:0032501	multicellular organismal process	BP
GO:0032502	developmental process	BP
GO:0032991	protein-containing complex	CC
GO:0033043	regulation of organelle organization	BP
GO:0033044	regulation of chromosome organization	BP
GO:0033554	cellular response to stress	BP
GO:0034622	protein-containing complex assembly	BP
GO:0034641	cellular nitrogen compound metabolic process	BP
GO:0034968	histone lysine methylation	BP
GO:0035065	regulation of histone acetylation	BP
GO:0035066	positive regulation of histone acetylation	BP
GO:0035067	negative regulation of histone acetylation	BP
GO:0036211	protein modification process	BP
GO:0042127	regulation of cell population proliferation	BP
GO:0042304	regulation of fatty acid biosynthetic process	BP
GO:0043170	macromolecule metabolic process	BP
GO:0043226	organelle	CC
GO:0043227	membrane-bounded organelle	CC
GO:0043229	intracellular organelle	CC
GO:0043231	intracellular membrane-bounded organelle	CC
GO:0043412	macromolecule modification	BP
GO:0043414	macromolecule methylation	BP
GO:0043933	protein-containing complex organization	BP
GO:0044085	cellular component biogenesis	BP
GO:0044237	cellular metabolic process	BP
GO:0044238	primary metabolic process	BP
GO:0044260	cellular macromolecule metabolic process	BP
GO:0044267	protein metabolic process	BP
GO:0044422	obsolete organelle part	CC
GO:0044424	obsolete intracellular part	CC
GO:0044428	obsolete nuclear part	CC
GO:0044446	obsolete intracellular organelle part	CC
GO:0044464	obsolete cell part	CC
GO:0045717	negative regulation of fatty acid biosynthetic process	BP
GO:0045787	positive regulation of cell cycle	BP
GO:0045833	negative regulation of lipid metabolic process	BP
GO:0045892	negative regulation of DNA-templated transcription	BP
GO:0045893	positive regulation of DNA-templated transcription	BP
GO:0045922	negative regulation of fatty acid metabolic process	BP
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	BP
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	BP
GO:0045944	positive regulation of transcription by RNA polymerase II	BP
GO:0046483	heterocycle metabolic process	BP
GO:0046890	regulation of lipid biosynthetic process	BP
GO:0048364	root development	BP
GO:0048366	leaf development	BP
GO:0048367	shoot system development	BP
GO:0048507	meristem development	BP
GO:0048509	regulation of meristem development	BP
GO:0048518	positive regulation of biological process	BP
GO:0048519	negative regulation of biological process	BP
GO:0048522	positive regulation of cellular process	BP
GO:0048523	negative regulation of cellular process	BP
GO:0048731	system development	BP
GO:0048827	phyllome development	BP
GO:0048856	anatomical structure development	BP
GO:0050789	regulation of biological process	BP
GO:0050793	regulation of developmental process	BP
GO:0050794	regulation of cellular process	BP
GO:0050896	response to stimulus	BP
GO:0051055	negative regulation of lipid biosynthetic process	BP
GO:0051128	regulation of cellular component organization	BP
GO:0051129	negative regulation of cellular component organization	BP
GO:0051130	positive regulation of cellular component organization	BP
GO:0051171	regulation of nitrogen compound metabolic process	BP
GO:0051172	negative regulation of nitrogen compound metabolic process	BP
GO:0051173	positive regulation of nitrogen compound metabolic process	BP
GO:0051246	regulation of protein metabolic process	BP
GO:0051247	positive regulation of protein metabolic process	BP
GO:0051248	negative regulation of protein metabolic process	BP
GO:0051252	regulation of RNA metabolic process	BP
GO:0051253	negative regulation of RNA metabolic process	BP
GO:0051254	positive regulation of RNA metabolic process	BP
GO:0051276	chromosome organization	BP
GO:0051568	histone H3-K4 methylation	BP
GO:0051716	cellular response to stimulus	BP
GO:0051726	regulation of cell cycle	BP
GO:0060255	regulation of macromolecule metabolic process	BP
GO:0062012	regulation of small molecule metabolic process	BP
GO:0062014	negative regulation of small molecule metabolic process	BP
GO:0065003	protein-containing complex assembly	BP
GO:0065004	protein-DNA complex assembly	BP
GO:0065007	biological regulation	BP
GO:0070531	BRCA1-A complex	CC
GO:0070647	protein modification by small protein conjugation or removal	BP
GO:0071156	regulation of cell cycle	BP
GO:0071158	regulation of cell cycle	BP
GO:0071214	cellular response to abiotic stimulus	BP
GO:0071478	cellular response to radiation	BP
GO:0071479	cellular response to ionizing radiation	BP
GO:0071480	cellular response to gamma radiation	BP
GO:0071704	organic substance metabolic process	BP
GO:0071824	protein-DNA complex subunit organization	BP
GO:0071840	cellular component organization or biogenesis	BP
GO:0071944	cell periphery	CC
GO:0080090	regulation of primary metabolic process	BP
GO:0080182	histone H3-K4 trimethylation	BP
GO:0090068	positive regulation of cell cycle process	BP
GO:0090304	nucleic acid metabolic process	BP
GO:0097159	organic cyclic compound binding	MF
GO:0098727	maintenance of cell number	BP
GO:0099402	plant organ development	BP
GO:0104004	cellular response to environmental stimulus	BP
GO:0140096	catalytic activity, acting on a protein	MF
GO:1901360	organic cyclic compound metabolic process	BP
GO:1901363	heterocyclic compound binding	MF
GO:1901564	organonitrogen compound metabolic process	BP
GO:1901983	regulation of protein acetylation	BP
GO:1901984	negative regulation of protein acetylation	BP
GO:1901985	positive regulation of protein acetylation	BP
GO:1902275	regulation of chromatin organization	BP
GO:1902494	catalytic complex	CC
GO:1902679	negative regulation of RNA biosynthetic process	BP
GO:1902680	positive regulation of RNA biosynthetic process	BP
GO:1903506	regulation of nucleic acid-templated transcription	BP
GO:1903507	negative regulation of nucleic acid-templated transcription	BP
GO:1903508	positive regulation of nucleic acid-templated transcription	BP
GO:1905268	negative regulation of chromatin organization	BP
GO:1905269	positive regulation of chromatin organization	BP
GO:1905392	plant organ morphogenesis	BP
GO:1990234	transferase complex	CC
GO:2000112	regulation of cellular macromolecule biosynthetic process	BP
GO:2000113	negative regulation of cellular macromolecule biosynthetic process	BP
GO:2000756	regulation of peptidyl-lysine acetylation	BP
GO:2000757	negative regulation of peptidyl-lysine acetylation	BP
GO:2000758	positive regulation of peptidyl-lysine acetylation	BP
GO:2001141	regulation of RNA biosynthetic process	BP
GO:2001251	negative regulation of chromosome organization	BP
GO:2001252	positive regulation of chromosome organization	BP

KEGG Term	Name	Description
map03440	Homologous recombination	Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.