Basic Information
Gene Structure
Domain
Regulation&
Interaction
Annotation
Orthologus Group
Expresssion
Pathway
Basic Information
Gene ID
gene-Apse010G0101800
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Position
GWHBECT00000010:12478010-12491184 (+)
13174bp
Gene Type
gene
Gene Description (Protein Product)
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp; -Asn; -His and -Tyr); resulting in the hypermodified nucleoside queuosine (7-(((4;5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA; forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine; allowing a nucleophilic attack on the C1' of the ribose to form the product
Organism
Acer pseudosieboldianum
Also AS

Gene Structure

upstream:
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Domain
Database EntryID E-Value Start end InterPro ID Description

Regulation&Interaction
Protein-protein interaction (PPI)
gene-Apse012G0042900 Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp; -Asn; - His and -Tyr); resulting in the hypermodified nucleoside queuosine (7-(((4;5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7- deazaguanosine)
gene-Apse013G0060500 mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex; which is involved in protein synthesis of a specialized repertoire of mRNAs and; together with other initiation factors; stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex; eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs
gene-Apse011G0139900 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex; which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation

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Annotation

Orthologous Group
Orthologous ID Species Number All hits in PereRegDB Hits of this species Orthologous Detail

Expression Profile
DataSet Number of Samples expressed(TPM>1) Mean Min Max Standard deviation(SD) Coeffcient variation(CV)


Pathway
Go Pathway
GO Term Description GO Category
GO:0003674 molecular_function MF
GO:0003824 catalytic activity MF
GO:0005488 binding MF
GO:0005515 protein binding MF
GO:0005575 cellular_component CC
GO:0005622 intracellular anatomical structure CC
GO:0005623 obsolete cell CC
GO:0005737 cytoplasm CC
GO:0005739 mitochondrion CC
GO:0005740 mitochondrial envelope CC
GO:0005741 mitochondrial outer membrane CC
GO:0006139 nucleobase-containing compound metabolic process BP
GO:0006396 RNA processing BP
GO:0006399 tRNA metabolic process BP
GO:0006400 tRNA modification BP
GO:0006725 cellular aromatic compound metabolic process BP
GO:0006807 nitrogen compound metabolic process BP
GO:0008033 tRNA processing BP
GO:0008150 biological_process BP
GO:0008152 metabolic process BP
GO:0008479 queuine tRNA-ribosyltransferase activity MF
GO:0009451 RNA modification BP
GO:0009987 cellular process BP
GO:0010467 gene expression BP
GO:0016020 membrane CC
GO:0016070 RNA metabolic process BP
GO:0016740 transferase activity MF
GO:0016757 glycosyltransferase activity MF
GO:0016763 pentosyltransferase activity MF
GO:0019867 outer membrane CC
GO:0031090 organelle membrane CC
GO:0031966 mitochondrial membrane CC
GO:0031967 organelle envelope CC
GO:0031968 organelle outer membrane CC
GO:0031975 envelope CC
GO:0032991 protein-containing complex CC
GO:0034470 ncRNA processing BP
GO:0034641 cellular nitrogen compound metabolic process BP
GO:0034660 ncRNA metabolic process BP
GO:0042802 identical protein binding MF
GO:0042803 protein homodimerization activity MF
GO:0043170 macromolecule metabolic process BP
GO:0043226 organelle CC
GO:0043227 membrane-bounded organelle CC
GO:0043229 intracellular organelle CC
GO:0043231 intracellular membrane-bounded organelle CC
GO:0043412 macromolecule modification BP
GO:0044237 cellular metabolic process BP
GO:0044238 primary metabolic process BP
GO:0044422 obsolete organelle part CC
GO:0044424 obsolete intracellular part CC
GO:0044429 obsolete mitochondrial part CC
GO:0044444 obsolete cytoplasmic part CC
GO:0044446 obsolete intracellular organelle part CC
GO:0044464 obsolete cell part CC
GO:0046483 heterocycle metabolic process BP
GO:0046982 protein heterodimerization activity MF
GO:0046983 protein dimerization activity MF
GO:0071704 organic substance metabolic process BP
GO:0090304 nucleic acid metabolic process BP
GO:0098588 bounding membrane of organelle CC
GO:0098805 membrane CC
GO:0101030 tRNA-guanine transglycosylation BP
GO:0140098 catalytic activity, acting on RNA MF
GO:0140101 catalytic activity, acting on a tRNA MF
GO:1901360 organic cyclic compound metabolic process BP