PPGR - Gene Detail

Basic Information

Gene ID	AmTr_scaff00147.45.v1.0.g View in Genome Browser
Position	AmTr_scaff00147:990252-1020637 (+) 30385bp
Gene Type	gene
Gene Description (Protein Product)	Methylenetetrahydrofolate reductase
Organism	Amborella trichopoda
Also AS	AT2G44160AMTR_s00147p00086270

upstream:

Domain

Database	EntryID	E-Value	Start	end	InterPro ID	Description

Regulation&Interaction

Protein-protein interaction (PPI)

AmTr_scaff00154.28.v1.0.g Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses

AmTr_scaff00175.20.v1.0.g Chorismate synthase

AmTr_scaff00183.5.v1.0.g Bifunctional purine biosynthesis protein

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Annotation

Orthologous Group

Orthologous ID	Species Number	All hits in PereRegDB	Hits of this species	Orthologous Detail

Pathway

GO Term	Description	GO Category
GO:0003674	molecular_function	MF
GO:0003824	catalytic activity	MF
GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	MF
GO:0005575	cellular_component	CC
GO:0005622	intracellular anatomical structure	CC
GO:0005623	obsolete cell	CC
GO:0005737	cytoplasm	CC
GO:0005829	cytosol	CC
GO:0006730	one-carbon metabolic process	BP
GO:0008150	biological_process	BP
GO:0008152	metabolic process	BP
GO:0009987	cellular process	BP
GO:0016491	oxidoreductase activity	MF
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	MF
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	MF
GO:0044237	cellular metabolic process	BP
GO:0044281	small molecule metabolic process	BP
GO:0044424	obsolete intracellular part	CC
GO:0044444	obsolete cytoplasmic part	CC
GO:0044464	obsolete cell part	CC
GO:0055114	obsolete oxidation-reduction process	BP

KEGG Term	Name	Description
map03440	Homologous recombination	Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
map01100	Metabolic pathways	-
map00670	One carbon pool by folate	-