Basic Information
Gene ID
Position
GWHASIS00000029:6738254-6746655 (+)
8401bp
Gene Type
gene
Gene Description (Protein Product)
May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA; a mechanism to release non-functional ribosomes and degrade damaged mRNAs
Organism
Also AS AT4G27650

Gene Structure

upstream:

Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
EVM0034705 BAHD acyltransferase
EVM0033383 Poly(A) RNA polymerase
EVM0034147 Nuclear transcription factor Y subunit
Regulatory gene
EVM0001315 transcription factor that promotes early floral meristem identity in synergy with APETALA1; FRUITFULL and LEAFY. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1
EVM0003629 MADS-box protein
EVM0005245 MADS-box protein

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail


Pathway
GO Term Description GO Category
GO:0000956 nuclear-transcribed mRNA catabolic process BP
GO:0003674 molecular_function MF
GO:0005488 binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005737 cytoplasm CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006401 RNA catabolic process BP
GO:0006402 mRNA catabolic process BP
GO:0006412 translation BP
GO:0006518 peptide metabolic process BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0006996 organelle organization BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0009056 catabolic process BP
GO:0009057 macromolecule catabolic process BP
GO:0009058 biosynthetic process BP
GO:0009059 macromolecule biosynthetic process BP
GO:0009892 negative regulation of metabolic process BP
GO:0009987 cellular process BP
GO:0010467 gene expression BP
GO:0010468 regulation of gene expression BP
GO:0010605 negative regulation of macromolecule metabolic process BP
GO:0010629 negative regulation of gene expression BP
GO:0016043 cellular component organization BP
GO:0016070 RNA metabolic process BP
GO:0016071 mRNA metabolic process BP
GO:0016072 rRNA metabolic process BP
GO:0016075 rRNA catabolic process BP
GO:0019222 regulation of metabolic process BP
GO:0019439 aromatic compound catabolic process BP
GO:0019538 protein metabolic process BP
GO:0022411 cellular component disassembly BP
GO:0032790 ribosome disassembly BP
GO:0032984 protein-containing complex disassembly BP
GO:0032988 ribonucleoprotein complex disassembly BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034645 cellular macromolecule biosynthetic process BP
GO:0034655 nucleobase-containing compound catabolic process BP
GO:0034660 ncRNA metabolic process BP
GO:0034661 ncRNA catabolic process BP
GO:0043021 ribonucleoprotein complex binding MF
GO:0043022 ribosome binding MF
GO:0043043 peptide biosynthetic process BP
GO:0043170 macromolecule metabolic process BP
GO:0043603 amide metabolic process BP
GO:0043604 amide biosynthetic process BP
GO:0043933 protein-containing complex organization BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044248 cellular catabolic process BP
GO:0044249 cellular biosynthetic process BP
GO:0044260 cellular macromolecule metabolic process BP
GO:0044265 cellular macromolecule catabolic process BP
GO:0044267 protein metabolic process BP
GO:0044270 cellular nitrogen compound catabolic process BP
GO:0044271 cellular nitrogen compound biosynthetic process BP
GO:0044424 obsolete intracellular part CC
GO:0044464 obsolete cell part CC
GO:0044877 protein-containing complex binding MF
GO:0046483 heterocycle metabolic process BP
GO:0046700 heterocycle catabolic process BP
GO:0048519 negative regulation of biological process BP
GO:0050789 regulation of biological process BP
GO:0060255 regulation of macromolecule metabolic process BP
GO:0065007 biological regulation BP
GO:0070651 nonfunctional rRNA decay BP
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay BP
GO:0071704 organic substance metabolic process BP
GO:0071826 ribonucleoprotein complex subunit organization BP
GO:0071840 cellular component organization or biogenesis BP
GO:0090304 nucleic acid metabolic process BP
GO:1901360 organic cyclic compound metabolic process BP
GO:1901361 organic cyclic compound catabolic process BP
GO:1901564 organonitrogen compound metabolic process BP
GO:1901566 organonitrogen compound biosynthetic process BP
GO:1901575 organic substance catabolic process BP
GO:1901576 organic substance biosynthetic process BP
GO:1903008 organelle disassembly BP
KEGG Term Name Description
map03015 mRNA surveillance pathway The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.