Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Pathway
Basic Information
Gene ID
EVM0031220
View in Genome Browser
Position
GWHASIS00001318:29848161-29853823 (-)
5662bp
Gene Type
gene
Gene Description (Protein Product)
DNA-(Apurinic or apyrimidinic site) lyase
Organism
Acer catalpifolium
Also AS AT4G36050

Gene Structure

upstream:
Get Sequence

Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
EVM0031886 Participates in DNA repair and in chromosomal DNA replication
EVM0031443 dna polymerase delta small
EVM0033944 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication; cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base; leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway; by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA; and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA
Regulatory gene
EVM0000098 DnaJ homolog; subfamily C; member
EVM0001315 transcription factor that promotes early floral meristem identity in synergy with APETALA1; FRUITFULL and LEAFY. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1
EVM0001481 Transcription factor

Load All Networks

Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
Go Pathway KEGG Pathway
GO Term Description GO Category
GO:0001650 fibrillar center CC
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity MF
GO:0004518 nuclease activity MF
GO:0004527 exonuclease activity MF
GO:0004529 DNA exonuclease activity MF
GO:0004536 deoxyribonuclease activity MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005634 nucleus CC
GO:0005730 nucleolus CC
GO:0005737 cytoplasm CC
GO:0005739 mitochondrion CC
GO:0005740 mitochondrial envelope CC
GO:0005743 mitochondrial inner membrane CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006259 DNA metabolic process BP
GO:0006281 DNA repair BP
GO:0006284 base-excision repair BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006950 response to stress BP
GO:0006974 cellular response to DNA damage stimulus BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008296 3'-5'-DNA exonuclease activity MF
GO:0008309 double-stranded DNA exodeoxyribonuclease activity MF
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity MF
GO:0008408 3'-5' exonuclease activity MF
GO:0009987 cellular process BP
GO:0016020 membrane CC
GO:0016787 hydrolase activity MF
GO:0016788 hydrolase activity, acting on ester bonds MF
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters MF
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters MF
GO:0019866 organelle inner membrane CC
GO:0031090 organelle membrane CC
GO:0031966 mitochondrial membrane CC
GO:0031967 organelle envelope CC
GO:0031974 membrane-enclosed lumen CC
GO:0031975 envelope CC
GO:0031981 nuclear lumen CC
GO:0033554 cellular response to stress BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043228 non-membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043232 intracellular non-membrane-bounded organelle CC
GO:0043233 organelle lumen CC
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044428 obsolete nuclear part CC
GO:0044429 obsolete mitochondrial part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044452 obsolete nucleolar part CC
GO:0044464 obsolete cell part CC
GO:0046483 heterocycle metabolic process BP
GO:0050896 response to stimulus BP
GO:0051716 cellular response to stimulus BP
GO:0070013 intracellular organelle lumen CC
GO:0071704 organic substance metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0090305 nucleic acid phosphodiester bond hydrolysis BP
GO:0140097 catalytic activity, acting on DNA MF
GO:1901360 organic cyclic compound metabolic process BP
KEGG Term Name Description
map03410 Base excision repair Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.